Conserved Protein Domain Family
AAR2

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pfam05282: AAR2 
AAR2 protein
This family consists of several eukaryotic AAR2-like proteins. The yeast protein AAR2 is involved in splicing pre-mRNA of the a1 cistron and other genes that are important for cell growth.
Statistics
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PSSM-Id: 461609
Aligned: 96 rows
Threshold Bit Score: 191.351
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002948987  22 QG-GALLVLGLPEGSYFGIDHMAFR-CGPR-FRGVKMLPPGPHFVCYSVPGSeq--------rGGGMSPVTGFFFNvkaa 90 
XP_001730485  11 HY-AFLLLQNLPRASYVSIDQHAYR-TDTL-FEGFKLVPPGIHCLTWQSAGYaddr----qdaLATEGIRSALFLY---- 79 
GAC72603       8 DG-AVLLLNGLPARTQLVLDAHPQAyVTNDqFAGIKSLAPGWHCISWSLASEagnea-naggpSVEGSIRNVALRY---- 81 
CCF54578       2 AKnGMLLLNGLPTGSQFTIDSHTEAyLTNEqFAGIKGLPAGWHCISWSIASTqssfq--agavGVEGSVRNVLLRW---- 75 
XP_012190670   6 AS-AKLLLQGLPPRTQVSLDAHPEVyLTNEhFAGIKSLAPGWHCISWSIASSelssnegsqavPATSSIRNVLLKW---- 80 
KIS71263       6 GS-AQLLLNGLPPRTQITVDAHSETyVINErFSGIKSLPTGWHCISWSIPSSdsstdqcasarPSEVSLRNVLLRW---- 80 
EST06231       3 SAtATLLLKGLPGRTQLALDAQQDAyLNNEqFTGIKNLPAGWHCVSWSIATTssdd----tpgPSTGAVRNLLLRY---- 74 
Q5KPA5        15 AG-GFLIITDLPEGSEFGIDGTFHT-VRK--FSGIKFLPPGFHFIAWSPPPSstt------agPSVIPIRQAFVRN---- 80  Cryptococcus ne...
XP_012740529  80 EG-DVVIIAGVPPGSFIGYDTVGLNiEKNHhFGGIRELPPGPHFIYGGS--------------MSEISTRNGFWIIsnq- 143
EDN90691     171 DG-DVIIVGSLPPGSMFGYDTKAYTiKTEGtLEGVKNIPPGAHFFWGGS--------------ANG-SSRTGFWFMtmk- 233
XP_002948987  91 pgkaageVSTDNVIVRKYDAAGELLVE-----------------------------LPDEEAQRYALGV-RryEFDWGLA 140
XP_001730485  80 -------TKEKDVLSRTYDPASDAWLTp----------------------------PGTDASTPLLVSRdHlqSMDKSLA 124
GAC72603      82 -------FESQEIAIRDLDRIHQRLVVpnpdaassaar-------yramrvsrsynAGTSQQLQTVVSQeFlaSVQSRLL 147
CCF54578      76 -------FDEGEASVRELDRAQQRLVApdqlgsgssigr------skqfrtsrtfdPS-SKAISTIITLeVmnSVEPRLL 141
XP_012190670  81 -------FDDDEISVRELDRTEERLIVpdqraspshaasgsaigrskhrrlsrtidPTSSPLEATLITPdVlsSVEPRLL 153
KIS71263      81 -------FDDGETAVRELDRLQQTLVVpdqllscstavstssstrpkryrksramnASGVQTVSMLVTPeVlsAVEPRLL 153
EST06231      75 -------FDEGEVVARELDRGQQRLAVsgsgrstr-------------rrvsrtidPSASR-VATIVTPdVrgSVEERLL 133
Q5KPA5        81 -------FSAKERYAVHYDKDTENISL---------------------------------PENGTVISDdNlkTLDKELA 120 Cryptococcus ne...
XP_012740529 144 ----rrpGEPGEIFVKKWDRNTETLEDe----------------------------DSAVEIRRQKDNI-QssYGT--LL 188
EDN90691     234 ----lasDEYGDAHVLRWDNYHECLEEe----------------------------VSEAEKRIQKASI-PeiVNR--LE 278
XP_002948987 141 PYNLHAWR--------------------------------QWRELTSCLD-------ERIIDAIQP--VGVNICTAAEAe 179
XP_001730485 125 PYPVDDYA--------------------------------LWQSMTRYLQk-----sRATLARIFHvdAHTGDAMCDSFt 167
GAC72603     148 PAPEEAQQ--------------------------------RWRKATQHLGcaggaigRKVVARVVGidLESGDASTDSMt 195
CCF54578     142 PYPSAARK--------------------------------PWQDALRHLSvdngrvgRKVVVRVLGvdVHSGDSNTDSLa 189
XP_012190670 154 PYSVEARE--------------------------------LWRKATLHLSrdqgrvgRQIVARVLGvdASTGDSTTDSLa 201
KIS71263     154 PYPEDAGH--------------------------------MWRQATRHLSldrggmgRQVVARVVGveIASGDFTTDSLs 201
EST06231     134 PYPTTAGD--------------------------------SWRAATRHLSehgghvgRQVVAKVLGvdSE-GDSITDSLa 180
Q5KPA5       121 PYPFERFE--------------------------------AWKSLTSHIT-------PTILQSVIGpdGKVDGL------ 155 Cryptococcus ne...
