Conserved Protein Domain Family
RIC1

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pfam07064: RIC1 
RIC1
RIC1 has been identified in yeast as a Golgi protein involved in retrograde transport to the cis-Golgi network. It forms a heterodimer with Rgp1 and functions as a guanyl-nucleotide exchange factor.
Statistics
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PSSM-Id: 462078
Aligned: 68 rows
Threshold Bit Score: 127.323
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_003889645  469 LENSLWAWDGKQ----IVVWLDALALDGDnfPGreki-asgDKCQpLE-SRLTIPL------NFHPLSVLMDKGIF--IG 534 
ESN99121      721 LTNVLWLGCGANgtqsLKVWLPL--------QQredmgknkGFLS------KRIMLpf--aaDIYPLAMLFEAGII--LG 782 
XP_002114344  720 LTDALWLGCGADg---MKVWLPL--------YPsseg-kqpNFVA------KRIMLpf--klDVYPQAVLFEEAVI--LG 777 
Q4DY34        692 GINFLHLLGGEDdteiFPVVHEYAV-------------------SeFDaESIPVGLstyngcLFTAFSTREVIGSI--GG 750  Trypanosoma c...
CAM42881      998 LRPILYA---------HRIL------------------------------------------SLLLLEAMPSSLVPprVF 1026
Q4Q5K5       1000 LRPILYA---------HRIL------------------------------------------SLLLLAAMPSSPAShrVS 1028 Leishmania major
NP_001319814  630 VEEVSWLDYGHRg---MQVWYPSLGDDPFmqED---------FLQ-LD-PELEFDR------EVYPLGLLPNVGVV--VG 687 
XP_002967485  984 EEISWWAYGHQG----MQVWYPS---------------------SlSAdKTSQLDPeigfdrEVYPLALCPSAGVL--VG 1036
Q54WR7        719 IGNTLWAYGNSG----IQVWFPFSSE------------------EiLSnKNFNHNKslsfnnEVYPIGFLNELGVI--VG 774  Dictyostelium...
CCE40550      718 pvqfIYLFNGDQ----ILIYDVDEMVAKAcnKLhvn--qedAFESeDEsELVPIAIdt---dDILPLEIETDRNTInlIG 788 
XP_003889645  535 IEQK---------------TVIKKSLSFALFRIMTNTE-------------------------LFIHQVIKFYL-SRGKM 573 
ESN99121      783 AISEavcy--------stnGEETGQRQLPYLQLERTSQ-------------------------VYLHHILRQLL-RRNLG 828 
XP_002114344  778 ASNEtid----------lkSPGKSDVTFPFYSIDRTTQ-------------------------IYLHHILRQLL-RRNLD 821 
Q4DY34        751 TSST---------------VSLRISLKPLLYNFCVLTAltcmglpsletvnkktpsnvnpfplLMWNDHLLYWL------ 809  Trypanosoma c...
CAM42881     1027 STQDvsassfaartisrqsSRFEGGATCAVATASAISSshaaev-------------ddrvvtFMWDRNFFHWL------ 1087
Q4Q5K5       1029 NAPEasaslps--lissapPRLEGCATASAANASSTSScraaev-------------dgcvatFMWDRSLFYWL------ 1087 Leishmania major
NP_001319814  688 VSQR---------------MSFSASAEFPCFEPTPQAQ-------------------------TILHCLLRHLL-QRDKN 726 
XP_002967485 1037 VSQR---------------LSVSTCSEMPCFEPIPQAE-------------------------TILPCLLHHLL-QRNKQ 1075
Q54WR7        775 LSQG---------------ISYSSCSVYPNYEIHIKTH-------------------------PFLHSILKHLL-ERGGA 813  Dictyostelium...
CCE40550      789 LENL--------------------SSSYHHHDFVIKNKla---------------------hkLILNNFIEFDLiHRG-- 825 
XP_003889645  574 EEAVEFGAYYSKLIYFGH---SLEILLH-TVLEEEADFKINstgqnpsaqkpaspascstasnpatastlvadgnakntQ 649 
ESN99121      829 VHALEIARGCTDLVYFPH---VLELLIH-EVLEEEATSKEPipgemnacvwrtw------------------smslttas 886 
XP_002114344  822 VHAYEVARCCMSLPYFSH---ILELMLH-EVLEEEATASEPmp------------------------------------- 860 
Q4DY34        810 -------ESMRRNGTFIP---NADYFLH-TLISETILCSLD--------------------------------------H 840  Trypanosoma c...
