6EHP


Conserved Protein Domain Family
LAMTOR

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pfam15454: LAMTOR 
Late endosomal/lysosomal adaptor and MAPK and MTOR activator
LAMTOR is a family of eukaryotic proteins that have otherwise been referred to as Lipid raft adaptor protein p18, Late endosomal/lysosomal adaptor and MAPK and MTOR activator 1, and Protein associated with DRMs and endosomes. It is found to be one of three small proteins constituting the Rag complex or Ragulator that interact with each other, localize to endosomes and lysosomes, and play positive roles in the MAPK pathway. The complex does this by interacting with the Rag GTPases, recruiting them to lysosomes, and bringing about mTORC1 activation.
Statistics
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PSSM-Id: 464726
Aligned: 48 rows
Threshold Bit Score: 45.3382
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6EHP_E         5 LLLDPSSPPT---K----ALnGAEPNYHSLPSARTDEQALLSSILAKTASNIIDV-SAADSQG-MEQHEYMDRA 69 
EGC49460      23 LLDDDLYQSGyg----ygAVgSVHR-QGPDPEYLKREREVLEAICQRTSDSVIDIwAIQSSQ--LPGHTSSSIN 89 
XP_001268056  23 LLDDDIYQSGyg----ygALnHANQLTNPDPENIKREREALEAICQRTSDSVIDIwSLQPQPHlQPRATLHgsv 92 
EKV12519      49 LLDEDPYQAGyg----ygALhQAHQASQPDSEYVRREREALESICQRTSDSVIDIwSIQPQPHlRPQATLHtpi 118
Q5BCG8        23 LLEDDIYQPGys----ygALnHNQQANQPDPGYVRREREALEAICQRTSDSVIDIwSLQPQPHlQPQATLHNSV 92  Aspergillus nidulans
GAD93581      23 LLDDELYQPGyg----ygALnQAHHLNQPDPEDLKREREALEAICQRTSDTVVDIwALQPQPHlQPRATLPSTS 92 
XP_002340781  23 LIDDDLYPGGyg----ygSInNANQ-QQSDPEDMKREREALEAICQRASDTVIDIwALQSQPNfQPRATLPSID 91 
EHY58159      23 LLYDDYPSSH---GygtwATsNIPSQNVMSQEEVQREQEALDNITRWASDQIVEIfPHQHRNLaMSAVSSQFng 93 
XP_001936910  22 LLGDQYQPNYg-------TSsSNHNVPQPDPEELRRQRENLERICAETNEQLIPV----SQPSaLPEVSEQPKN 84 
CAZ83359      21 LLAAPNDHLHshsYtngnFAnSSHHHSIPDPQALLHEREYLDRLVAQTSENLIDI---------FAPPTLTHSN 85 
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