Conserved Protein Domain Family
FXYD7

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cd20325: FXYD7 
FXYD domain-containing ion transport regulator 7
FXYD domain-containing ion transport regulator 7 (FXYD7) has a potential splice variant with an additional 3 residues. In rats, expression of FXYD7 was restricted to the brain, with highest levels in the cerebrum, followed by brainstem, and hippocampus, and relatively weak expression in the hypothalamus. Immunofluorescence microscopy demonstrated colocalization with synaptophysin and modest colocalization with glial fibrillary acidic protein, indicating predominant expression in neurons and lower expression in astroglial cells. The FXYD7 gene maps to chromosome 19.
Statistics
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PSSM-Id: 410561
Aligned: 37 rows
Threshold Bit Score: 72.9755
Created: 8-Apr-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
 
putative trimer
Feature 1:putative trimer interface [polypeptide binding site]
Evidence:
  • Comment:based on structures of the Na+/K+ ATPase heterotrimer, composed of alpha, beta, and gamma (FXYD2 or phospholemman-like protein) subunits

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1              # # #  ##  ## ##  #  ### ## #                                  
P58549        12 PEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKKVk------------------CRKADSRSESPT 62  human
KYO33345      29 RDSGDPFKYDYDTLRLVGLVLAIVMFVLGILTALSRKFk------------------CKQSESSLSADP 79  American alligator
OCT73535      14 YGDKDPFRYDYDTVRMTGLILAIVMFSLGIIIALSNKFk------------------CKKRNPDGAQTN 64  African clawed frog
XP_005279553  13 RGHQDPFSYDYDTLRMVGLVLAIVMFVLGILTALSKKFk------------------CKKSDSSLSEAR 63  western painted turtle
XP_008115268  12 NSHMDPFTYDYDTLRTVGLILAIIMFVLGILIALSRKFk------------------CKKSDPSQSDPR 62  green anole
XP_025032148  11 SKPIDPFTYDYDTLRLVGMILATIMFVLGILIALSKKFk------------------CKKSDPGLSDPR 61  Burmese python
XP_027711284  56 SQEPDRFYYDYDSVRIVGLTLATIMFVLGILIILSKKVk------------------CRKSDSSPTIKN 106 common wombat
XP_021532267  12 PEEPDPFYYDYNTVQTVGMTLATILFLLGILIVISKCNpflghl--------glhfpCRLPSISHSLCP 72  Ma's night monkey
XP_017359670  12 PEEPDPFYYDYNTVQTVGMTLATILFLLGILIVITQPAnpvspsflpqplaaaacntCPRNLRCRPCLS 80  Cebus capucinus imitator
XP_017652383  12 PEEKDPFYYDYATVQTVGMTLATIMFVVGIIIILTQHAnpvslsfp---pqplavaaCRTLGSDSPLLS 77  Upper Galilee mountains bl...

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