Conserved Protein Domain Family
ADNP_N

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pfam19627: ADNP_N 
Activity-dependent neuroprotector homeobox protein N-terminal
This entry represent the N-terminal domain of Activity-dependent neuroprotector homeobox protein (ADNP, also known as Activity- dependent neuroprotective protein), which contains zinc finger motifs. It is involved in transcriptional regulation and it is vital for mammalian brain formation. In humans, de novo mutations result in a syndromic form of autism-like spectrum disorder (ASD), including cognitive and motor deficits, the ADNP syndrome. This protein is also related to autophagy and the pathophysiology of schizophrenia.
Statistics
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PSSM-Id: 466132
Aligned: 10 rows
Threshold Bit Score: 1195.82
Created: 27-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_018593304    1 MFQLPVNNLGSLRKARKNVKKVLSDIGLEYCKDHIDDFKDFVP--NDFYVKNTSWEDVCMWDPSLTKPQEYRSKPFCCSG 78  
XP_006639601    1 MFQLPVNNLGSLRKARKTVKKVLSDIGLEYCKEHLEDFKEFGP--NDFYVKNTSWEDVGLWDPSSTKPQDYRSKPFCCSG 78  
XP_018093662    1 MFQLPVNNLGSLRKARKNVKKILGDIGLEYCKEHVDEFKQFEP--NDFYVKNTSWDDVGLWDPSLTKNQDYRTKQFCCSQ 78  
OPJ82687      143 MFQLPVNNLGSLRKARKTVKKILSDIGLEYCKEHIEDFKQFEP--NDFYLKNTTWEDVGLWDPSLTKNQDYRTKPFCCSA 220 
NP_001073484    1 MFQLPVNNLTRLRKARKKVKRLLSDIGLDYCKEHVEDYKDVDP--DDSDDSNESHLDLCTWDPTWTKSQDYRTKQFCCSD 78  
KPP62677       37 MFQSPVHNLYSIRKARKNVKLILGDIGLEFCKDYVEDFKEFCP--NEFYIKNTSWDD------------EYRSKPFWCSG 102 
CDQ87493        1 MFQLPVNNLGSLRKARRNVKRVLGDIGLEFCKDHIEDYKDYVPdnNEFYIKHTTWDDVCVWDPSLTKSQDYRSKPFCCSG 80  
XP_007249908    1 MFQLPVNNLGSLRKARKNVKKVLGDIGLEFCKEHVDDFKDFVP--NEFYIKNTTWDDVCMYDPSHTKNQDYRSKPFCCSG 78   Mexican tetra
XP_020368510    1 MYQLPVNNLANLRKARKTVKKILTDIGLDYCKDHIEDFKQFEP--NDFYLKNTTWDDVSLWDPSSTKLQDYRTKPFCCSA 78   whale shark
XP_014347726    1 MFQLPVNNLGSIRKARKTVKKILSDIGLEYCKEHIEDFRNLSN--NSFFL------NSNNFNFYL--FQDYRTKPFCCSA 70   coelacanth
XP_018593304   79 CPFSSKFFSAYK---SHFRNVHSEDFESRILLNCPYCTYNGNKKTLETHIKLFHMPNNv----vRQGMGSgPAGLKDAGR 151 
XP_006639601   79 CPFSSKFFSAYK---SHFRNVHSEDFESRILLNCPYCTYNGNKKTLETHIKLFHVPQTnh---lVRGSGTlKDTSRLDSN 152 
XP_018093662   79 CPFSSKFFSAYK---SHFRNVHNEDFENRILLNCPYCTYNGDRKTLEMHIKVFHAPNA------PAQSPG-L--FKDKSK 146 
OPJ82687      221 CPFSSKFFSAYK---SHFRNVHSEDFENRILLNCPYCTFNADKKTLETHIKIFHAPNA------NTPSGG-ISTFKDKNK 290 
NP_001073484   79 CPFASKYFSAYK---NHFRNVHREDFESRILLNCSYCTYSGNKRTLETHVRLFHMPHNvmrqgvVGPHGA-PVGAKDGMR 154 
KPP62677      103 CSFSSKFFSAYK---SHFRN------------------------------------------------------------ 119 
