Conserved Protein Domain Family
TMEM33_Pom33

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pfam03661: TMEM33_Pom33 
Transmembrane protein 33/Nucleoporin POM33
This is an integral membrane protein family. Family members include TMEM33/Pom33 proteins. Budding yeast Pom33 is a transmembrane nucleoporin that contributes to proper distribution and/or efficient assembly of nuclear pores. Proteins in this entry also include Tts1 from fission yeasts, Kr-h2 (krueppel homolog 2) from flies and TMEM33 from vertebrates. Tts1 is required for the correct positioning of the cellular division plane by delimiting the actomyosin ring assembly at the cell equator. Kr-h2 is a member of the dosage-dependent hierarchy effective upon white gene expression. TMEM33 regulates the tubular structure of endoplasmic reticulum by suppressing the membrane-shaping activity of reticulons.
Statistics
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PSSM-Id: 461009
Aligned: 20 rows
Threshold Bit Score: 194.421
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
CCD78507      12 QQQNTLLSRLKSDYINTAMYFARLGTLFCCVVFFFaPIFSRshPSDlevWY-RRALLASAATSALRLHQRIkSLNtGFSR 90 
EEC16272      15 RGFSEVINHLSIHKIESLLWFTRMCTVVFTLLYII-PILGAn-PYT---CY-QRALISNAATSALRLHQRM-PTI-QLSR 86 
Q9XWV0        33 PAYSSISQYVSANTMECVLFAARVLTVFFALNYMI-PFIGLvpAHS---AY-YKIFAASAATFALRLHTRIqGQF-ALNA 106 Caenorhabditis ...
2_pfamImport   4 QTYSSISQYVSAHTMECVMFAARVLTVFFALNYMI-PFIGFipPHS---AY-YKLFTASAATFALRLHTRIqGRL-ALNA 77 
XP_004348619 121 AARRSLVQFAIANKLQLIAWIANLLCLINVLAFIV-PIGMDpsPIS----Y-YKVFRRGAVAYIVMLYQRH--GL-VFSR 191
4_pfamImport   4 TSLKSFLIGSKINMFQLFQFALRSLLLLYFVSFWI-PVLLS--SYVayvNF-FKVALINHASYLAFIHG----VP-RWSA 74 
XP_007407318  14 SSK-------RMSYMHLAWSLGHILVLLSTIWTFLgALFFKsrSTS----Y-YIACSGAILSWSIVVYKSL-GIP-SFSR 79 
Q803C2        14 PPQAGAAQFLLSNKLETAMWLSRLFTVYCSIMFIL-PLLGPqaAAN---FY-QRALLANALTSALRLHQRL-PHF-QLSR 86  zebrafish
EKC27828      95 qrpnTVLNFMLSNKVEAALWLTRIFTVVCSFLFIF-PILGGn-PYG---FY-QRALISNAATSALRLHQRL-PHF-QLSR 166
XP_002129462  18 RDTGSIMNFMAARRIGTAMWVMRCYAIFLSIQYMF---FCSafDMG---HYfQRAMLANGVVCALRLHQRV-PQF-RLTR 89  vase tunicate
CCD78507      91 EVLEVLISEDSSHYLLFSIMFAVLPPVTVSLVPIFLFALLHVASFTRVLLNasvslnsggtsdgsdapVGSSNMS--CVH 168
EEC16272      87 MFLSQLLIEDSCHYLFFSLIFLFAQPMTLVLLPVFLFALLHSASFTLTLLD-----------------KFGGRSG--FLG 147
Q9XWV0       107 QFIQRLIIEDSFHYLVYSVVFLMAAPVSMAALPVTIYAALHACTFMTKILR-----------------ETGHTSS--IIP 167 Caenorhabditis ...
