Conserved Protein Domain Family
AGTRAP

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pfam06396: AGTRAP 
Angiotensin II, type I receptor-associated protein (AGTRAP)
This family consists of several angiotensin II, type I receptor-associated protein (AGTRAP) sequences. AGTRAP is known to interact specifically with the carboxyl-terminal cytoplasmic region of the angiotensin II type 1 (AT(1)) receptor to regulate different aspects of AT(1) receptor physiology. The function of this family is unclear.
Statistics
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PSSM-Id: 461896
Aligned: 12 rows
Threshold Bit Score: 189.123
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q5EBF8         9 KAIVFTHWLLTVFACMIdwLPKAYGLANITILAMGVWAIAQRDSIDAIFMFLIGLLLTILTDILLFALYFTEaeKAsesg 88  tropical clawed...
XP_005618054  30 KMILLVHWLLTVWGCIT--FSGPYPWANFTVLAVGVWAVAQRDSIDAISLFLGGLAATVFLDIVHLSVFYQR--TG---- 101
Q6RW13         9 KVILLGHWLLTTWGCIV--FSGSYAWANFTILALGVWAVAQRDSIDAISMFLGGLLATIFLDIVHISIFYPR--VS---- 80  human
Q642A2         9 KVILLVHWLLTTWGCLA--FSGSYAWGNFTILALGVWAVAQRDSVDAIGMFLGGLVATIFLDIIYISIFYSS--VA---- 80  Norway rat
XP_008273612   9 KVILLIHWLLTTWGCIV--FSGSYAWANFTVLALGVWAVAQRDSIDAISMFLGGLLATVVLDIIHLGVFYPR--SG---- 80 
XP_005986118   9 KAIVVVHWLLTTWGGLSqwLPMTYFWSNYTVLAVAVWAIAQRDSVDAVFMVLLGLLITIVTDIVFFGVYYPRngGR---- 84 
XP_007228563   9 KAIVLVHWLLTIWGCMAm-PPNSYAWGNFSVLAVGVWAIAQRDSIDAVVMFLIGMTATILTDIIHFGIFYPAf-HE---- 82 
XP_005811887   9 KAIVLAHWLLTVWGSMSy-LPSSYAWGNFSVLAVGVWAIAQRDSIDAVLMFLMGMAVTILIDIVHFGIIYPRy-PL---- 82 
Q29H66        16 KLVAFVHFFFISNAMLGswGHGAYEFYNFLFIISMFWAIHCKDSIEAVQSALVIDASSIFFDLVSIIIYFHF-------- 87  Drosophila pseu...
KJE97505      13 RAIVLFHTFLSIWAVLDgyLGTAYFYASFGLSMIGVWALGDQTSLEAITLYAIALVFTMLNDCITMGVYSTK--DIvfnd 90 
EHB16619      29 KVILLVHWLLTTWGSIL--FEGPYSWANFTILALGVWSVAQPDSVDAISMFLGGLLATILLDIIHISIFYPR--NT---- 100
XP_010721213   9 KAIILVHWLLTVWGCMNnsFPASYAWGNFSVLAVGIWAIVQRDSLDAIVMFLTGLLLTVLTDIIHISVYYPLh-SY---- 83  turkey
Q5EBF8        89 pLRDLFRFSSGMGIFSLLLKPLSCFFMYHMYRERGGEYFVNLGFITLSRDRSSYQSIEHMDPP---ADQDNKLPSRTY 163 tropical clawed frog
XP_005618054 102 -FSDTQRFGAGMAILSLLLKPLSCCFVYHMYRERGGEHLLYTGFLGPSQERSDYQTIESPEVP---ADPFVGSEGRGH 175
Q6RW13        81 -LTDTGRFGVGMAILSLLLKPLSCCFVYHMYRERGGELLVHTGFLGSSQDRSAYQTIDSAEAP---ADPFAVPEGRSQ 154 human
Q642A2        81 -VGDTGRFSAGMAIFSLLLKPFSCCLVYHMHRERGGELPLRSDFFGPSQEHSAYQTIDSSDSP---ADPLASLENKGQ 154 Norway rat
XP_008273612  81 -LSDTSRFGAGMAILSLLLKPVSCYLVYHMYQERGGEHLFHSGFLRPSHDHSAYQTIDSPEAP---ADPFAGPESRDP 154
XP_005986118  85 -ITDTLRFSTGMAIFSLLLKPVSCYFIYQMYRERGGEY-VNFGFPVGSQNRSQYQAIDPQDAA---PPPHCHPEQEIK 157
XP_007228563  83 -TNDFIRFSMGMAILSLILKPLSCFFVYQMYRERGGDYNINFGFPTVTRNRDAYQSIDQQDQS---SS-AKPFNQAED 155
XP_005811887  83 -VA-AASFSAGMAILNLLLKPVSCFFVYQMYRERGGDYNINFGFPSVSRNRDAYQSIDQQDES---SSPTNSFNQAKD 155
Q29H66        88 ----MNGWAIAFSIINLILRPVSVALLYREFNTRGGSLQTGSVF--PTSQQRSYQDIDRPTQP---T-PTNSQPGPNV 155 Drosophila pseudo...
KJE97505      91 yAPNARKFSFAMALISLLFKPISLFFALREFNRRGGSLTVP---GITVSSTTNYEPI---GGS---PDPVSQDPNANN 159
EHB16619     101 -ISDTSRFSAGMAILSLLLKPFSCYLVHHMYCERGGELHFHSDFLRPSQERSAYQTIDSTEEP---ADPFAGREARGP 174
XP_010721213  84 -LIDVKRFSMGMAIFSLLLKPGSCYFVYRMYRERGGEYIFNIGLNHAGRDRSAYETIDQQEGSplwPDSSRTAQhsy- 159 turkey
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