CDQ87493       81 CPFSSKFFSAYKtykSHFRNVHSEDSESRILLNCPYCTYNGNKKTLETHIKLFHMPNNv----vRQGPGGmQGAVGGLKD 156 
XP_007249908   79 CPFSSKFFSAYK---SHFRNVHSEDFENRILLNCPYCTYNGNKRTLETHIRLFHMPNNv----aRQSPGG--LQGTAAGL 149  Mexican tetra
XP_020368510   79 CPFASKFFSAYK---SHFRNVHSEDFENKILINCPYCPYNADRKTLETHIKIFHVPLW------KVPSGG-KNAHNEKSK 148  whale shark
XP_014347726   71 CPFSSKFFSAYK---SHFRNVHSEDFENRILLNCPYCTFNGDKKTLEAHIKIFHTSSV------NIPSGG-AHLYKDKNK 140  coelacanth
XP_018593304  152 LDSsHklKPMDSMEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYMAKPGDKS--VNGAV---GGNS----RDDT- 221 
XP_006639601  153 HKP-K--QAADSVEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYIVKTGDKS--LNGAVn--PSAT----ARDDg 221 
XP_018093662  147 LES-LkpKQGDSVEQAVYYCKKCTYRDPLYEVVRKHIYREHFQHVAAPYVAKASDKS--LNGTLp-lGSIQ----RDDGn 218 
OPJ82687      291 HES-LkpKQADSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVAAPYIAKGGEKS--LNGAVp-lSSST----REEGs 362 
NP_001073484  155 VDKp---MLGDRKELPVYYCKKCTYRDRLYNVVRRHIYREHFQHVATPYLGKNSEKQ--VNSGE----AQA----NSHG- 220 
KPP62677      120 ---------------------KCTYRDPLYNVVRKHIYREHFQHVAAPYVSKAAEKC--VNGGTaptPTNP----RDADa 172 
CDQ87493      157 GMQ-LgkRPGESIEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAKPYLVKLEEKTt-PNGSAadrSSNA----NANSn 230 
XP_007249908  150 KDGvRldKVRESVEQAVYYCKKCTYRDPLYNVVRKHIYREHFQHVAAPYMVKPGEKTatPNGSAa--GSDTtdsnSTAGs 227  Mexican tetra
XP_020368510  149 QDGnLklKHADSVEQAVYYCKKCTYRDPLYDVVRKHIYREHFQHVAAPYVARTGDKS--VNGTFs--APNG----RDDGt 220  whale shark
XP_014347726  141 QES-LkpRQTDSVEQAVYYCKKCTYRDPLYEIVRKHIYREHFQHVASPYIAKPGEKS--LNGAVa-lSAST----RDDGs 212  coelacanth
XP_018593304  222 ---IHCKRCLFVPRTYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMQLSPKPQ-EKGILGVTQKGTLVT-TSIR 296 
XP_006639601  222 --nIHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLLSPKTQ-DKNLLGLSQKGASVP-STVR 297 
XP_018093662  219 ---IHCKRCLFMPKTYEALVRHVIEDHERIGYQVTGMIGHTNVVVPRSKPLMLIAPKPQ-DKKTMGITQRLGTMSpGNIR 294 
OPJ82687      363 ---IHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLITPKPQ-DKKPMGLPQRMGALSpGSVR 438 
NP_001073484  221 ---IHCKSCHFTPRSYEALVQHVIEFHERIGHQVTAMIGHTNVIVPR----LQTNPIQR------GVPITSGV------- 280 
KPP62677      173 ---IHCKRCLFIPRTYEALVQHVIEDHERIGYQVTAMIGHTSVVVSRPQPAVLVSPKLQ-DKSILGVTAKGSLVTsGV-H 247 
CDQ87493      231 --tIHCKRCLFLPRTYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKPVILVTTTVG------------GV------R 290 
XP_007249908  228 staIHCKRCLFVPRTYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRAKSGLMVPPKGQgEKNVIGVTSKGSLVT-GGVR 306  Mexican tetra
