6T9I


Conserved Protein Domain Family
Spt20

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pfam12090: Spt20 
Spt20 family
This presumed domain is found in the Spt20 proteins from both human and yeast. The Spt20 protein is part of the SAGA complex which is a large complex mediating histone deacetylation. Yeast Spt20 has been shown to play a role in structural integrity of the SAGA complex as as no intact SAGA could be purified in spt20 deletion strains.
Statistics
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PSSM-Id: 463459
Aligned: 24 rows
Threshold Bit Score: 59.7325
Created: 24-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
6T9I_B        131 EQYLHSFEFHIY--ENNYKIcapansrlq------------------------------------qqqkqpelTSDGLI- 171  Saccharomyces...
Q0V0V1         59 KGKPPSLRIFLH--PKHFRI-----------------------------------------------------NDSADM- 82   Parastagonosp...
O14174         62 SKEEPSLILHIH--KFHFRF-----------------------------------------------------EQQDGA- 85   Schizosacchar...
Q54VY3        264 SSYKTSLYICLY--PIGYAId---------------------------------------------------nIYKDKI- 289  Dictyostelium...
Q2PDX8        342 REKLNTIVVNLYpgNKGYSLalhydehmvlnpqtnewsptdkdetssdaaglgtgtgshrsrpkplaqdesqsKTEAGHa 421  fruit fly
EDO44494        9 QDNLSTLVVNLYpnNEGYSLmlkgkng----------------------------------------------------- 35  
F4IDB2         61 PDHEVSFILSLY--PNGYSIg----------------------------------------------------KTSEAMq 86   thale cress
XP_001313599  103 STFSVSLHLILR--PKTFSFf----------------------------------------------------TTNPGId 128 
EAX98660       80 EDFNVSFNFEFH--PKVFTLal-------------------------------------------------gdGSNPRT- 107 
XP_001303029   89 YQERASIIIKFW--PEYFSIe---------------------------------------------------dKTDKRIe 115 
6T9I_B        172 -----------LTKNNETLKeFLEYVARGRIPDAIMEVLRDCN------------------------------------- 203  Saccharomyces...
Q0V0V1         83 -----------LDYSSPMRE-ILEHVKTRTIPHNMAEDFYAAD------------------------------------- 113  Parastagonosp...
O14174         86 -----------FTYNGPVKS-ILQYIRMELIPPDCLEVFRNSD------------------------------------- 116  Schizosacchar...
Q54VY3        290 -----------FTYNDKISKdFLNSISQGKLTPYIINILDQLSeqndqkqqqqqqqqqqqqqqqqqqqqqqqqqqqtnni 358  Dictyostelium...
Q2PDX8        422 khdfglvevlrWPYENDL---LLQCIDREMLPEFLMDLLVAETvslsdgeg----------------------------t 470  fruit fly
EDO44494       36 ----sesetikLPYEETQ---FLDYLDAQELPPILVDLLERSQa------------------------------------ 72  
F4IDB2         87 qisfrdvpkvlHPYDRAAEG-LLSAIEAGRLPGDILEDIP---------------------------------------- 125  thale cress
XP_001313599  129 v---------tESFEDEGAH-ILDFISRGYLPPRMFEELRKLN------------------------------------- 161 
EAX98660      108 -----------FQYNTKSRE-LIRCSETGCISEELLQLFNTFGk------------------------------------ 139 
XP_001303029  116 -----------FEYKQHICP-ILQDLEKCKIGKMFYTLLSNFK------------------------------------- 146 
6T9I_B        204 ------IQFYEGNLILQVYDHTNTVDVTPKENKPnlnsssspsnn---------------------------nstqdnsk 250  Saccharomyces...
Q0V0V1        114 ------IPFYDNCLIVELHDFRSSGVKPRDDTNSlgesgksafsihnynsfitpsphapyptnkadakasqteaqakdaa 187  Parastagonosp...
O14174        117 ------VKFYDGCLTVRIIDHRQSPSADQTVQPQpgs------------------------------------------- 147  Schizosacchar...
