Conserved Protein Domain Family
SLAIN

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pfam15301: SLAIN 
SLAIN motif-containing family
The SLAIN motif containing family is named after the presence of a SLAIN motif in SLAIN1. They are a family of microtubule plus-end tracking proteins.
Statistics
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PSSM-Id: 464627
Aligned: 29 rows
Threshold Bit Score: 342.462
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_040056678 142 WLYVSPKAKF-MGECLLSPLQWCRQVLDHPGPEVELAKMTLCHRLDQ---AKRWRG------RSSvrs-ysCIEGLSSLS 210
XP_023820526 152 WLYSSSKSTq-SSSDSLPPLEWCRKFLESPKSEVEAARSSLSLQLEE---VSRWRSslstpsSSSssprrpRVAGVSPIS 227
XP_005475531 144 WLYVSPKAKL-QGHSFLSPLQWCRQVLDHPGPEVELAKMTLCHRLDQ---------------APLp------SSGQSYLQ 201
NP_001005305 150 WLYVSPKAKL-FSHALLSPLQWCRHVLDNPKPEVELAKRSLCYKLDQ---AKRWRGvlsscvSSSvly--spLDGVSSLS 223
XP_003439990 162 WLYEAKLNS--PLQKALSPIVWCRQALDNPSPEMESAKRSLIHRLDLtmsANKRRSlygspyNQQsy--gsPYSTNAANS 237
XP_007257082 155 WLYEAKLNS--PLQKALSPIVWCRQALDNPSPDMESAKRSLLHRLDLtmsANKRRSlygntySPQvgy-gnQYSPNASNS 231
Q5RHE6       154 WLYEAKLNS--PLQKTLSPIVWCRQALDNPSPDMESAKRSLLHRLDLtmsGNKRRSlynssySPQvgy-gsPYSTNTANS 230 zebrafish
XP_005998610 133 WLYESPKKLt-PSQKNTSPLVWCRQVLDHPSPDIESSKRSLIHRLEQmmsASKRHSffsspyHTAsy--gsPYSPNAASS 209
XP_015200925  59 QLYETTKKSDsPLQKAVSPIAWCRQVLDHPTPDIESAKRSLIHRLDLtmsANKRRSfyg-----------spYSPTAGNS 127 spotted gar
XP_007251758 146 WLYVSPKAKM-FAQSPLSPQQWCRHVLDNPSPEVELAKRSLCYRLEQ---AKRWRGvlsgyaSSSlty-spvVDGLHSLS 220 Mexican tetra
XP_040056678 211 CPVLPYTKPAAPTEAPaplpscAQSFLQPLRaglsdrapt-------flsnatlhNVGRRH------AAISPQSSLDSEA 277
XP_023820526 228 SSPQPPDRPAPSYSSP------IHPLLHRTLspigkelspvsertptffphpasqGRNQRC------SAFSTRSSVDSDL 295
XP_005475531 202 PSLPLRASCSLADRTP------TFLSNSTLH------------------------NAGRRR------AAITPQSSLDSEV 245
NP_001005305 224 SCSKPFTKPALTEQTDpps----pnhQKPLTgrnclslters---ptflyhtatqSNSHRQ------RPLSPQSSIDSEL 290
XP_003439990 238 PYSSGFNSPS---STPsrvpivRQQLMPSNA------------------------IHQRNSaaernpPAVSPQSSVDSEL 290
XP_007257082 232 PYSSGFNSPSSTPSRVpi---vKQLVLPGNA------------------------GHQRSSdr--npPAVSPQSSVDSEL 282
Q5RHE6       231 PYSSGFNSPS---STPsrvpivKQLVLPGST------------------------GHQRGSndr-naQAVSPQSSVDSEL 282 zebrafish
XP_005998610 210 PYSSGFNSPS---STPvrlpvvKQLILPSST------------------------GHFRNStd--knPPISPQSSVDSEL 260
XP_015200925 128 PYSSGFNSPS---STParvpivKQLVLPGSS------------------------GHYRSPad--rnPPISPQSSVDSEL 178 spotted gar
XP_007251758 221 ACVKPLTKPTLTEQTVpsspssHCLLQQPLTgrssgglaers---psflyhtatyNYGRPH------ATVSPQSSTENDF 291 Mexican tetra
XP_040056678 278 GASeleDDSISMS--YKLQDMMDVEVMARLQEQSLRQDYASTSn--tATASRRRSSFSLHSLRR----SEMDLDEEDEEE 349
XP_023820526 296 GAPeleEDSLGLE--YKLQDLTDVQVMARLQEESLRQDYASTSc---VLANRRSQSFSFQLSSLgaglGLEAED----EE 366
XP_005475531 246 GVSeleDDSISMS--YKLQDMTDVEVMARLQEESLRQDYASTSatttATASRRSSSFSLHTLRRsq-mDLEEED-----E 317