XP_020368510  221 ---VHCKRCLFIPKTYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPH-DKPSLAAANYQSI------K 290  whale shark
XP_014347726  213 ---IHCKRCLFMPKSYEALVQHVIEDHERIGYQVTAMIGHTNVVVPRSKPLMLIAPKPQ-EKKSLGVPQRVGNIPpGNVR 288  coelacanth
XP_018593304  297 SLSAQQL--NRLVIPk-------aGLLSGTQLKQGPYTLKTg-SPQAYSlsGQQVRITLPGNAQVSVPQ----QSQTMKQ 362 
XP_006639601  298 SLSSQPMmsSRLAIPkpgl--nsaAMLSNVHIKQNPYGLKNi-PQGYSL--GQHMRIPMPGNAQVSVPQ----QSHTVKQ 368 
XP_018093662  295 TLPSQQMv-NRLSIPkps---mnsNMMSNVHLQQNSYGVKN--MPSGYTv-GQSMRLGMGGNSPVSLQQ----QSPSMKQ 363 
OPJ82687      439 SLSSQQMm-NRLTIPkptl--nsagMMSNVHLQQNNYGVKS--VPPSYVg-QPGGRLSLSGNAAVSIPQ----QSQSMKQ 508 
NP_001073484  281 RPQTPQM--NRFSMP-------------------KVVGLPV----------GNHFKQSLAGNS---VP------GQPVRV 320 
KPP62677      248 AINAQQF--NRLSQSk-------aGMLSSVPLKQGQFGLKGsaTQVFSVa-NPQVRVTLHSSQ-----Q----GPLTIRA 308 
CDQ87493      291 SVSTQNL--SRIVIPksgl--sstgLLSGVHLKQGAFGLKSgtTQSFSIg-GQQVRITLPGNAKVSVPQ----HSQAAKQ 361 
XP_007249908  307 PLSAQQL--SRIIIPkggl--nsagVLSGVHLKPGGLGLKA----------GTSQSVSIGGQvRITLPgsshlsSQTGRH 372  Mexican tetra
XP_020368510  291 TSMHQGM--GRVSMSknaq-nsavNLMSSTGRLPPKYAISS--MAHNYPl-GQQLRLPLPGGLPVSLQQ----RSQTVKQ 360  whale shark
XP_014347726  289 SLPSQQMv-NRLSIPkpalnsagvNLMSNVHLQQNSFGLKT--VPPGYGm-GQPVRLALAGNSQVPVPQ----QSQTLKQ 360  coelacanth
XP_018593304  363 QLPGGNMRISGTLgSVEGR------SFQ---SGTST-----SSSTLKSIPLSSRVqaa-atAVGSVAAKk-GSTSILG-- 424 
XP_006639601  369 HIPGGNVRNSTAGaSESRSqapsrlSFQsgnSSSSNla-ssTAKPSQVPARAQSA------TAVAAATKt-VNSTNAG-- 438 
XP_018093662  364 LLPGGNGRSYTLGsDQRSQaql-rySLP---SGNSGl----STGQLKTASITPAHaa--srALAQASSK--TPTSAAAaa 431 
OPJ82687      509 FS--GNGRPYTLGgEQRSQasa-rfSLQ---SANSSs---lSSAQLKQTSLSQSQaa--srVLGQSGSK--S-VAATGps 574 
NP_001073484  321 TLPDKAFVSSAVShSHSGKhlg-gfGVHgaaHLNAQsa--sFSPSLKSLPLSSSVhaa-taTLTSLQAK---KASANAl- 392 
KPP62677      309 NLSSGNNTR---GlAVTGQvpa-rlSIQ---AGSSSsp-mvASSVLKPVPLSSQVqaaattVTSINPGK----KGGSGsl 376 
CDQ87493      362 NLTGGLRSPIVVSsSSSTLn----sRVQ----AAAA-------------TVASVT------AKGKGVNS------VLG-- 406 
XP_007249908  373 HL--------------SAS------HLR---NAVSAs---tSASLLKIPPLNSRVqa---aaVTTGPPK--KGASALG-- 419  Mexican tetra
XP_020368510  361 LISSGNGRQYGVSeQRRPSqm--qyNVQ---SGGLTgnsasSQMSMKQSQYSISQaq---rMQGLPTSAvkSLTSSAGls 432  whale shark
XP_014347726  361 LLPSGNGRPFSVG-DQRPQppn-rfALQ---SGNSAa---nLSGQLKPTQLSAPQtt--trIPVQSSVK--SSATASMvp 428  coelacanth
XP_018593304  425 ----------TSYTQKWKICTICNELFPENVYSAHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLI 494 