Q54VY3        359 yqnsneITYYNGCIVVNIKDYRGF-------------------------------------------------------- 382  Dictyostelium...
Q2PDX8        471 rvyakpSVFYAGCVIAQIRDFRQTFATSTNICDMkh-------------------------------------------- 506  fruit fly
EDO44494       73 ------NIFYSGCVIVEVRDYRQNLSSSS--YDTky-------------------------------------------- 100 
F4IDB2        126 ------CKFVDGVVICEVHDYRKH-------------------------------------------------------- 143  thale cress
XP_001313599  162 ------LVWYDGGLICEIDDQRRNNGN----------------------------------------------------- 182 
EAX98660      140 ------IQWTDGSIIVRITDYRFEPQ------------------------------------------------------ 159 
XP_001303029  147 ------LEFINGKIITSIIDFRNTPE------------------------------------------------------ 166 
6T9I_B        251 iqQPSEpNSgvANTGANTANKKASFKRPRVY------RTLLKPNDLTTYYDMMSYADN---------------------- 302  Saccharomyces...
Q0V0V1        188 vkEDKEnMP--APNQNGVSQKQ--AVKPRIW------TRVLFPTPQSHLADIQLLATTpmpdaatlkrmqaagragampp 257  Parastagonosp...
O14174        148 tnQQQQnNT--NPINNQPEDTKPNTNSPPVY------HTVLRPTPETLWQDLCLLSESf--------------------- 198  Schizosacchar...
Q54VY3        383 --AENEqIA--KTFNSKNMKPYPITVPIGTFkefiekRIILKPTMESLLFDIKKNCSTlnndnknnninninninnnnnn 458  Dictyostelium...
Q2PDX8        507 --------------------------------------iLLRPTNATLFAEVQQMGS----------------------- 525  fruit fly
EDO44494      101 --------------------------------------vLLRPTYQSLVCDVNNLTSD---------------------- 120 
F4IDB2        144 ---------------------TSSQVSPVIN------KLRLKMSLENVVKDIPSMSD----------------------- 173  thale cress
XP_001313599  183 ---------------------------------------VMRTLLSVAPSDIAALGP----------------------- 200 
EAX98660      160 ---------------------------------------------RTYTYPLTIGQDVils------------------- 175 
XP_001303029  167 ---------------------------------------------QYFFAELSISSDFi--------------------- 180 
6T9I_B        303 -----------------------------ARFSDSIYQQFESEILTLTKRNLSLSVPLNPYEHRDMLEET 343  Saccharomyces cerevisia...
Q0V0V1        258 -------tpmtavpptptfsngpspkrqkMVLDDSNVHEFESELYNATCPKLHLEPTKSFAESLALMEAI 320  Parastagonospora nodoru...
O14174        199 ----------------------------aNSLSDEAVLTLESNILLASEAPLFLTPAKSKAEMIQFMNQL 240  Schizosaccharomyces pom...
Q54VY3        459 nnnnnnnnnnnininnnnninnylnikesEIVNEEYLLNFEKCLLHAITPQLELSVNPNCF--FDQLETK 526  Dictyostelium discoideum
Q2PDX8        526 ------------------------------QLPAEDKLALESQLVLATAEPLCLEPDPSIGRQAINSQHQ 565  fruit fly
EDO44494      121 -----------------------------PSWSVDDKLALEAQLLLATEGPLCLNPNPEVGLVANQLQFN 161 
F4IDB2        174 -----------------------------NSWTYGDLMEVESRILKALQPELCLDPLPRLDRLSKNPLTA 214  thale cress
XP_001313599  201 --------------------------------------ECESEFLLVKYPLISFDSDIQISKVSRIASSD 232 
EAX98660      176 --------------------------fgaKALSEEEHLEAQKNILLVANPDLTLDPSPDVARINCVLDDR 219 
XP_001303029  181 ----------------------------rSDFKNTDYLTSEKIFIDLTNKNICTDPSPDVSRYNSILDWR 222 
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