Conserved Protein Domain Family
COPR5
?
pfam15340: COPR5 
Cooperator of PRMT5 family
COPR5 is a family of histone H4-binding proteins expressed in the nucleus. It interacts with the N-terminus of histone H4 thereby mediating the association between histone H4 and PRMT5, PRMT5, the Janus kinase-binding protein 1 that catalyzes the formation of symmetric dimethyl-arginine residues in proteins. COPR5 is specifically required for histone H4 'Arg-3' methylation mediated by PRMT5, but not histone H3 'Arg-8' methylation, suggesting that it modulates the substrate specificity of PRMT5. This family of proteins is found in eukaryotes.
Links
?
Statistics
?
PSSM-Id: 434649
Aligned: 6 rows
Threshold Bit Score: 222.456
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
XP_003414576  34 MGFATYDHc----CPMERETVKATGRLARGTQSIPNDCPVHGEGSHFEEEGFALdGEDFDGEPNA-WEQPKGvSGCLPKE 108
XP_008269277  82 ATFATADP-----SGPETEAETATDRLASGAQSVAPEVPAQGEGSHSEEEGLAGdEEESDGEPTA-WEVPEG-RRCWPTE 154
NP_001162592  24 AGLATADL-----SGGETETELDVDRLASGAQSIPTDVPTHAEGPSSEEEGFAM-EKEADGELYA-WELSEG-PACPPME 95 
1_pfamImport   1 AGFATADH-----SGQERATEKATDRLGNGSRTVPSSDQAHFVSCQEEECGGWLlKKKKDMQMNL-FFLAVF-TFLPPF- 72 
XP_007485633 110 VNLAMSDHfyqkkEGDEDEVMKWRPKLACGAQNVPIL----GEVDHPDEDEVQD---YGDSEEDLnWELEDRvENSLPPE 182
XP_003469676  34 VGLATADH-----SGPERETEPAVDRLVNGAQSVPSDIPNHSEDTCFKAEGFAV-NEESGGEKNT-WELWQA-TRFLPKE 105

XP_003414576 109 PTAD-LFNEDWDLELKMDQGNPYDADDIQGSISQEVKPWVCCAPQGDMVYDPSWHHPPPLIPHYSKMVFETGQFDDAED 186
XP_008269277 155 HSAE-LCSEDWDLELQAEQGNPYDADDVQGSICQEVKPWVCCAARGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED 232
NP_001162592  96 QASG-LFNEDWDLELKADQGNPYDADDVQGSISQEIKPWVCCAPQGDMMYDPSWHHPPPLIPHYSKMVFETGQFDDAED 173
1_pfamImport  73 ----------FNLSFK----T-ADADDIQGSISQEVKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED 136
XP_007485633 183 PRAEpPVKEDWDTELILDQGNPYGAEDIHRASIQDFCLWAPRAQQGDLIYDPSWHHPAPLTPHYSKMVFETGQFDDAED 261
XP_003469676 106 QTAD-VFNEDWDMELKADQGNPYDADDIQGSICQELKPWVCCAPQGDMIYDPSWHHPPPLIPHYSKMVFETGQFDDAED 183
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap