Conserved Protein Domain Family
MREG

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pfam15812: MREG 
Melanoregulin
Melanoregulin is a family of proteins found in eukaryotes. It is a putative membrane fusion regulator. MREG forms a complex with peripherin-2. It is required for lysosome maturation and plays a role in intracellular trafficking. It is a negative regulator of melanosome intercellular transfer and it regulates intercellular melanosome transfer through palmitoylation.
Statistics
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PSSM-Id: 434956
Aligned: 10 rows
Threshold Bit Score: 206.466
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Q0P4L7        41 VIDDDERNLWSSPHDLSHTEAVDDRMLQSWIQTRNQLEKDSEEWQKLNYEIYTLRQARREVRARWRRILEDLGFQ--KEA 118 tropical clawed...
XP_013034097  20 LARDEEQNLWSTPHDVTHTEADDDRVLYNMIVGRSQLDKDSEEWQKLNYDIYTLRQTRKEVRSRWKHILEDLGFQ--KEA 97 
XP_006009036  40 VRWDEERNLWSTPHDSSHTEADDDRELYNLIVTRDQLDQDSEEWQKLNYDIHALRQCRREVRNRWRKILEDLGFQ--KEA 117
EEN69034       8 RLKDDDLNIWHDPQDRTHMETDEDLELYNLIRRRDECPRGSDEWSHLNFDIHTVRTRRREIRDRWVKILEMLGFDdlQEI 87 
XP_006638281  43 RRRAEETNLWSEPADKSHTERDDDRELYNLLHRRAKTRRGSQGYRRLSVDIHAMRQVRRGVREKWKMILENLGFM--AEA 120
Q6GQM0        44 KRRDQETNLWSEPGDPSHSERDDDRVLYKLLQCRQQTQPGSRGYRRLSIDIEAMRDVRREVRDKWKMILENLGFM--AEA 121 zebrafish
XP_011602536  43 KRRDEEANLWSTPGDPSHSEREDDRVLYSLLQARNKTRMGSSGYRRLSVDIEAMRDTRREVRDKWQTILENLGFM--AEA 120
XP_005994095  40 RRRAEETNLWSEPHDKTHMERDDDRELYNLIHRRAKTRRGSEGYRRLSFDIHALRQVRRDVKDRWKMVLENLGFR--NEA 117
XP_008111538  38 KRKAEAENLWNEPVDSTHMERDDDRQLFTMLQKRSKLRRGSEGYRRLSIDIIAQRQIRQKVKDRWKHVLDALGFK--NEA 115
XP_015214974  19 TQRAEDWNLWSSPQDSSHTESDDDRELYNLLIMRNEVDKNTEVWEKLNYDIHTFRYIRREVKARWKKILLKLGFQ--KEV 96  spotted gar
Q0P4L7       119 ETLLSVTKQSTISNPKNMKRAMELLVKLSDNTTIF--PAGWDLPVRYLYIMDRLICLDAVDDFLNIAQKKYP 188 tropical clawed frog
XP_013034097  98 DSLLSVTKLSIISDSQNMGKARDILLKLSEETNIF--PTSWQLSERYLFVVDRLIALDAADEFFKMASVVYP 167
XP_006009036 118 DSLLSVTKLSTVGNSQNLNQTRELLLKLAEETSIF--SNNGGLPERYLFVLDRLISLDAAEDFLKTASKRYP 187
EEN69034      88 DNILTVTAVTKETISQG---AKDLFNELSEESSIF--GVSSTKPARYLYVLERLIHIDLAQTFVETAKQLYP 154
XP_006638281 121 ESLLTVSSSTTYANLRYATTARSLLQALHQDTSIF--DSKGAPPERYLFVLDRLIYLDAAEDFVDKARRFYP 190
Q6GQM0       122 ESLLNVSASASYDRMRNAASARSLLQTLHTETSLF--NSKEPPPERYLFILDRLIYLDAAEDFVAKARRFYP 191 zebrafish
XP_011602536 121 ESLLNVSAGASHDRMRNAPAARAMLNKLHSETSIF--SNKEPPPERYLFILDRLIYLDIADDFMAKAKRFYP 190
XP_005994095 118 ESLLTVTSNTPYNSMKNASEAKKLLETLAEETSIF--DDDSDPPDRYIFVLDRLIILDVAQDFLFKSRCYYP 187
XP_008111538 116 DGLLTVTSGTSYESLRKPQEARKLLNFLAEQTTIFgrNRGTGPPERYLFVLDRLLLLDIGDDFLSAARHFYP 187
XP_015214974  97 DTLLSVNKQSTLSDSGNFTKAREYLSKLLEETSLF--PKGCEAQERYLIVMDRLVSLDSAEDFLKLAMKKYP 166 spotted gar
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