7P2P


Conserved Protein Domain Family
SPC22

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pfam04573: SPC22 
Signal peptidase subunit
Translocation of polypeptide chains across the endoplasmic reticulum membrane is triggered by signal sequences. During translocation of the nascent chain through the membrane, the signal sequence of most secretory and membrane proteins is cleaved off. Cleavage occurs by the signal peptidase complex (SPC) which consists of four subunits in yeast and five in mammals. This family is common to yeast and mammals.
Statistics
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PSSM-Id: 461357
Aligned: 94 rows
Threshold Bit Score: 134.612
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
7P2P_B            2 MNTVLSRANSLFAFSLSVMAALTFGCFITTA-FKdrsvpVRLHVSRIMLKNVE---------DFTGPr--ERSDLGFITF 69 
EGF78998          1 MHDLQSRISAIASFFLTVLATQFSLVALLQLvLVfs--kSAIVVNSFEPARVKlvsgrvgggDYYMYg-sPYTNLGVISF 77 
A0BS79            1 MYSITARFNQIVFFTSWTLVVLSLLNQGTAYfFK-------TGKPTVDLKILSadkfqhykaTYYNGg-aTDWDQVTFKF 72  Paramecium t...
XP_001614583      1 MDNVLNRLNVLSYSMALCFFTLCLFNYGTSFyLFd----EKEMSTSIKVKSVK---------RLVYNr-hIKGDEAVLSL 66 
Q8I3A5            1 MDSFLNRLNVLFYSMALCFLILCAFNYGTSFyLFd----EKEIKTNIQVKSIK---------RFVYNr-yINADEAVLSL 66  Plasmodium f...
XP_680467         1 MDSLLNRINVIFYSMALCFVTLCLFNYGTSFyLFd----ENSIVTDVKVKSVK---------RLVYNk-yINGDEAVLSL 66 
XP_002141553      1 MESTLSRINILVCTFVAALATCAAGNFVTSLfYKp---nPSGVVEFHSVLDIG-------------IspyLRNDQANIAF 64 
Q4UAJ0            1 MMNFLSRSYSVLHAGAMIGLIALFLNYYTGVnLR------TNKHMIGDVKHIK---------THELTldkSKVDRALIEL 65  Theileria an...
jgi:PHATR_18533   1 MHTVWVRLNAVVFFGLTALLGFSCLAALSKLg------hSLRHKPVVEVLKLN---------TLRSLkshGGYDRALLSF 65 
Q57ZR2            1 MHSLWVRVAEICSMAMMSCFTGVMLLVASSIvMSql-qpPKPIIKDFNVGISPlvqtrlplvFAQGEyppPMQDVLLVGI 79  Trypanosoma ...
7P2P_B           70 DITADLENIFDWNVKQLFLYLSAEYSTKN----NALN-----QVVLWDKIVLR-GDN------P-KLLLKDMKTkYFFFD 132
EGF78998         78 DLDADLSSYFQWNTKLLFVSAIVEFTNSQ----YHVN-----QAVIWDDLISD-KED------A-VIVLKNQRHeYQVHD 140
A0BS79           73 SLEADFEPVYNWNLKQLFLYVNVHHEHQQk---GYES-----DCVIYDKIISR-PDDpsswstSsKLVLKNQRAeYPLKD 143 Paramecium t...
XP_001614583     67 DLSYDMSKAFNWNLKQLFLYVLVTYETPE----KVKN-----EVIIQDYIITN-KKM------A-KKTHKNFFTkYSLKD 129
Q8I3A5           67 DVSYDMRKAFNWNLKQLFVYVLVTYETPK----KIKN-----EVIIQDYIVKN-KKQ------A-KKNYRNFITkYSLKD 129 Plasmodium f...
XP_680467        67 DLSYDMTKAFNWNLKQLFVYVLVTYKTPE----KAEN-----EVIIQDYIINN-KKS------A-KKTYKNFITkYSLKD 129
XP_002141553     65 NMKISLKDIFQWNTNQLFVYVYATYQNQD----TPIN-----NVIIWDHIISNpKLD------A-NSDLIGIINeYPIRD 128
Q4UAJ0           66 NMRYDLRGAFDWSTHMIFIYVTANYITNR----HERS-----EVIIFDKIINN-KSE------A-YQPSINIFAkYFLYD 128 Theileria an...
jgi:PHATR_18533  66 DLMVDLAPAFHWNIKQLFVYVVAIYETEG----R-NN-----QIVLWDKIVEA-DDE------K-VIDEKNVFVkYALSD 127
Q57ZR2           80 SLKADFSAVWDWNTKHMYVACIGRYHTKSnmtvGGVNlqkthDVTIFDKVLRS-KEE------AaNWTLDNAKK-YALEN 151 Trypanosoma ...
7P2P_B          133 DGN-GLKGnRNVTLTLSWNVVPNAGILPLVTGS---GHVSVPFPDT 174
EGF78998        141 LTN-SLAN-SKANLTLQLQVVPWVGVMRTYRHV---VADGITFPDA 181
A0BS79          144 IHK-QLRN-ATVNFEVWIEVMPYVGYIRREKL----GDFEYKMPQQ 183 Paramecium tetraurelia
XP_001614583    130 YNN-GLRN-NNINLQVCYKYMPIVGLSRSYEG----AKISYKLPAE 169
Q8I3A5          130 YYN-GLRN-NLIHLQVCYKYMPIVGFSRSFEG----AKISYQLPPE 169 Plasmodium falciparum 3D7
XP_680467       130 YYN-GLRN-NLINIQVCYKYMPLIGLSRTYHG----AKTSYMMPDE 169
XP_002141553    129 IGR-HLRN-QKFKLNIAYCYMPIVGFIHYKQLG---TSKMAKLPSH 169
Q4UAJ0          129 FGR-SLRN-RDISLKFFYELVPIGGFIKQYQL----SHNKFTMPKQ 168 Theileria annulata
jgi:PHATR_18533 128 QSD-QLRGk-DVTLQLQWDHMPITGLLYMDGQAv-eSASKFRLPAE 170
Q57ZR2          152 EELgSLAG-AAVELMILYHPMRHYGYSPYYTVQpgkNPVMFQLPTA 196 Trypanosoma brucei
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