XP_006639601  439 ----------TSYTQKWKICTICNELFPENVYSAHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLI 508 
XP_018093662  432 aa-----ansNSSTQKWKICTICNELFPENVYSAHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLI 506 
OPJ82687      575 s-------vnTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLI 647 
NP_001073484  393 ---------nTSQTQKWKICTICNELFPESAYSAHFEKEHQAEKVRAMAKYIMKIHNFTSKCLYCNRYLPSDSLLNHMLV 463 
KPP62677      377 --------lgTSYTQKWKICTICNELFPENVYSAHFEKEHKAEKVRAVANYIMKIHNFTSKCLHCNRYLPSDTLLNHMLI 448 
CDQ87493      407 ----------TSYTQKWKICTICNELFPENVYSSHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLI 476 
XP_007249908  420 ----------TSYTQKWKICTICNELFPENVYSSHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPSDTLLNHMLI 489  Mexican tetra
XP_020368510  433 nsapqssalaGSAAQKWKICTMCNELFPESVYSIHFEKEHKAEKIQAVANYIQKINSFTSKCLYCNRYLPSETLLNHMLI 512  whale shark
XP_014347726  429 p-------snTSSTQKWKICTICNELFPENVYSVHFEKEHKAEKVPAVANYIMKIHNFTSKCLYCNRYLPTDTLLNHMLI 501  coelacanth
XP_018593304  495 HGLSCPYCRSTFNDVEKMVTHMRLVHPDEVVGPRTDSPLTFDLTLQQGNPKNIQLIVTTYNMRDAPEESVAF---HAQN- 570 
XP_006639601  509 HGLCCPHCRATFNDVEKMVAHMRLIHPDEVVGPRTDSPLTFDLTLQQSNPKNIQLIVTTYNMRDAPEESVAF---HAQN- 584 
XP_018093662  507 HGLSCPYCRSTFNDVEKMAAHMRMVHANEEMAPKTDSTLTFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAY---HAQNp 583 
OPJ82687      648 HGLSCPYCRSTFNDVEKMAAHMRMVHVDEEMGPKTDSTLTFDLTLQQGSHTNIHLLVTTYNLRDAPAESVAY---HAQN- 723 
NP_001073484  464 HGLSCPHCHSTFHEVEKIVAHNRLAHPNEQGDQPTGSPLTFDLTLQQGNLKNVQLLVTTYNMKETPEAAAAA---AAANq 540 
KPP62677      449 HGLSCPHCRATFNDVEKMVVHTRMVHPDETVGPRNDSPLTFDLTLQNSNPKNVQLIVTTYNMRDAPEESVAF---HAQN- 524 
CDQ87493      477 HGLSCPHCRATFNDVEKMVSHMRQSHPDETVGPRTDSPLTFDLTLQQGNPKNVQLIVTTYNMRDAPQESVAL---HAQS- 552 
XP_007249908  490 HGLSCPYCRANFNDVEKMVAHMRASHPNESVGVRTDSPLTFDLTLQQGNPKNVQLIVTTYNMRDAPEESVAF---HAQNn 566  Mexican tetra
XP_020368510  513 HGLSCPYCRSTFNDVEKMAEHVRILHIDEEVGPKTESTLTFDLSTQKGSRSNIQLLVTTYSISESASMENTNyrpQSQNl 592  whale shark
XP_014347726  502 HGLSCPYCRSTFNDVEKMAAHMRMVHIDEEMGPKTDSTLTFDLTLQQGSRTNIHLLVTTYNMRDAPAESVAY---HAQN- 577  coelacanth
XP_018593304  571 ---NSSs---aQCKKSLPKMPDSl---D---VPIKSAPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 638 
XP_006639601  585 ---NNAs---vQCKKMPPKIPES----Hd--APVKSAPQTAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 652 
XP_018093662  584 --nASP-----VPQKTTPKTVEKq---PeqpAPIKNSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 653 
OPJ82687      724 ---TPP-----VPPKPQPKIQEKs---D---VPVKSSPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 789 