CAM42881     1088 -------EYMRLNDTFSA---VFDYFLH-TALNDSPPAAVQ--------------------------------------G 1118
Q4Q5K5       1088 -------EHMRLNDTFTA---VLDYFLH-TALNESPPAAVP--------------------------------------G 1118 Leishmania major
NP_001319814  727 EEALLLAQLSAEKPHFSH---CLEWLLF-TVFDAEISRPNPnrnqi-----------------------------sgpgH 773 
XP_002967485 1076 DEALQLAKLSARNPHFSH---SLEWLLF-RVFDGAIFRQNPksn--------------------------------levS 1119
Q54WR7        814 EKAWNLSSKFYTIPHFTH---SLELLLH-EFISETDDLKKQfkiks----------------------------qstgqL 861  Dictyostelium...
CCE40550      826 ----DLESTFNKYKSFANfqfCLELLLFkLLVGGEQQHQQQ--------------------------------------Q 863 
XP_003889645  650 QERKILLPLVAEFLDHFK-ESLEVVVGCARKIDLKQWKNLFQIVG-KPRDLFEKSLNLGMLQVASSYL--LILnhyyldd 725 
ESN99121      887 qfldaLLPRVVAFVEEFP-EYLQTIAHCARKSDVAVWEYFFSVVG-NPADLFQDCLKSHKLTTAASYL--IIL------- 955 
XP_002114344  861 ---daLLPRIVAFIQEFP-SYYHIVVHCARKTEFDLWDYLFAAVG-NPKNMFEECLASGDLETATSCL--IIL------- 926 
Q4DY34        841 DSRLAAVQATVSLLRRYS-EFYSVVVSCMRMLDVSQWRKLLDVLG-SPLEFFRECIENRRFEESAQLLrvIMLdgnf--- 915  Trypanosoma c...
CAM42881     1119 LGRRSAVRATIALLRNYP-EFYAIVVGCMRKMDFTRWRLVLDFLG-TPTDLFHECVAHYCYAEAVHLIrvIMMgtykpva 1196
Q4Q5K5       1119 LGRYSAVRAAISLLRNYP-EFYAIVVGCVRKIDFARWHLVMDFLG-TPTDLFHECVAHHCYAEAVHLVrvIMMgtykpaa 1196 Leishmania major
NP_001319814  774 LKKLSLLRKACDLIKNFP-EYYDVVVNVARKTDARHWADLFSAAG-ISTTLFEDCFQRRWYRTAACYI--LVI------- 842 
XP_002967485 1120 TKKTSLLEQVCDLIRNFP-EYPDVVVSVARKTDGRHWPLLFAAAG-DSTKLFEECFERKSYHTATCYI--LVI------- 1188
Q54WR7        862 SPAGLKLEYVINFLKKFP-QFPEVAMRATRKIDASLWRGLYTIIG-DPFILYQKCLSNGKIEIAASYL--KIL------- 930  Dictyostelium...
CCE40550      864 QSSNLTLKRLFQLI-EFTeSPESIYINCLRKIEVAYWNKFFNVLNtTPVKFMDRLIKLDNVELCYHYL--IVYlnykkeg 940 
XP_003889645  726 dsffdssikifnqdcpvQNLKPNq---lEEDHysieiiySDTVRLFKIGIEVKNWALCKELMRFLFSLDHTGK 795 
ESN99121      956 -----------------QNLEKP-----NQAR-------QHAISLLDAALNESSWDLARDLVRYLSVIDLTcd 999 
XP_002114344  927 -----------------QNLEPS-----DVSR-------LHATLLLDTALAKHKWELAQDVVRFLRAAGPCSD 970 
Q4DY34        916 -------------pddgASVKSL-----EATM-------LCAVHLFVLALWRRNVPLVHDLLRFMALLHTELV 963  Trypanosoma cruzi
CAM42881     1197 tlsvnrvaelgssgcaaSDITPL-----QQAS-------QCAVELFVLSVENGNYTAAYDIMRFMARLEEEIG 1257
Q4Q5K5       1197 tlpvdrtaelgsggrsgSDVTRL-----QQAS-------QCAVELFVLSVENGSYTAAYDIMRFMALLEEEIG 1257 Leishmania major
NP_001319814  843 -----------------AKLEGV-----AVSQ-------YCALRLLQATLDESLYDLAGELVRFLLRSGRDIE 886 
XP_002967485 1189 -----------------AKLEGP-----SVSQ-------RGALRLLQATLDEFMYELAGELVQFLLRIGREYE 1232
Q54WR7        931 -----------------QHLNTN-----SNTSfqddisrKCAIELLEISLDFDNIDLVGDLIRFLHTSDEDNA 981  Dictyostelium discoi...
CCE40550      941 epgdnenngkvedtyesGTVSHAnggegAAPDqlsgddkQIILQIIKMLAESEKWDWCFELCRFIKILEPSGQ 1013
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