XP_012740529 189 PYDVRAVqtselsksrgn------------paeshgddpktWQDLTFAIK-------GPMLSRVTGgtw----------- 238
EDN90691     279 PYlsntsvpspkpagsvstsptfvnfpsspiaaediygsdkWRHLTSCIK-------HPYLKRVTGgkw----------- 340
XP_002948987 180 ldeqdgggggaggvegrprteaearlrqqllegrtarkaaaaaaaavqpppppaavpeapppppppppptaatsapgdrt 259
XP_001730485 168 smsd---------------------------------------------------------------------------- 171
GAC72603     196 sgprrsndpkeeeaf----------------------------------------------------------------- 210
CCF54578     190 tgpsrardgleqtsi----------------------------------------------------------------- 204
XP_012190670 202 tgpstareitneetl----------------------------------------------------------------- 216
KIS71263     202 tgpsrwndakeeeql----------------------------------------------------------------- 216
EST06231     181 agpaqaadgkeetvl----------------------------------------------------------------- 195
Q5KPA5           --------------------------------------------------------------------------------     Cryptococcus ne...
XP_012740529     --------------------------------------------------------------------------------    
EDN90691         --------------------------------------------------------------------------------    
XP_002948987 260 sgpsdmevedggggggggggglergtmhaVAAAAVAARGTASvdngstSATEGGGMKSSTSSGRCF-------------- 325
XP_001730485 172 -----------------------------------rearVNVhdlrhtYRSQMQGKASSPMSSVPSl------------- 203
GAC72603     211 --------------qrtgnvgrnengitiWGNSQPAHSH---------VEVESDGEGSAEEATERIigaenrkrkrtenh 267
CCF54578     205 --------------qhtgnlgrsengkiiWGKSRPESEREALelfgvvAADDDEEKYDFAAKEEteskkrkrssptsn-- 268
XP_012190670 217 -------------shpgstsgrkedgkliWGKSRP-QAEITE------VAVDGEDACAENDLAKsttrkrsfstel---- 272
KIS71263     217 -------------qrttgalgrkedgkliWGKSRRLQAKTSE------VEVQDDMENGVEDAVEhksrkrsasies---- 273
EST06231     196 --------------qqsgnsgrrehgkvvWGKSRPEAERFE-------VLADGDETDEGDPAqtskkrsnpds------- 247
Q5KPA5       156 ------------------------------------------------MPVIDQEEDTLTRDMREKleeikrrsq----- 182 Cryptococcus ne...
XP_012740529 239 ---------------------------ndWKVTS-------M------DERKPTDTKPADNQHQTAmgivpkpadid--- 275
EDN90691     341 ---------------------------nsWKVSS-------S------HDIKTTELQATSaprdvkgnst---------- 370
XP_002948987 326 --------------YSVVPRlVKEA-GLTAAQLTALNMDRSAQLEALAVNRWGGd------------VAAVVGEMQFAFV 378
XP_001730485 204 -------------aFTPFSLaHSWPpDAHGAERTRWSMDKSWLLEDVMSRACAAehhg-----sslaHEPLLREFELSFL 265
GAC72603     268 ategaeesddgvllFTEFDLrRSWPpNAVGAELTRWSQDKSWLLRDVAARARRGiasded--tqsgwYLPLLCEMELAFV 345
CCF54578     269 gktsgilddedsllFTTFDLqRSWPpNSIGADITRWSEDKSWLLQDVACRSRSSise-------ddcYLPVLCEFELAFV 341
XP_012190670 273 ---tedadddeallFTSFDLrRSWPaRSIGAEITRWNEDKSWLLQDVTRRSHLGiaqsvn--retswYLALLCEFELAFV 347
KIS71263     274 ---iegerddgqlaFTRFELrRSWPaNSIGAEITRWSQDKSWLLRDVARRSWLGishsaysadgdgwFVGLLCEFELAFV 350
EST06231     248 ----tedaddealhFTPFDLrRSWPpHSTGSDITRWSQDKSWLLRDVARRSSTGiippsl--eanneWSALLCELELTFI 321
Q5KPA5       183 -----nfgftkslmFVRFSLkKSWRdGAVGEEVTVYSKDKSWLLGNVIDEQLDRn------------PTALLGHLQLSFI 245 Cryptococcus ne...
