Conserved Protein Domain Family
Muted

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pfam14942: Muted 
Organelle biogenesis, Muted-like protein
The protein is a coiled-coil protein and belongs to a family found in eukaryotes. It undergoes alternative splicing forming two isoforms. The larger isoform is 187 amino acids long in protein sequence length and 21 kDa in mass. The smaller isoform is 110 amino acids long in protein sequence length and 12 kDa in mass. This protein associates with other proteins in order to form biogenesis of lysosome-related organelles complex-1 BLOC1 complex. BLOC-1 is required for the normal biogenesis of specialized organelles of the endosomal-lysosomal system.
Statistics
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PSSM-Id: 464390
Aligned: 30 rows
Threshold Bit Score: 106.199
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015789225   2 FAIVDEIVTRLLDHRCFTSGELKFFTQQFEETrnNHEVKQVDQIEKCIKDLSENDLPMAKDKlEKSNLFEIE--PNIDDL 79 
ESN98678       9 TPSASDVYHRLFDHRAAIQGEINYFLDIVEEK--DDGLVRMKSMRNTLNNLDKNVFPSLMNS-LELHMKSLNdsSKIVGL 85 
XP_002117101   7 FKDTSAIYARLFDHRAAIHGEVNHLIKELEIKrnDRELMLLNKCHEKTRHVQIQLHPECVQY-LQHQIESAA--EKINDL 83 
EFN73799       2 FVDTGEIWSRLFDHRPFVQGEITFFLREFQEKraDREVERLFKILEYSTELKESQLDRTEQL-GDCHLPSLK--ANVDVA 78 
3_pfamImport   1 IKDCGEIWNRLFDHRPFLNGEIK-------ESrgDREISRLFEIHELVTDFRDTQIPKTCEK--ENTLNKLN--VLLDIS 69 
XP_002400260  11 VKDIGEVHSRLFDHKPFLQGEIKYFIKEFEEKrnDREVQRLFEILENVTEIRETQIDRICRN-SDQKLCNLT--GNLEVA 87 
XP_002000883  17 GRELYKVPHRILDHRVFINGEIDIFLDNFELKrnDSEVETLFQVTEIVGSLKYDLSERCIAL-GNQRLTELS--TAVNNL 93 
XP_001954048   6 GRELYKVPLRILDHRVFVNGEIESFLDNFETRrnDSEVEKLFQVTETVGSLKYDLSDRCIAS-GSQHLTQLG--SEVNQL 82 
XP_004932351   7 SREIGEIWSRLFDHRPFLNGEIKYMLKEFEEKrgDREVENLFKILEKITEIKDNESERIRKS-GHNALPVLS--EKLEQA 83 
EEB20463      30 FKDIGEIWTRLFDHRPFLNGEIRFILQEFEEKrgNKEVERLFAILQNITEIKYNQIDSIKLK-ADENLETLQ--NKIDDS 106
XP_015789225  80 LEQATELIDMEHKEEKRRNRKLAEi-iIKYEAEKSLVIKETQTKIADLDTIYADKANDLKKYYKElEAKW 148
ESN98678      86 TNDVDHLMTEVDKIDYEKISNIEN---VKSESRMLLFEKEIAVKKENIDEEYNKELEKCKSYYDQ-QEKI 151
XP_002117101  84 TQNLSEMIKKDSSEEVTETRPRSEsvaDEFAAEWDEFMREMNEKCQKVDNEYNEKMKHLSDDFSElK--T 151
EFN73799      79 LSMCSRVLQR--EENFDSDSVLNEn-rLARRKEWEKFINDMSDKCQRVDQTFQEKENEIQEFYVDlEKKL 145
3_pfamImport  70 LQNCAIVNEN--KEKYSQNQTLEAk-rALRKTEWENFMKDIRCKYSNIDKTFKEKEDELKEFYDDlEKKL 136
XP_002400260  88 LSMCNKILEA--EDKINVAEDLSEr-rKQRQCEWEKFMQDIKDKTARMDEAFQQKEREVIDHFRClQEKL 154
XP_002000883  94 LNGVETLLEK-AKVERKPSVELQEa-rRAREQRKAEFLSNLQHNYKRIDNSFEEKEEEIAELYSDlQLKL 161
XP_001954048  83 LEGVNDLLAK-AKVERTASTQLQEa-rLAREKRRAEFLTNLEHGYRRIENSFEEKEEEIAELYSDlQLKL 150
XP_004932351  84 LNLCEELEKDYLETQKVCQKQIKSn-qELRKREWDKFIDDMNFKCQRIDNAFEEKEEELRDLYADlKHKL 152
EEB20463     107 LVVCNTILQE--EEQYRTDTTILKn-kERRKAEWDVFIKDISQKCVKIDEEFNVKEKDLRDYYADlDNIT 173
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