Conserved Protein Domain Family
RING-HC_RNF222
?
cd16564: RING-HC_RNF222 
RING finger, HC subclass, found in RING finger protein 222 (RNF222) and similar proteins
RNF222 is an uncharacterized C3HC4-type RING-HC finger-containing protein. It may function as an E3 ubiquitin-protein ligase.
Links
?
Statistics
?
PSSM-Id: 438226
Aligned: 15 rows
Threshold Bit Score: 50.4777
Created: 3-May-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #               #   #  #  #                                               #
A6NCQ9         12 SECPVCYEKFrdlegasRTLSC--GHVFCHDCLVKYLlstrvdg----------------------------qvqrtlVC 61   human
NP_001025635   14 SECPVCYEQLqtn-taeRRLNC--GHSFCHDCLVKYLlsakqeg----------------------------svrkniIC 62   western clawe...
TKS92037       13 QECPVCYESLsg---teRTLSC--GHVFCHDCLVKTLvsitsdg----------------------------nirdtiVC 59   big head croaker
NP_498026      60 ASCPYCQQDFrk----pRVLDC--LHSMCEDCIIAQLdghlqaksaaieekkrataamldceletpkvkerptppgviRC 133  Caenorhabditi...
XP_646616    1107 KICPICFEDEk-----dHVLNC--GHRFCKNCVVDNKl---------------------------------------iSC 1140 Dictyostelium...
NP_510631       8 SRCPTCLEDYddnshrpCVGFC--GHSICLKCQSKIV-----------------------------------------SC 44   Caenorhabditi...
NP_001256597    7 TECIICYNEYdtelrkpCIGTC--GHSICESCKHQMVs---------------------------------------sKC 45   Caenorhabditi...
NP_740943      22 KECAVCYSEMil---ptTIPSC--GHKFCFICLKGVSvsn------------------------------------ngDC 60   Caenorhabditi...
ETO23149       45 VECPVCYNNFs-----gKIFQCmeGHIICEVCLPSVS-----------------------------------------EC 78  
NP_491164       8 PTCPVCQEEFddq-kapFIISC--GHSLCETCIVHLKsdysday----------------------------gsggqtQC 56   Caenorhabditi...

Feature 1           #        
A6NCQ9         62 PICRYVTFLSK 72   human
NP_001025635   63 PLCRYVTFLSK 73   western clawed frog
TKS92037       60 PICRHLTFIKK 70   big head croaker
NP_498026     134 PICSQESHVGN 144  Caenorhabditis elegans
XP_646616    1141 PLCKKEISSDF 1151 Dictyostelium discoideum AX4
NP_510631      45 PLCKRKNAFFG 55   Caenorhabditis elegans
NP_001256597   46 PQCNREEAFAI 56   Caenorhabditis elegans
NP_740943      61 PICRGPIDSQI 71   Caenorhabditis elegans
ETO23149       79 PQCHKPMPKSS 89  
NP_491164      57 PTCRAVVSKEK 67   Caenorhabditis elegans

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap