1GP2,1TBG


Conserved Protein Domain Family
GGL
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cd00068: GGL 
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G protein gamma subunit-like motifs, the alpha-helical G-gamma chain dimerizes with the G-beta propeller subunit as part of the heterotrimeric G-protein complex; involved in signal transduction via G-protein-coupled receptors
Links
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Statistics
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PSSM-Id: 238024
Aligned: 27 rows
Threshold Bit Score: 52.2914
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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beta subunit
Conserved site includes 15 residues -Click on image for an interactive view with Cn3D
Feature 1:beta subunit binding site [polypeptide binding site]
Evidence:
  • Structure:1GP2; bovine G protein; hydrophobic contacts
  • Structure:1TBG; bovine beta-gamma dimer; hydrophobic contacts
  • Citation:PMID 8552196
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #  #   #  #   #      # #  ##  ##  #        ##                #    
1GP2_G      9 IAQARKLVEQLKMEANID--RIKVSKAAADLMAYCEAHakEDPLLTPVPa-------SENPFREKK 65  Bos taurus
Q9NFZ3     11 RDALKKQIENMKYQASME--RWPLSKSIAEMRSFIEENekNDPLINAPDk-------KNNPWAEKG 67  fruit fly
585180      8 LQQQRVVVEQLRREAAID--RQTISESCAKMMKYITEHeqEDYLLTGFTs------qKVNPFREKS 65  fruit fly
CAB53059   28 VPQMKKEVESLKYQLAFQ--REMASKTIPELLKWIEDGipKDPFLNPDLm-------KNNPWVEKG 84  human
7498606     3 KSDMQRTVDSLRSQLNIE--RTPITVSAAELRRFTESQ--EDPLVNPIDk-------KVNPWAEKS 57  Caenorhabditis elegans
1706621   334 QDTLKLEIVQLNSRLSKN--VLRTSKVVENYLAYYEQRrvFDPLLTPPGsqadpfqsQPNPWINDT 397 Caenorhabditis elegans
7496101   204 AQGYRCLMDRLRFAIKTKp-WLKALKASDTMVTWVDQRaeFDPFLHPPQ--------PSNPWISDE 260 Caenorhabditis elegans
8489000   219 VTAVRKEIMYYQQALMRS--TVKSSVSLGGIVKYSEQFssNDAIMSGCL--------PSNPWITDD 274 Norway rat
7293293   429 VEQLTRIIALRKQKLERR--TIKVSKAAEALVAYYDQYneFDYFITSPE--------LPNPWQTDS 484 fruit fly
CAC42816    6 LKKVLKENETLKAQLEKSttILKVSEACESLQDYCTKT--SDPFIPGWS--------GENEWTKPL 61  Dictyostelium discoideum

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