2_pfamImport  78 QFLQTLVVEDAFHYLIYSVVFLMAAPVSMAALPVTIYAALHSSTFFVKIMR-----------------STGHNLP--LLQ 138
XP_004348619 192 NYLNSIIPDENFAYIMYCVVFSFADVHAAAVLPMAIFALYGFATFTPNVASail------------pqNLRSTIV--PRI 257
4_pfamImport  75 MYAERLFLDPATQALFFCLVFFFSPPYSLAMVPVFLQDMVHYSTYLQSLLQ-----------------VLGLADTk---- 133
XP_007407318  80 AYFQRAAMDENVQYLAVALYWFFSKPIYVTLLPFAIFSTFHSLTFVRTSLLpkipspkkdatgastssGTGSEGPqqVAI 159
Q803C2        87 AFLAQALQEDSCHYLLYSLILVNSYPITMSIFPVFLFSLLHATTYTKKVLD-----------------TMGPNSL--MFV 147 zebrafish
EKC27828     167 EFFGLLFLEDSCHYLMFSLIFMNGYPITMAVIPVFLFALLHACNYTKNILN-----------------VMGPDSL--QFM 227
XP_002129462  90 VHFSMLLQEDSAHYLIYSLIFLTCHPITIALMPVAVFALLHASSFTRQMID-----------------MHGSNSY--PFA 150 vase tunicate
CCD78507     169 HILqklIVKVNAHDQN---IL------------------------RIIALNEI-MLMVICIFMAVSGPRIFILPFI-YYP 219
EEC16272     148 TWL---VLLLEHQSNN---IL------------------------RLVAFTEI-FLMPLTIFSLLSGRSSLVTPFV-YYR 195
Q9XWV0       168 KLE----QFTAHQTQN---AL------------------------GIIACSEI-FLVPLLVSLIFSGKGSLLLPFA-YYR 214 Caenorhabditis ...
2_pfamImport 139 KIE----QFNTAQTQN---AL------------------------GIIACSEI-FLVPLLVSLIFSGKGTLLLPFA-YYR 185
XP_004348619 258 RGLvarLTAVGDQAKI------------------------------AAARLEL-ILVPILFIGLFSGE---FLPLIsYAN 303
4_pfamImport 134 -----vVTLVASKALVpltALiirdpsfptlatsakwvklysripQVAANIDL-AIGFAMIVELLLPSRNFLLLVL-YWQ 206
XP_007407318 160 AVSrsiQNWVKQNYES---AM------------------------YLVAIIEVvVIQGRVTVGALLFQNSFLHPLF-FAH 211
Q803C2       148 RNF---LNKLTSNQQN---IL------------------------KFIACNEI-FLMPATVFMLFSGQGSLLQPFI-YYR 195 zebrafish
EKC27828     228 RKL---IDKLQLQQIN---IL------------------------RFIACTEI-FIMPAIIFMMFAGKCSFFLPFV-YYK 275
XP_002129462 151 RKL---INHVAKHQAT---LF------------------------RFVALNEV-LILPTVVAMLIMGRASVFAPFL-YYK 198 vase tunicate
CCD78507     220 FLKMRYNSRRNPYTRNAFSELRVALQNVAYHTkcPALISRIIYGLINIVSRLGTS 274
EEC16272     196 FLSLRYASRRSPYSRTVFHELRLVTEHYASRPgcPAFLSRLLYKTIGLICQLSPP 250
Q9XWV0       215 FLSLRYASRRNPSTRQAFAQMRGSLQNVAMSSscPRPISSLIYRAIDFISARAPP 269 Caenorhabditis elegans
2_pfamImport 186 FLSLRYASRRNPSTRQAFYQMRVSLENVAQSTscPGPVRGFIHRAIGFISSRAPP 240
XP_004348619 304 FLNLRYV--QSAHTRRLLSDLKILGFQLTGHPrcPPIIGAAFVKLVGLLERMDPN 356
4_pfamImport 207 VMRVRYM--ISPQLQEAFRSLHASIFTIVNHPrcPAVIPSIYEKIRAFVAKTG-- 257
XP_007407318 212 FLRLRFY--LSPQTRAALSAVNTTIDHYLNHPscPGAAKTGVNVVRNLIIQYads 264
Q803C2       196 FLTLRYSSRRNPYCRTLFTELRILLEHFVMKPscPVFFRRMCLNSIAFVSRLAPT 250 zebrafish
EKC27828     276 FLSLRYTSRRNPYCRTLFTEMRLTVEHFTATPscPGIIRTACLKAIAFISRLSPP 330
XP_002129462 199 FVHYRYLSTRNPYSRVIFYELRMSAEVLSRNPncPSILSSSLLKGITFVSKLApp 253 vase tunicate
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