NP_001073484  541 lsqNSA-----MPKPVKVSVRQPdtqsD---SLVRNMSQSPVSQKKEVGKTLCPLCFTILKGPISDALAHHLRDSHQVLQ 612 
KPP62677      525 ---NSTtv-vsQAAKVPPKVAEVq--sN---MLTKAMPQAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 595 
CDQ87493      553 ---ASS----------STQTGKR---------------TAAVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 604 
XP_007249908  567 --aSPVpqtnkPATSHSPKIHSPeappEa--IRTKVSPQTAVPYKRDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 642  Mexican tetra
XP_020368510  593 t-fRKPe---gQLQQPKPPVKSKik-pD-----LNSIPQTQIPYKNDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 662  whale shark
XP_014347726  578 ---TPP-----PPPKPQPKVQEKt---E---VPVKTSTQTSVPYKKDVGKTLCPLCFSILKGPISDALAHHLRERHQVIQ 643  coelacanth
XP_018593304  639 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQD-KLGASLKVAQSSGVASLKRDIEH--SDPVFQK 715 
XP_006639601  653 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQD-KGTATIRGTQSPGAAPLKRELEH--SDPGLLK 729 
XP_018093662  654 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQD-KSIPPPKINPGPLLTTMKRTNDY--VEMALAK 730 
OPJ82687      790 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQD-KGTSASRLG-APAVAPVKRTYEH--MEFSLMK 865 
NP_001073484  613 TLHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVCQTPKG----SKPITTGLRSPGAGSLKRELVT--PDPSDPK 686 
KPP62677      596 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKAQNGPD------SRPALAG---PTKRELEP--ADSYPAK 664 
CDQ87493      605 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQDsRPAPSPRVSQAQGISLKRAGFEN--CDPNDPK 682 
XP_007249908  643 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKTQNGQEsKPSHTTRVVKAQGSSLKRTGFNH--NEETDPK 720  Mexican tetra
XP_020368510  663 TIHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKAQNGQD-RSLAHAKATHSPSAMPMKREYEYeyGDFALMK 741  whale shark
XP_014347726  644 TVHPVEKKLTYKCIHCLGVYTSNMTASTITLHLVHCRGVGKAQNGQD-RAATQPRVTQTSALPPVKRSYDY--VELALMK 720  coelacanth
XP_018593304  716 KRKL----DSEHCPtSS---VEKFDEPVVLAL 740 
XP_006639601  730 KRKL----DRDSYP-STf--VEKPEEPVVLAL 754 
XP_018093662  731 RRRMd---DDPDAP-LIi--DDKPEEPVVLAL 756 
OPJ82687      866 KRKMd---DD-DSP-SAf--EERPEEPVILAL 890 
NP_001073484  687 RRKMv--dQSRFYP-TGf--AEKPEEPIVLAL 713 
KPP62677      665 RLKLq---ETERCP-SPv-tGDSLEEPVALAL 691 
CDQ87493      683 RRKLp--pGEPESP-AAf--VENPDDPVNLIL 709 
XP_007249908  721 KRKFgpgnQTH--L-SAp--VEPKEEPVVLAL 747  Mexican tetra
XP_020368510  742 KRKLd---GEESVQ-SFtlgEDKPEEPVVLAI 769  whale shark
XP_014347726  721 KRKLe---EENDPS-STi--EEKPEEPVVLAL 746  coelacanth
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