NP_001005305 291 SASeleEDSVSMS--YKLQDMTDVEVMARLQEESLRQEYASTT----ATATRRSASFSIHTAARrsmrSEAEL------E 358
XP_003439990 291 STSemdEDSVGSSttYKLNDVTDVQILARMQEESLRQEYAATA-------SRRSSGSSCHSLRRst-fSDQELDAHSLED 362
XP_007257082 283 STSemeEDSVGSSttYKLNDVTDVQILARMQEESLRQDYAATA-------SRRSSGSSCQSLRRgt-lSDQELDAQSLED 354
Q5RHE6       283 STSemdEDSVGSSttYKLNDVTDVQILARMQEESLRQEYAATA-------SRRSSGSSCQSLRRgt-lSDQELDAQSLED 354 zebrafish
XP_005998610 261 STSemdEDSLGSG--YKLNDVTDVQILARMQEESLRQEYAATA-------SRRSSGSSCHSLRRgt-fSDQELDAHSLED 330
XP_015200925 179 STSemdEDSVGSG--YKLNDVTDVQILARMQEESLRQEYAATA-------SRRSSGSSCHSLRRgt-fSDQELDAHSLED 248 spotted gar
XP_007251758 292 STSeleDDSISMD--YKLQDMTDVQVMARLQEESLRQEYATTS----ATVARRSSSFSVHSGLRrpgrSVMDL------E 359 Mexican tetra
XP_040056678 350 EDEGYDqLppPQPRlFGAGSmqrgglphshtfsSIRDCRRG----------PIA-PQFs-lSGLSQy------SAPLSLT 411
XP_023820526 367 DEEEYGlLppPQPRlTClphs--------htfsSIRDWQKStsslctppstPSArPYLsagFAFQAqap-appAQSSLGL 437
XP_005475531 318 EDEGYDqLppPQPRlFRTGSmqrgslphshtfsSFRDCRRSs---------TTHqFSL---SGHSQy------SGPSSLI 379
NP_001005305 359 EEEEYDqLsvPQPRlFRTASmqrsts-htqnlsSMKDCRRS----------PSTpQYLn-sLSFQQlhv-annSSPTAEA 425
XP_003439990 363 DEEAVHpA--FHLPsNRFSPsprh-----spraSPRNSPRSr--------sPARsIDYs-hSRGSPqpiisrlQQPRHSL 426
XP_007257082 355 DEEEMLhPalYHPPvTRFSPsprp-----sprvSPRHSPRSr--------sPARsLEY---VRASPqpmisrlQQPRLSL 418
Q5RHE6       355 DEEAVHhS--YHTPvNRFSPsprh-----sprvSPRNSPRSr--------sPARsLEY---SRGSPqniisrlQQPRHSL 416 zebrafish
XP_005998610 331 EEECAPhT--LHPAiNRFSPsprhsp-rpsprhSPRNSPRSr--------sPARgLEY---SRVSPqpmisrlQQPRHSL 396
XP_015200925 249 DEEAAHhG--FHPPvSRFSPsprpsp-rpsprpSPRHSPRSr--------sPARsLEY---NRTSPqpiisrlQQPRLSL 314 spotted gar
XP_007251758 360 EEEEYDdLppPQPRlFRTGSmqrsls-hshnlsSPREARRS----------PSSpQYL---SSLsyqqq-fstpsPSSST 424 Mexican tetra
XP_040056678 412 M----EAHtTYRSSTDKLRRSMPNLLrAP---SMpsvpstpclasp---vnppshgpsslPTVSSLRSSQSFDSS----- 476
XP_023820526 438 GslyaAEQqDFRAGSDKLRRSMPNLVrAP---SMpips-------------------npcASPYMLRNSQSFDSS----- 490
XP_005475531 380 T----ETQtAYTNSTDKLRRSMPNLIrAP---SMpsvpsipclasp---vnppshgpsslPTMPSLRNSQSFDSS----- 444
NP_001005305 426 Q--------SYRANTDKLRRSMPNLLrAP---SIpsvinvpnvs-------aptghiattSSLSLLRNSQSFDSH----- 482
XP_003439990 427 QshghDLQtNVVKNEEKLRRSLPNLTrSSvaaAV--------------------------QAPEPVKNSRSCESNlqvpn 480
XP_007257082 419 QghahEPT-NAIKNEEKLRRSLPNLTrSS---SG--------------------------PAAEPVKNSRSCESNlqv-p 467
Q5RHE6       417 Qg--hDTQtNAIKNEEKLRRSLPNLTrSS---SG--------------------------STAEQVKNSRSCESNlqvpn 465 zebrafish
XP_005998610 397 QghttELQtNSVKNEEKLRRSLPNLSrTS---GI--------------------------QATESVKNSRSCDSNlqvsn 447
XP_015200925 315 QghgsDLQaNAVRNEEKLRRSLPNLSrTA---GV--------------------------QAAEPVKNSRSCESNlqvpn 365 spotted gar
