Conserved Protein Domain Family
Pex26

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pfam07163: Pex26 
Pex26 protein
This family consists of Pex26 and related mammalian proteins. Pex26 is a type II peroxisomal membrane protein which recruits Pex6-Pex1 complexes to peroxisomes. Mutations in Pex26 can lead to human disorders.
Statistics
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PSSM-Id: 462109
Aligned: 10 rows
Threshold Bit Score: 408.774
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
NP_956214      1 MRSSSSVSPAGGRGSGSVRLVSPL------GCPLTALIDAAVEYLMVKKDFHAALATCEKGLESLD-------SFAEQEE 67 
EHB13701     262 MKSDAAISAGPLKGLGGPLRSSERartamaASPVVHLLEEAADLLVVHLDFPAALETCERACQSLA-------RDALGEE 334
Q8BGI5         1 MKSDASTSAAPLKGLVGPLRSSEPalalpaVSPAVHLLEEASDLLVVHLDFHAALETCERAWQSLA-------EEPV--- 70  house mouse
Q7Z412         1 MKSDSSTSAAPLRGLGGPLRSSEPvravpaRAPAVDLLEEAADLLVVHLDFRAALETCERAWQSLA-------NHAVAEE 73  human
ELK02627     144 MKSDLSTSAAPLKGVGGPLRSSEPvrivpaPSPAVVLLEEAADLLVVHLDFPAALQTCERAWQSLA-------NGALADE 216
XP_004083131   3 SCSSRQTPCSF-----GSVSSSPPps--saALQMINMLDSAAEQMMVYRDFQAVFDTCQRGLEKLA-------G------ 62 
XP_015208499   1 MRSSSSNSLAHVRGLGSVRLGSSPlls-qgSAQALSLLETAAEQLMVQRDFRAALDSCERGLDSMG-------SVPEQED 72 
XP_005988708   1 MRSLSSTSFVMPRGLGMTRPGSGLals-vgSAQALSLLDRAADLLAVQRDFAAAVETCEQGISCVD-------S---SND 69  coelacanth
XP_003220855   1 MRDDFSGALAAIAGSGGLLRSSEPlslspvLSPAASLLEDAADLLVMRKDFAAALEKCEKGCQSLE-------D----GD 69  green anole
XP_022266580   1 -mksdsaspaaalglwgpvrsseparaapaaaaaaalledaadllVVHLDFRAALRTCERAWRSLGnhsxtxiG-----F 74  dog
NP_956214     68 SCFKH--AELRSAFTIIGVQALAELNQWRTVLSWVLQQYGETENIPAKIIQMCillyvKVGERAVMKEAVCDWLHCSGNA 145
EHB13701     335 PAATS--LEVKCSLCVVGIQALAEMDRWREVLSWVLQYYQVPEKLPPKVLELC-----KMQEPGAMLNVVSAWLQDPDNQ 407
Q8BGI5        71 -SGTI--VEVKCSLCVVGIQALAEMDRWREALSWVLRYYQVPEKLPPKVLELCillysKMKEPGAVLDVASAWLQDPDNQ 147 house mouse
Q7Z412        74 PAGTS--LEVKCSLCVVGIQALAEMDRWQEVLSWVLQYYQVPEKLPPKVLELCillysKMQEPGAVLDVVGAWLQDPANQ 151 human
ELK02627     217 PTGTF--SEVKCSLCVVGIQALAEMDRWREVLSWVLQYYQIPEKLPPKVLELCvllysKMQEPGAMLEAANAWLQDPDNL 294
XP_004083131  63 TEDNRc-TELKTGFCILGIQALAELNRWHGVLAWVLQQYERQEDIPAKIMQMCillysKVGEAAEMQEAASVWLNCPSNC 141
XP_015208499  73 TSSNFrcSEVKVALCTIGVQALAELNQWRGVLPWILQYYGTPEKIPAKIMQMCillytKVDEPAVVLQAGGDWLRSPANQ 152
XP_005988708  70 NEENYrcSEVKVCLCVIGIQALAELNRWQEVLSWVLRYFQVPAKMPAKIIQLCillhsKVEEPQAMLAVGREWLTDLANQ 149 coelacanth
XP_003220855  70 PNSS---EELKCSLSIVGIQALAEMDRWRDVLPWILQYYQDPECWPPKILELCillhsKVEEPQAMLEIGSDWLHSSTNQ 146 green anole
XP_022266580  75 SAGSS--LEVKGSLCVVGIQALAEMNRWREVLSWVLQYYQVPEKLPPKVLELCvllysKMQEPGAVLEVVSAWLQDPDNQ 152 dog
