5WN8


Conserved Protein Domain Family
IDO

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pfam01231: IDO 
Indoleamine 2,3-dioxygenase
Statistics
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PSSM-Id: 460123
Aligned: 176 rows
Threshold Bit Score: 375.336
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
5WN8_A         1 MSKEYHIDEEVGFA-LPNPQENLPDfYNDWMFIAKHLpd-----------------lIESGQLRERVEKLNMLSIDHLTD 62   human
XP_001833050 130 SPYSYDINQHTGFFpPE-PLPKLPPsYEIWEQALRDAngnlslged--esedalerrPYGLEWRARIQEWPVLDTAPLHK 206 
EDR14354      41 SPAAFDVDSRTGFFpRQ-PLPKLPHtFDIWEDALRNAdgnlslged--esetalakrEFGARWRETIQSLPVLDTSVLHT 117 
XP_003027519 100 DLPEFDIDGETGFVpPR-PLPRLQGdYQIWEDTLREAagrvslgcd--esdeaisrrAYSKSWRQKVDSWPVLDTSDF-- 174 
XP_003034864   1 ----FDVDANTGFMpRR-PLPKLRGkFDLWEAALRSAtetlvlgsd--eseeaaqkhPQGSRWRKAIEQLPVLDVDELTC 73  
XP_007326091  39 SPSDFDIDLQTGFFpTT-PLSRLPSsFDLWEDGLASAagrlplgnd--sseealarrEFSRNWRDDVKSWPVISIQELGS 115 
EPS99019      17 NPSDFDVDSKSGFFpPA-PLPRLPSeYDAWEAAFAAApsvialagd--kseealqkrGDGASWRSTVRSWPVKDVCILCG 93  
EMD38214      25 EPEEFDVHPQSGFFpPQ-PLQKLPEaFGIWEQLLADAhscltlsnd--yseeavakrPKGELWRNRVRDMPLISIVNLTE 101 
ELU40446     123 SCFEF--DAQTAFMpPEPPLSRLDGdYEQWELLLDAAftnftcpgd--eesvpesqvQFGECWRQSVRKLPVLSIQPLEF 198 
ELU40413     158 ACPEFGLDSKTGFLpTQVPLARLPAaFNKWEDALQQAmvilkrpgdsddppptdeerEQSSRWRENLRT--VISIDPLQV 235 
5WN8_A        63 HK-SQRLARLVLGCITMAYVWGk-GhGDVRK------------------VLPRNIAVPYCQLSKKLELPPI--LVYADCV 120  human
XP_001833050 207 NPrLAQRAHLVLAWLVSFYVHSi-P---PTTstantssgsdsedraeplRVPKSLAVPLMQVSRHLGLAPV--LTFADTV 280 
EDR14354     118 NLrLSQRAHYVLAWLVNLYVHSi-Psssdd---------------sdpvHVPKSLALPLVQVSRHLGCAPV--LTFADTV 179 
XP_003027519 175 GLkEQQRAHYVLAFILHYYAHSi-Pdddmd--------------kcspiHIPKSLSKPLVAVSRALRIAPV--LTYADTI 237 
XP_003034864  74 DLrLLQRAHYVLAYLIHFYVHSi-Pdgele--------------pgapiTIPRPLAAPITAVAQHLRMAPV--LTYADTI 136 
XP_007326091 116 DLrLLQQAHYVLSWLVHLYVHSv-P---LDPtle-------------viVVPQSIAVPLVEVSKILQIAPV--LTFADTV 176 
EPS99019      94 DIrLLQRAHMVLASLMHFYVHSl-P---SSda---------------aiLVPKSISVPLVEVSRELGIAPV--LTFADTV 152 
EMD38214     102 NSq-LQRAHMVLAWILHFFIHSm-P---QSEkep-------------qvRIPQSLAVPLVEVSKILRIAPV--ATFADVV 161 
ELU40446     199 DLrRARRAHHVLAFITQFYVQSlpP-RDCTFdrp-------------piIIPAPIAIPFVGVSRQLDIAPI--VTYADTV 262 
ELU40413     236 DLrVAQRAHHVLAFLVQFYVQSlpP-RAETelg--------------piHIPRSLAIPFVDVSRYLDIAPIrqLTYADCV 300 
5WN8_A       121 LANWkkkdpnkplTY---ENMDVLFSFRDGDCSKGFFLVSLLVEIAAASAIKVIP--TVFKAM---Qmq-------eRDT 185  human
XP_001833050 281 LWNWeli---hpsRPlspDNIRFVNTFSGTDDEKNFYYASALAELRGVEILRIIDdfNNL-Pig-sDla-------sTTK 348 
EDR14354     180 LWNWeli---dpdQPlsiDNMQFVNLFSGTEDEKSFYQASAKAELRGVELLRIIDdyNSL-Pni-tDlt-------sISK 247 
XP_003027519 238 IWNLeli---npdGPttpDNLQNETLFSETEDESAFYMSQVNCELRGAELLTCMQelSQMTKEdakNpd-------nLPC 307 
XP_003034864 137 LWNVeki---nedGPltmDNLRTETLFSGTEDESAFYMSQVRCELRGAELLGIMAdiANLPPLrarDaa-------mVAE 206 
XP_007326091 177 LWNYeli---npaEPlsvNNIRFRHHFSGTEDEDAFYLSSARAELVGVEMLRIFDeyGRLSPna-gDyt-------aVGK 245 
EPS99019     153 LWNWeli---dpsLPvevNNMRYLNVFSGTETERAFYLSSAAVELRGVEMLDIFNrfQNLPASshtDah-------vIAQ 222 
EMD38214     162 LWNYeli---dptLPltpQNIKYDNLFSGTETERQFYVVSALVEMKGVEMLKIFEdfYNL--QdptTps-------aVEK 229 
ELU40446     263 LWNWeli---epsQPmssSNIRIKDLFTRDPQEEHFFLTSARIEIRGLEAMDIMAkcLRQIEEgvtSea-------eQVR 332 
ELU40413     301 LWNFyle---dpsKPltlENIRIRDLFTKDYQEEHFFLTSARIEIRGFEAIQLMGdaIam-----tRkaqnldvvvdEIR 372 
5WN8_A       186 LLKALLEIASCLEKALQVFHQIHDHVNPKAFFSVLRI-------------------YLSGwkGNPQ--LSDGLVYEGf-- 242  human
XP_001833050 349 VSRDLHRLAGIIEDITEIITSVRSACDPHVFYWDIRP-------------------WFEG--SDAKgpGGPGWIYEGvde 407 
EDR14354     248 VSRDLGRLVGIIDDISEIIQSIRPLCDPHVFYWDIRP-------------------WFEG--SDAKgpGGPRWIYEGvdd 306 
XP_003027519 308 VSCMLTRLKLVIEDLDKLIKSVRPLCDPHLFYWKIRP-------------------WFIG--STKEh----pWIFDGeep 362 
XP_003034864 207 VEGALRRLSGDIDELTEVMKGIRPTCDPHVFYWQIRP-------------------WFVG--SSEEh----pWVFEGada 261 
XP_007326091 246 VSRDLIRLSGIVDDINEVIKSVRPTCDPHVFYWQVRP-------------------WYSG--Sg---sDGPRWKYEGvpk 301 
EPS99019     223 LAKDLNQLAVIVNQLTEVFRSMRETVDPVEFYWAVRP-------------------WWSG--ATSKgpNHPGWILEGvpn 281 
EMD38214     230 IAVDLVQLKKIVDELTEIFRLIRTTLDPNIFYWKARP-------------------WWSG--AKNTlkKME-WVFEGipd 287 
ELU40446     333 LASNLTRLAQVVDDITTILDAVREGCDPMFFYFTFRP-------------------WIRG--ADQGa-DSPMWFYEGvdg 390 
ELU40413     373 LQSILARLAIVIDDLNQILWSVKDACGYQFFYWVFRPvsslfrngwqvklilnthqWIRG--TDQGy-GSPKWLYEGvdg 449 
5WN8_A       243 ---wEdpkeFAGGSAGQSSVFQCFDVLLGIQQT--------------------A-------------------------- 273  human
XP_001833050 408 --aeNl--dLSGPSAGQSSVMHALDIFLNIDHKlqer------------rypaPs------------------------- 446 
EDR14354     307 --feKl--dLSGPSAGQSSVMHALDIFLDVDHKlrqr------------rypaPs------------------------- 345 
XP_003027519 363 --gsDl----lGPSGGQSTLMHAIDVWLDVDHMlryk------------rvpePc------------------------- 399 
XP_003034864 262 --gdDl----lGPSGGQSSLMHAIDVFLSIDHElrys------------rtpaPt------------------------- 298 
XP_007326091 302 --deKl--lRSGPSAGQSSVMHALDIFLGVDHK--------------------Kg------------------------- 332 
EPS99019     282 gdsaHf--dLGGASAGQSSAMHALDVFLDIDHRlatk------------rapaPs------------------------- 322 
EMD38214     288 --saVl--dIGGGSAGQSSVMHALDIFLDIDHKletk------------rsppPs------------------------- 326 
ELU40446     391 -qgiEm--qCSGPSAGQSALMHAFDVFLDIVHPnsrasrgcsfainfpitppsSpgmhgkdindisqcpfaskistvd-- 465 
ELU40413     450 -egiEf--qCSGPSAGQAALMHAFDVFLGIGHPqkddrysptctgmrvhpsyvPhgnsqacpasstssastnacpvtges 526 
5WN8_A       274 -------------------------------------------------------G--------------------Ggha 278  human
XP_001833050 447 ------------------------------------------------------pEn-------------------Krad 453 
EDR14354     346 ------------------------------------------------------sEn-------------------Krad 352 
XP_003027519 400 ------------------------------------------------------eAn-------------------Krad 406 
XP_003034864 299 ------------------------------------------------------aEn-------------------Rkad 305 
XP_007326091 333 ------------------------------------------------------sTg-------------------Kdgh 339 
EPS99019     323 ------------------------------------------------------ePn-------------------Rrad 329 
EMD38214     327 ------------------------------------------------------eRn-------------------Lqse 333 
ELU40446     466 --------------------------------paynphvqssrtqadtgldtpplTplesevpt----vipvdlkiP--- 506 
ELU40413     527 spsfadisdelrsflleeaayptppaektelsitlplkplslerslnlptppsspYespvlnpvssrgevpklqpqAdld 606 
5WN8_A       279 AQFLQDMRRYMPPAHRNFLCSLES-N--PSVREFVLSKGDAgLREAYDACVKALVSLRSYHLQIVTKYILIPASQ----- 350  human
XP_001833050 454 HGFMERMRRYMPGQHREFLNVL-StS--RSIRQLAQSTPA--LRDAYDTAVTALKRLRDTHIRIACLYVVTMSRStpgsr 528 
EDR14354     353 HGFMERMRRYMPGKHREYLSSLAAtP--RPIRQLAQSTPT--LREPYDNAVLALKRLRDNHIRIACLYVVTMSRTepgar 428 
XP_003027519 407 LGFMRRMWRYMPGVHRDFLEYLEAaP--VRLRNLAQEVPA--LLEPYDAAVMAMKRLRDAHIGIAVLYVVSAAKElppgc 482 
XP_003034864 306 TGFMRRMWRYMPGAHRDFLEHLEQaP--FRVRDLAEETPV--LRDAYDDAVAALKRLRDNHMRIAVLYVVSAGRSlppgc 381 
XP_007326091 340 GSFMERMRLYMPGKHREYLISLSClS--RSLRELAKEESI--LRESYNSAVAALQKLRTEHIKIACRYTVSMAHTqpnsg 415 
EPS99019     330 LGFMQRMQRYMPGKHRAYLTHL------RSVRPLVERTPS--LREPYNTAVEALKRLRDFHLRIVAIYVVTKAGStppe- 400 
EMD38214     334 LGFMERMRRYMPGKHREYLEHMASvR--PTVRDVAQNVST--LVVRFDEAVLALKKLRDLHIRVVTLYVVNQTRS----- 404 
ELU40446     507 -----RMRKYMPGGHQLFLDHLRSlKfgPTIRALAQDSTH--LANSYNVALQALSGFRDAHIRVVTRYVICPARSktvv- 578 
ELU40413     607 TSFIVRMRKYIPGNHQKFLLHLAH----SSVRPHVAVCASSgVRRAYNDCVWAIKRFRDTHIKIVTLYVIHPARSkvlv- 681 
5WN8_A       351 -------------QpkenktseDPSKLEAKGTGGTDLMNFLKTVRSTTEKS 388  human
XP_001833050 529 ggcpaaamierlhAnr------lAGKGPVRGTGGNELSILLKAGRDATRRA 573 
EDR14354     429 ggcpasamidrlrEsr------lSGRGPVRGTGGNELSLLLKAGRDATRRA 473 
XP_003027519 483 pls---mmakameAkg--------pEGKSKGTGGSEVSTLLKAGRDATRRT 522 
XP_003034864 382 pls---amarameKkg-------pSGGRSKGTGGSEVSALLKAGRDATRRA 422 
XP_007326091 416 cpv--lsawnqtpEg--------eKRKKTLGTGGNEVVTLLKHGRDATQRT 456 
EPS99019     401 ----------rfaPesegdavgTRKDGPARGTGGSEVSNLLKAGRDATKRA 441 
EMD38214     405 -------------TpsaglvseVQNEGPARGTGGSSVSILLKAGRDATARS 442 
ELU40446     579 -------------------rdpALDSGSVRGTGGTSLVPLLKVYRDETLHR 610 
ELU40413     682 -------------------kdtDSESAPVRGTGGTSLVPLLKAYRNNTANT 713 
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