XP_007251758 425 TsytaNEAhSYRTSTDKLRRSMPNLIrAP---SMlsvpsvpsvpsvvspaspapafpsfpSSSSSLRNSQSFDSS----- 496 Mexican tetra
XP_040056678 477 SGLARLQ---SS----------------------------IPSpgqLSQRvlSVGNFPTTPRHPLKATAYVSPTVQQ--G 523
XP_023820526 491 SALARLQ---SS----------------------------IPPpgkLQNRvqSVGNFSLLLRQPSKATAYVSPTIKGs-- 537
XP_005475531 445 SGLARLQ---SS----------------------------IPSpgqLSQRvqSVGSFPTTARHTLKATAYVSPTVQQgpT 493
NP_001005305 483 NALAKIQ---SA----------------------------IPSpgqLQQRvqSVGNFSMAARPPLKATAYVSPTIQS--- 528
XP_003439990 481 GGSPRHQs-qSA----------------------------IPSp--SKLRt-PATPSPLALRQPVKATSTPNS------- 521
XP_007257082 468 nGSPRHQtsqSAtaqqqrlsgparaspkpkerlqsptslrVPSs--SKLRt-PAAPSPLALRQPVKVVSNPSS------- 537
Q5RHE6       466 GGSPRHQs-qSA----------------------------MPSs--SKLRt-PAAPSPLALRQPMKVVSNHGS------- 506 zebrafish
XP_005998610 448 GGIPRLQlqsSA----------------------------IPSp--SKLRp-PAAPSPLALRQPVKALVNHGSASAG--- 493
XP_015200925 366 GGVPRLQq-qSAtphrytnmtrssp--kakqllqspaslrVPSp--SKLRa-PATPSPLALRQPIKAVATPSPt------ 433 spotted gar
XP_007251758 497 SGLARLQ---TA----------------------------IPSpgqLQQRvqSIGNFSTATRQPLKATAYVSPTIQG--- 542 Mexican tetra
XP_040056678 524 PPSMsASISLHSIPg-----------SaAAPQPLKPSSGLvqqppk---avcsqpAVTRSSLPRPASFV-----GMSGVP 584
XP_023820526 538 -----ASTSLQSLNg-----------S-GIPLLNKPAGGSvs-----------tpTTPRSSLPRPASFLc----TTSSAT 585
XP_005475531 494 STSLsTSASLNSISs-----------SaALPQPLKPSSSIsllpqalkptstnqsAVPRSSLPRPASFI-----GTSGVP 557
NP_001005305 529 SNTMaSSASLSCISs-----------S-SIPLPSKPSTP----------------SSSRSALPRPASFV-----GTNGAS 575
XP_003439990 522 ----------------------------ATSTPTRSLAP------------------PRSGLPRPSASTggggsGGIPLP 555
XP_007257082 538 ----------------------------GTSTPTRSLAP------------------PRSALPRPSGSAg----GGLPVP 567
Q5RHE6       507 ----------------------------GTTTPTRSMAP------------------TRSGLPRPSTNAg----GGLPVP 536 zebrafish
XP_005998610 494 -IPVpAHNSSPPPPaaaqpvgsstpvTvGSSSPSRSAGA-----------------GMRSGLPRPSAPAg----GGIPVP 551
XP_015200925 434 -----HSSGSPGPTpsp---------agGATTPTRSLGG-------------------RSGLPRPSTSAg----GGIPVP 476 spotted gar
XP_007251758 543 PTTMpSSVSLNSLSs-----------S-GIPLPSKPSTSS---------------STSRSALPRPASFI-----GTTGTA 590 Mexican tetra
XP_040056678 585 RaSKISQPTRSLLTPPKslaALTALRDGSWKDGCY 619
XP_023820526 586 R-SKVAQPTRSLLTPPKslsTFSALHNSRWRDGCY 619
XP_005475531 558 RpSKITQPTRSLLTPPKslaALSALRDGSWKDGCY 592
NP_001005305 576 R-SKIGQPVRSLLTPPKsvsALSALRDGSWRDGCY 609
XP_003439990 556 R-SKLAQPVRRSLPGPR---TYSG-GGENWREGCY 585
XP_007257082 568 R-SKLAQPVRRSLPAPR---SYSGIRDESWREGCY 598
Q5RHE6       537 R-SKLVQPVRRSLPAPR---TYSGIRDESWREGCY 567 zebrafish
XP_005998610 552 R-SKLAQPVRRSLPAPR---TYGNMKDDSWKDGCY 582
XP_015200925 477 R-SKLAQPVRRSLQAPR---TYGGIKDDSWKEGCY 507 spotted gar
XP_007251758 591 R-SKIAQPVRSLLTPPKsvaALSALRDSSWKDGCY 624 Mexican tetra
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