6P9E,6HPI,4IZE


Conserved Protein Domain Family
beta-trefoil_IL36

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cd23300: beta-trefoil_IL36 
beta-trefoil domain found in the family of interleukin-36 (IL-36) and similar proteins
The IL-36 family includes three members, IL-36 alpha (also called FIL1 epsilon, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 6, or IL-1F6), IL-36 beta (also called FIL1 eta, or interleukin-1 eta, or IL-1 eta, or interleukin-1 family member 8, or IL-1F8, or interleukin-1 homolog 2, or IL-1H2), and IL-36 gamma (also called IL-1-related protein 2, or IL-1RP2, or interleukin-1 epsilon, or IL-1 epsilon, or interleukin-1 family member 9, or IL-1F9, or interleukin-1 homolog 1, or IL-1H1). They act as cytokines that bind to and signals through the IL1RL2/IL-36R receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells linked to a pro-inflammatory response. They are parts of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; like the IL-1 system with which they share the co-receptor IL1RAP. They may be involved in skin inflammatory response by acting on keratinocytes, dendritic cells, and indirectly on T-cells to drive tissue infiltration, cell maturation and cell proliferation. Members in this family contain a beta-trefoil domain, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 466782
Aligned: 19 rows
Threshold Bit Score: 210.608
Created: 5-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
 
ligand binding
Conserved site includes 12 residues -Click on image for an interactive view with Cn3D
Feature 1:ligand binding site [chemical binding site]
Evidence:
  • Structure:6P9E; Homo sapiens IL-36gamma complexed to A-552, contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1          #                                   # #            # #                        
6P9E_A         4 KPITGTINDlNQQVWTLQG-QNLVAVPrsdsvTPVTVAVITCKypealeqgrGDPIYLGIQn--pEMCLYCEKVGeQPTL 80  human
ELK14854       3 KPGLYRIRDpLQMVWVLQG-NTLVAVPansnvKPVTMCSVPCQhmt---sgeNSHIYLGVEs--sGLCLFCMDIQgQPTL 76  black flying fox
NP_775270      8 APKSYAIRDsRQMVWVLSG-NSLIAAPlsrsiKPVTLHLIACRdtefsdkekGNMVYLGIKg--kDLCLFCAEIQgKPTL 84 
XP_027701526  16 QPNFRGIRDiHQQVLVLQE-KTLIAVPqdvdvHPISMMSIPCRdqsl-ekdkGNPIYLGIAe--tELCLCCEESGeQPIL 91  common wombat
XP_027701529  13 HPYVFRIQDfNQQVLALQN-NTLIATPhsdhvTPVILESMPCRakeylvrdkGTAIYLGIQk--kELCLFCEESGgQPTL 89  common wombat
XP_016057249   9 EPVCHSIRDsQQMVWSLNEnLSLIAVYstnsvTPVTICSVPCTdpkvhdekkGIPIYMGIKg--kDLCLFCAEAGgKPTL 86  Miniopterus nat...
XP_007477645  36 KVPIGEIHDvQQQVWILKG-ETLIAAPhekgvNPVSLKVLPCRddsl-pkdkGDPIYLGINe--tDFCLCCEVSGgQPQL 111 gray short-tail...
XP_023350992  13 IVSIIHLKDtNQQVLILQD-NILIASPhsdyvTPVTFASLPCRdienlaidkGSPIYLGIDg--kELCLCCEESEgEPTL 89  Tasmanian devil
XP_007477640  29 HPSPRKIRDvHQHVFVLQE-RTLIAVPedenvTPIILETVSILdesl-ekgkGNALYLGIGeqnpHLCLCCVADEgQPTL 106 gray short-tail...
XP_007477638  14 QPRQRIVHDmEQQVWVLQG-KILIGTPlnenvIPEKILTISCRddayvnkdkGNAIYMGVKs--nGLALSCVDSGgQATL 90  gray short-tail...
Feature 1                               # #     #                                   ### #
6P9E_A        81 QLKEQKImDLYGQPepvKPFLFYRAKt-GRTSTLESVaFPDWFIASSkr-dQPIILTSELGksYNTAFELNI 150 human
ELK14854      77 QLKEKNImDLYEDPhvqNPFLFLRAMe-GATSTFESVaYPSWFIATAsvggQPVTLTKDRGrdYNTNFYFEP 147 black flying fox
NP_775270     85 QLKEKNImDLYVEKkaqKPFLFFHNKe-GSTSVFQSVsYPGWFIATSttsgQPIFLTKERGitNNTNFYLDS 155
XP_027701526  92 KLKERDImELYRNQkaeKSFVFYRNAt-GNISTFESAaYPGWFICSSvekgKPITITKDVGk-NNIAFYFDP 161 common wombat
XP_027701529  90 KLQSNNVmALYSSEnaqKPFVFYQNQa-DSTSTFESAaYPGWFMCTSnekdRPITMTQNGGtkYNTVFSLTS 160 common wombat
XP_016057249  87 QLKETNVmDLYKSDkaqEPFLFLRNIe-GSTSSFQSFtYPGWFIATAseegQPVTLTNERGktYNTNFYFDP 157 Miniopterus natalensis
XP_007477645 112 QLVKEDImKLYNNPeavKAFVFYQNRt-GSTSTLESAaYPDWFISSSdk-dQPIILTHNTKsqYNTAFYLDI 181 gray short-tailed opossum
XP_023350992  90 KLKEKNVwKLYQSKdaeKPFVFYQDQn-GSMSSLESAaYPGWFICTSsernRPLRMTQQKEpnCNTSFYLSQ 160 Tasmanian devil
XP_007477640 107 KLEEKDImDLPRTEnavKSYVFYHNQssNNISTFESAaFPGWFICSSeeqrKPINITNDVGk-NNISFFLDF 177 gray short-tailed opossum
XP_007477638  91 KLEKKNItDLYNLKkaeKPFVFYLKEt-GSTATFESAaYPDCFICSSl--gGPITLTKGSGkeKNTHFHLED 159 gray short-tailed opossum

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