Conserved Protein Domain Family
BRI3
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pfam10164: BRI3 
Brain protein I3
This is a highly conserved family of proteins which contains three pairs of cysteine residues within a length of 42 amino acids and is rich in proline residues towards the N-terminus. It includes a membrane protein that has been found to be highly expressed in the mouse brain and consequently, several members have been assigned as brain protein I3 (Bri3). Their function is unknown but they appear to play a role in TNF-induced cell death.
Links
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Statistics
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PSSM-Id: 431102
Aligned: 11 rows
Threshold Bit Score: 111.923
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
XP_006000844  28 SYGTIPAAQ-------VGFQPPPPYPYPAapgfsggpp-pasvqppysSTYTIIQQPa-TTSVVVVG------GCPACRV 92 
XP_003229961  35 NYGAIPHAPppyapgyVVPPIPPPHSFPN-------------------TTYTIIQQPlpTTSVVVVG------GCPACRV 89 
P28662        29 GYGAIPTAPppppypyLVTGIPTshpr-----------------vyniHSRTVTRYP--ANSIVVVG------GCPVCRV 83  house mouse
XP_009026329  67 NYSSTTTTTnqqttvyTSQPVPPfhqqq----------------qrvlVTAPIV--Pa-DQSIIIVG------GCPVCRI 121
EDV90424      18 mqATMPSAPdtrlitgVHHGAPTapnnmas------------ygafetTPVSIVVHPsqPAQIFLIN------ACPSCRI 79 
XP_002431287  17 PYSAYPTEVqqygfqtPVTQQPNytpq-----------------qyipTPTFIQPSPv-NQTVVIMG------GCPSCRT 72 
XP_002127472  10 AYGHQP----------VYNQQPMPMQQPMpmqqpvinvv-------qqqqqqqqqQP----SVVVVGgqggglGCRRCGA 68 
XP_001851394  58 NYGSMQSS---------GVKVPLQPGVVVplgqatg------agggpsTTATTVVIP---QEIIVVG------GCPVCRI 113
XP_014327891  33 GYGAIPAA------------APPPYHYPDgpgyppaqmgpavsqqpytSTYAII-QP----SVVVVG------GCPACRV 89 
XP_003964604  30 GYGSIPPP------------APPPYAYPDpqgypsaqtvpavsqqpyhGTYAII-QP----SVVVVG------GCPACRV 86 
XP_004071519  31 GYGAIPAA------------GPPPYQFPDgrafpsaqmgpavsqqpcvGTYAII-QP----SVVVVG------GCPACRV 87 

XP_006000844  93 GVLEDDFTCLGILCAIVFFPIGILFCLALRQRRCPNCGATF 133
XP_003229961  90 GVLEDTFTCLGVLCAIAFFPVGILFCLALRQRRCPNCGATF 130
P28662        84 GVLEYCFTCLGIFLAIVLFPFGFLCCFALRKRRCPNCGAVF 124 house mouse
XP_009026329 122 GVLQDDFTCLGVCCAIVFFPMGLLFCLLFRERRCNNCGAVF 162
EDV90424      80 GYLEDTFSPLGLCCAIFFFPLGILCCLAMREKRCSNCGATF 120
XP_002431287  73 GTLESDFTCCGILCAIFCFPIGILCCLCMKQKKCNQCGATF 113
XP_002127472  69 TGLSDSFTCCGICLAIFFFPIGLICCFCMREKKCSGCGApy 109
XP_001851394 114 GMLEDDFTCCGIFCAIFFFPVGILCCLAMKNRRCSNCGAQF 154
XP_014327891  90 GVLEDDFTCLGILCAIFFFPLGILFCFALRQRRCPNCGATF 130
XP_003964604  87 GVLEDDFTCLGILCAIFFFPLGLLFCFALRQRRCPNCGATF 127
XP_004071519  88 GVLEDDFTCLGILCAIFFFPLGILFCFALRQRRCPNCGATF 128
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