Conserved Protein Domain Family
Erg28

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pfam03694: Erg28 
Erg28 like protein
This is a family of integral membrane proteins, which may contain four transmembrane helices. Members of this family are thought to be involved in sterol C-4 demethylation. In S. cerevisiae they may tether Erg26p (sterol dehydrogenase/decarboxylase) and Erg27p (3-ketoreductase) to the endoplasmic reticulum or may facilitate interaction between these proteins. The family contains a conserved arginine and histidine that may be functionally important.
Statistics
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PSSM-Id: 461015
Aligned: 122 rows
Threshold Bit Score: 76.3867
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EHA52814      17 PAYLMLVSVLAIGNALQNFT--TLHYSRRIYNGlfvsnpalkrkertdenprhnpedsinklvpasstgkdVEKan---- 90 
EGC36072       5 SNWLIFVALYKFVSFFLIFK-------DDVY----------------------------------------KNQfnrdim 37 
XP_003292932   5 SNWLKFVALFKIISSLLIFK-------EDFY----------------------------------------KNQmnndkk 37 
Q54I19         5 AIWLLMVGLYRVFMSFLILIq-TDVLKKVIYplk---------------------------------------------p 38  Dictyostelium d...
Q552F9         5 QAWLLFIGFFRILCSFVGLV--YPEFMSVGYsrk--------------------------------------------nk 38  Dictyostelium d...
Q54UK5         5 QYFLFFIGCFRLFCSFKFLIn-PVSIFSYAYpnv--------------------------------------------kk 39  Dictyostelium d...
XP_015784257  10 RGWLAFLSFMHVGTAFRCFTd-RDFLRTKIFtst---------------------------------------------t 43 
EFX79779      10 RGWLAFVSFLDFAQALRSWFdkDVFLGSYYKNFn------------------------------------tSTNitdlen 53 
XP_008185879  11 RGWLAFVAFMDLGVTFRSFFenKCIIGTQTNLQade------------------------------------------hf 48 
1_pfamImport   2 RGWIAFVAFMDLGTSFRSYVekRSFIGDHTdn-----------------------------------------------f 34 
EHA52814      91 dQLTPLAARLFAVWTLITGVVRLYTAYDVSNPALYQLSVLTHFLAGGHFLSELLVFKTCRPSVPVL-----FP-IFAGST 164
EGC36072      38 kQVNPLFCRAIQLWLAYTGAVSLLTSYHLDNKDLVFSCFISFLIPFPYLVNEFFIHKTYAK----IhalhvFPlCVTSII 113
XP_003292932  38 kLVNPLFCRILQIWFFYTGVVSLLTTYSLDNKELVLSCFISYLIPLPYLINEFFIHKTYAK----IhalhiLPiCLISII 113
Q54I19        39 iEVSPLFCRMAFMWVISNAILTITTSLNMDNKPLYFITWLTFVIGLSHFMLEQFYFKTNTLKSNLSqlffaTPcLVIMGI 118 Dictyostelium d...
Q552F9        39 qNFSGLISRIFFLWIFTTGSITIACSIDITNRTVYFLTWLTFVTGLGHFLTEYFYFKSNQIKNNLIqlflaLPsIFIMGS 118 Dictyostelium d...
Q54UK5        40 eVFLGLFSRIAFLWFFTTGSMAIACSQDIENKTLFFFTWMTFVYGLGHHVVEYLYFRTTEIKNNLVqfslaFPlIIIMGS 119 Dictyostelium d...
XP_015784257  44 yKNDITFDHLFGIYSIINAIILIQSSIYLYVYPVTRLVICAILAYVSLFTVESFVYKTIQIQQTTL-----FP-FAFSGL 117
EFX79779      54 lPLPSSSARLLIAYSIQNGSILLLSAFCIHHWSMAVMAMFSLLLKIVYLMLEALKFKSTPFNFHII-----FP-VIVDGI 127
XP_008185879  49 iHEELTLPRVLGMFSLLKALCLIHCSLFIHYKPMVSIGAMSMVLSIVLYLSEAIHYRSTTLNFFIV-----FP-SILNGL 122
1_pfamImport  35 iQGDYVISRIVGVYSFLKALVLVHCTLYIHHKPIVSMAICALILTITLYLTEAFYFQSSTMNFYVI-----FP-CVLNDG 108
EHA52814     165 GFI 167
EGC36072     114 GLF 116
XP_003292932 114 GLF 116
Q54I19       119 KLL 121 Dictyostelium discoideum AX4
Q552F9       119 TIL 121 Dictyostelium discoideum AX4
Q54UK5       120 IMI 122 Dictyostelium discoideum AX4
XP_015784257 118 ALV 120
EFX79779     128 TFI 130
XP_008185879 123 TLI 125
1_pfamImport 109 EML 111
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