Conserved Protein Domain Family
bHLH_TS_HAND2

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cd11471: bHLH_TS_HAND2 
basic helix-loop-helix (bHLH) domain found in heart- and neural crest derivatives-expressed protein 2 (HAND2) and similar proteins
HAND2, also termed Class A basic helix-loop-helix protein 26 (bHLHa26), or deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2 (dHAND), is a bHLH transcription factor that is essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries.
Statistics
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PSSM-Id: 381477
Aligned: 7 rows
Threshold Bit Score: 130.566
Created: 24-Oct-2011
Updated: 2-Oct-2020
Structure
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Aligned Rows:
 
putative DNAputative dimer
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
  • Comment:The N-terminal basic region of bHLH mediates high-affinity DNA-binding to specific hexanucleotide sequences
  • Comment:Based on the structure evidence that Mus musculus myoD (1MDY) basic region binds DNA.
  • Citation:PMID 8181063

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1         #   # ### #    #                 ####                        
P61296       100 RRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQN 161 human
P57102        91 RRPTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDILDKDEQN 152 zebrafish
Q90690        99 RRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLPKDDQN 160 chicken
P57101        93 RRGTANRKERRRTISINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQN 154 African clawed frog
XP_005993037  93 RRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQN 154 coelacanth
XP_007894139  95 RRGTANRKERRRTQSINSAFAELRECIPNVPADTKLSKIKTLRLATSYIAYLMDLLAKDDQN 156 elephant shark
PRD32642      80 RRVTANRKERRRTLSINNAFAELRECIPNVPSDTKLSKIKTLRLATSYIAYLMDLLAQEDPN 141 Nephila clavipes

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