XP_012740529 276 ----atiaeekklgFIFPAGsKTYSeAAIGRARSEQAMDSSSHVRAVIADGCts-----------dgPDDVLGELQFCYM 340
EDN90691     371 -----nfdgddflnFVFPRNsRTFSdASTGRERTEQAIDSTAYIVEAIAN-Cty-----------edSDEIIGELQFCYI 433
XP_002948987 379 AFVYGQSLQSFYQWRSLVTLFLNCEAAaLGGKSRHaa-----------------------tFAAFLAALRAQLACALAdt 435
XP_001730485 266 LFRCTNNAAALDHWAAIISLFCRAASY-LGAPAPHalhpcewdadrpasapmvtssshleaHLGWLEALVAQWQALPP-- 342
GAC72603     346 LFVMASNVHAWDEWKDLLSLFCRAASI-IGSQSAFhlhpasidassaqlmdvdveqvrvdaHVAFLDTLAAQLDLLDG-- 422
CCF54578     342 LFVSASNSYVWEQWKDLVALFCRSSTL-IGASSAFqvhpsqtgsps-----vvptqirldsHIAFLFTLRSQLALLQP-- 413
XP_012190670 348 LFITANNAYAFDQWKDLIVLFCRSSSL-IGAQSAFqlhpsaatsmsd---fqndtavdltaHIAFLTTLHTHLLILPT-- 421
KIS71263     351 VFITANNAYAFEQWMDMVALFCRASSL-IGAQSAFqlhpstqissp-----rtdrdihlnaHIAFLNTLHTHVFILPT-- 422
EST06231     322 IFIAAGNGYAWQQWFDLVAVFCRSSSL-MGAQSAFelhpstt-------------ptdltpHIAFMSTLRAQLVLLPI-- 385
Q5KPA5       246 FFLQISSYSSLLAYQRILALLCQSSSF-LISPSTFlsppkrnpna-------hvgegmkiiYKELLKTLRVEIEALPD-- 315 Cryptococcus ne...
XP_012740529 341 TGVLLSNICCMEQWGHVVKILFKAFRF-AVEEAHF--------------------------FTKVIEVFQAQLVYDDE-- 391
EDN90691     434 TGMVLGNLACMEQWGIIISKLFGAYRL-SMDHPVF--------------------------FRKVITAVHAQFMYDEE-- 484
XP_002948987 436 adsaagvleskeDLVAA--ATHgsssllveevllagggRDCFLRRHLDSWFEVLRE-------------AEPGevdSRLL 500
XP_001730485 343 ------------HIWTDdlAS-----------------YEAPILDDLACLRANIGRslsaw----aamtSSTTtdhERLV 389
GAC72603     423 ------------EFWSNqsTAK----------------EEQAVLKELDVLRANIARslalag--tvqaggGDEegrARLV 472
CCF54578     414 ------------DFWSTqtSFA----------------EERAVLKELDTFRSNLARslsaasiqhtdpgAQLEekrEQMV 465
XP_012190670 422 ------------DFWSSqsTTQ----------------QETHLLKQLDVLRANIARslstps---qlqhkVDEahrEQLV 470
KIS71263     423 ------------DFWSSqsTTQ----------------QESQLLKNLDILRANIARslstpc---hyqhtVDEdqrEQLV 471
EST06231     386 ------------DFWSTqeGK-----------------EEQTLLAHLDALRVNIARslsaaa---stgttKEEeqrQALV 433
Q5KPA5       316 ------------GVFDTelPE-----------------MDVFYLDQLESLRKNLASaiwge---veegtTWTElerQSFK 363 Cryptococcus ne...
XP_012740529 392 -------------------YLQgsifdhs-------nhlqdeLKVELTIFKSRLSEqls-------skpNGLSreeNKLK 438
EDN90691     485 -------------------GFDtsifdhd-------shlgddLKIILTKFKSRLNEqll-------sngSKITpeqEEVG 531
XP_002948987 501 YEATQLRALLSRTVGWQFD 519
XP_001730485 390 NAWRDLSSISHARFAWSLD 408
GAC72603     473 AAWRKVSHLAASKFGWQLD 491
CCF54578     466 TAWRTLSHLTASRFGWQLD 484
XP_012190670 471 KAWRSLSHTTASTFGWTLD 489
KIS71263     472 KAWRALSHTTSSRFGWSLD 490
EST06231     434 QTWRALSHTTATAFGWQLD 452
Q5KPA5       364 SLWNALRDSAWKKWKWDID 382 Cryptococcus neoformans
XP_012740529 439 ATFGRLETWLS-KWGWDLG 456
EDN90691     532 KAFEAFESWLW-KWGWDLR 549
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