1E0A,1CEE


Conserved Protein Domain Family
CRIB
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cd00132: CRIB 
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PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the Ras-Rac pathway. CRIB-containing effector proteins are functionally diverse and include serine/threonine kinases, tyrosine kinases, actin-binding proteins, and adapter molecules.
Links
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Statistics
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PSSM-Id: 238077
Aligned: 17 rows
Threshold Bit Score: 35.1069
Created: 1-Nov-2000
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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GTPase
Conserved site includes 7 residues -Click on image for an interactive view with Cn3D
Feature 1:GTPase interaction site [polypeptide binding site]
Evidence:
  • Comment:contains the CRIB-motif (I-S-x-P-x-x-F-X-H-x-x-H-x-G-x-D) described in the literature
  • Comment:interacts with Cdc42 switch I and II in the presence of GMPPCP and Mg2+
  • Structure:1E0A; Cdc42-PAK complex
  • Structure:1CEE; Cdc42-WASP complex
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1        #  #   # #  #                     #   #         
1E0A_B       1 XSISLPS-DFEHTIHVGFDAv-tGEFT--GMPe--QWARLLQt--sNITK 42   Norway rat
Q00587      36 DMISHPLgDFRHTMHVGRGGd-vFGDT--SFLs-nHGGSSGSt---HRSP 78   human
Q03607     129 DSISLPR-NFTHIAHVGWNGasvLFDKkmTDDp--TVRKICDa---AAEA 172  Caenorhabditis elegans
P38785     124 SSISTPF-DFHHISHANGKRednPLES--HEEk-hDVESLVKf---TSLA 166  baker's yeast
AAF47163  1544 KMISAPT-NFNHISHMGPGD---GIQNq-RLL---DLPTTLEtadqACSP 1585 fruit fly
T25808    1498 IQISTPS-DFMHIVHMGPAPv-mELQQ--NFI---DLQSNHSh---TSSD 1537 Caenorhabditis elegans
NP_064625   27 SMIGEPT-NFVHTAHVGSGD---LFSGm-NSVs--SIQNQMQs--kGGYG 67   human
Q06648     132 KGISTPF-DFQHISHADTRN---GFQDe-QLQepsSLSTEIKd---DYTS 173  baker's yeast
Q9I7F7     486 EMISKPQnDFKHTGHVGIDG---ATFG--DIA---FLGSSQNy--nHVPK 525  fruit fly
NP_914302   25 MEIGWPT-DVRHVAHVTFDRf--HGFQ--GLPv--ELQPEVAg--nAPSA 65   Japanese rice

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