NP_956214    146 SQSGFSTVAELYFLHILLPMGHVTEALEMLESdvgLVAFTDEQRQAARSLVDDQNQ---------------KnassSSSS 210
EHB13701     408 GLPEYGILAELHLQRVLLPLGHLAEAEELVVG---SAAFGEQQRLEMLQAVRTAKQ---------------Q----QKQE 465
Q8BGI5       148 GLPDYGSLARLHVFRLLLPSGRLSEAEELAVR---SAAFSEEQRVEALQAIHLARQ---------------QhtqeHTQE 209 house mouse
Q7Z412       152 NLPEYGALAEFHVQRVLLPLGCLSEAEELVVG---SAAFGEERRLDVLQAIHTARQ---------------Q----QKQE 209 human
ELK02627     295 GLPEYRTLAELHLHRVLLPLGYLSEAEKLVVD---PAAFSEEQRLDALQAISTARQ---------------Q----QKHE 352
XP_004083131 142 GSAGFRTVAELYLLHILVPLGHFEEAREFIAGevgGIAFA-ERKQAALNIVEEKAQ---------------Q----SREA 201
XP_015208499 153 SLPGYGAVAELYLLHILVPLGRLGEAQALAES---STAFSEEQRQVAVDIIEHKRS---------------S----SQPQ 210
XP_005988708 150 SLPTYSTVAELHLLHILLPLGLFAEAEDLAKN---PASFCAEQRRVALEVVRQRKErhveleepktltalnR----QQSD 222 coelacanth
XP_003220855 147 HLPSYGLLVQLYLFHVLLPLGHLAEAEGLLQG---CKALSEHQQAEAHESIEEKKH---------------Qwl-rQQEE 207 green anole
XP_022266580 153 GLPEYRALAELHLQRVLLPLGYLSEAEELVVG---SAAFSEEERLDVLQDIRKAKQ---------------Q----QKHQ 210 dog
NP_956214    211 SSNTNSDSVdvmetssVS-----KQGRLTLRLNSIIKLLSRGLSVASVRIRSISLRRVFLALMLLYLLIARLDPALPSAL 285
EHB13701     466 RSGFQEVPK-------TN-----QEGSFSHKFLSLLMLLRRLWDSAVSHFLSLPFKKSLLAALILCFLVMRFDPASPPSL 533
Q8BGI5       210 HSDSQEPQK-------LR-----QEGSFSQKLLSLLMLLRRLWGSVVSHLLSQPFRKGLLAALILCLLILRFDPAAPSSL 277 house mouse
Q7Z412       210 HSGSEEAQK-------PN-----LEGSVSHKFLSLPMLVRQLWDSAVSHFFSLPFKKSLLAALILCLLVVRFDPASPSSL 277 human
ELK02627     353 HSHSEENQK-------LN-----QEGSFSNKFLSLLMLLRRLWDSTVSHFFALPFRKSLLAALILCLLVVRFDPASPSSL 420
XP_004083131 202 ALRSGIHPAseisahpNS-----VKDAIIHKLEAMLRFLYRKILTAGSG--LFPLRRLFLIAVILYMLFSRLDPAAPSSF 274
XP_015208499 211 SPSQAQELEhkicrsaVS-----------QRLDSTVRLLYRALFLVRKRFRAFPFQKTVLAAVLLYLLLIRVDPAVPSAF 279
XP_005988708 223 RSTVRQE---------DS-----ETGFRSQKLLAMIRLFQRALVLIRSRLRSFHLQRMILATFLLYLVVIRLDPASPSTL 288 coelacanth
XP_003220855 208 CLVPEEPPD-------VAwkqhlGLA--SQKMLTVLAQLGRVVGSLAGQLCSIPYKKTLLAAVMLCLIIVKLDPASPTSL 278 green anole
XP_022266580 211 HLGSEEAQK-------LN-----QEGSFSHKFLSLMMLFRRLWDSIVSHFFSMPFKKSLLAALILCLLVVRFDPASPSSL 278 dog
NP_956214    286 PWLLRLHGLLQQMFNTMFGPYYKAH 310
EHB13701     534 PFLYQLAQLLHRIRKAMFAHLYQLR 558
Q8BGI5       278 PFLYQLTQLFRRIQKATLSRLYPLA 302 house mouse
Q7Z412       278 HFLYKLAQLFRWIRKAAFSRLYQLR 302 human
ELK02627     421 PILCKLAQIFHWIREAMFSSFYQLP 445
XP_004083131 275 MWISKLCQLFKQMWRTMFGPYYQTL 299
XP_015208499 280 PWISNLLQIFRQMWDTMFAPYYRAA 304
XP_005988708 289 PWISKLLRIFRHLWNSMFAPYYKAK 313 coelacanth
XP_003220855 279 PFIYRVLHLFHQARLAVFSSHCRPP 303 green anole
XP_022266580 279 PFLYKLAQLFHRIQEGMFS-LYRLP 302 dog
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