Conserved Protein Domain Family
Gpi16

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pfam04113: Gpi16 
Gpi16 subunit, GPI transamidase component
GPI (glycosyl phosphatidyl inositol) transamidase is a multi-protein complex. Gpi16, Gpi8 and Gaa1 for a sub-complex of the GPI transamidase. GPI transamidase that adds glycosylphosphatidylinositols (GPIs) to newly synthesized proteins. Gpi16 is an essential N-glycosylated transmembrane glycoprotein. Gpi16 is largely found on the lumenal side of the ER. It has a single C-terminal transmembrane domain and a small C-terminal, cytosolic extension with an ER retrieval motif.
Statistics
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PSSM-Id: 461180
Aligned: 45 rows
Threshold Bit Score: 377.735
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_005850415       7 PVIVLLLRWGVGSAA----AYTEELALQQLSDGSVLAHFEFS---AAAPLh------AE---------HAGSFPAALLAL 64 
O94380             9 LFAYSLLSFSLTAATid-eTYDESLFIKSFSSRYSYVSFAFE---IGAST-------DSthssvfsesSFSLFPLSIARV 77  Schizosacch...
XP_013021264       7 vlVCLCSFFALGYASln-eQYNEALYLENLSNRHTYASFTFE---IDKKT-------NKengyafsepNYQFFPLSLARI 75 
XP_006681170      12 aLVASSSIRSLLASTlafePYSERLELSQMADGKVLAQFAFT---TLTDLs------NSasq----dnHYGLLPRSIGEV 78 
1_pfamImport       1 -IILFTAYFSLTASSpikdEYHEELFMKPL-GGYVYSYFQFS---TLWEIpf----lTKhna----fdHCHIFPRPMGEL 67 
Q949U5            15 QSFLVAIAFGSKEVE----EFSEALLLKPLPDRKVLAHFHFE---NRAPPs------NShg------rHHHLFPKAISQL 75  thale cress
XP_004247080      15 KSFGSIIAEEEDQIE----QFSEALLLRPLPDRKVLAHFHFE---SKVPPt------RThg------sHHHLFPKSIYQL 75 
KRH65825          53 FLVFLLSATSTQQEE----EFTEELLLKPLPDRKVLAHFHFQ---SDSPPlaaadesSSfd------rHHHLFPKSISQL 119
jgi:MICPUN_58571   4 aFLLVVLAASVGAAResreTFQEEALVRPLPDGRIAFVAHFR---QETSLv------AR---------HHETFPKAIAQI 65 
Q5KE79             9 LLFAPVFVAAVPSSN----SFHESLTLHPLPDGKLSVLFEFTtyfTQTKPt------SSip-----qyHHSITPPSLLLP 73  Cryptococcu...
XP_005850415      65 ARRHGVRQLELSLTQGRWTWEQQRQvAAGAGGSAAasrPAG-LELKVSfdgs-trdtQAAYSALTQALGGMLCAGIATAP 142
O94380            78 MDECQVSELHIRATRGRWDYENWKE-SPDNGFYSG---GLG-FEVWAFmand---psmkYWLKLTNQLSGLLCASLNYID 149 Schizosacch...
XP_013021264      76 MKDQKVMDLHVRATKGRWDYGFWKQ-PPDNGLQSG---GLG-FEVWASfidd---qdleAWYKLTSQLSGLFCFSSNNID 147
XP_006681170      79 VQTFDIDELHLTFTQGRWSYDRWGH-----SDFTA---PIG-VELWAWfnst---spdtKWKGLTNALAGLFCSSLNFLD 146
1_pfamImport      68 IQRYNVQELHVSLTKGLWRYEDWGY-----PVQTA---PPG-AELWAWfkhd-tidiDSKWRELTSALSGLLCASLNFID 137
Q949U5            76 VQKFRVKEMELSFTQGRWNHEHWGGfDPLSSMNAK---PVG-VELWAVfdvp-qsqvDTSWKNLTHALSGLFCASINFLE 150 thale cress
XP_004247080      76 VHKFRVQEMELSFTQGRWNYARWGGyDPISSRNAK---PPG-VELWATfdvp-qhqvDASWRNLTHALSGLFCASINFLE 150
KRH65825         120 VQKYHIKAMELSFTQGRWNYERWGGfDSISSCNAK---PPG-VELWAVfdvp-phqvDASWKNLTHSLSGLFCASINFLE 194
jgi:MICPUN_58571  66 ARATGVADAELSFTQGRWMYRRWGR----PPVGAK---PIG-AELWAAfaaesdevaDEGWANLTAMFGGQFCASLSALR 137
Q5KE79            74 LQTNDISELSISFVAGRWDQRRSSQsGPLHYLSGG---GGGeVRGWVRngneg-gseeeRWGTVTHALGGLFCAGLGPRE 149 Cryptococcu...
XP_005850415     143 RLAVMAaPAVGwfaqQQPAAVggGAASsgkqrrqgQRAQQIYAWLPQEGLCSENLAAWRRLLPCRHHAGLGALL-QPVQL 221
O94380           150 SSNTYQ-PQLS-----YPGSF--SF----------SNNTQYFASLPQEDVCTENLSPLFKLLPCKRKAGIASLL-DSHLF 210 Schizosacch...
XP_013021264     148 ELNTYQ-PLLS----FVPSSF--T-----------SSHSRYFASLPQESVCTENLSSLLKFLPCKGEAGIASLI-DSHLL 208
XP_006681170     147 QAVTSQ-PLLS----FLPSGS--HSKR--------EGLQIRYGSLPREAVCTENLTPWIKLLPCQAKSGLASLL-NAYKI 210
1_pfamImport     138 SHNTLS-PELS----LKPTGI--EDASrp-----lNHTHLRYATLPREIVCTENLTPWKKLLPCNLKRGLSALL-NSDNI 204
Q949U5           151 SSTSYAaPTWG----FGPNSD-----------------KLRYGSLPREAVCTENLTPWLKLLPCRDKDGISALM-NRPSV 208 thale cress
XP_004247080     151 SSTAYSsPQWS----FKSFAT-----------------NIRYGTLPREAVCTENLTPWLKLLPCRDKAGLSALM-DRPSI 208
KRH65825         195 SSTTYSaPEWA----FQSALG-----------------SLRYGTLPREAVCTENLTPWLKLLPCRDKAGLSYLM-DRPSI 252
jgi:MICPUN_58571 138 DEQVVVePALV----FRPWDG--SARVdrd--gisSDNRRRHGSLPAEAVCTENLTPWLKLLPCRDRAGIAALLgSRSSV 209
Q5KE79           150 AGENVK--TFGr--iYPPHRG--NP----------DGLTHFLLSHPHHNLCTENLTPFLFLLPSKGLSGLSALLsQPGII 213 Cryptococcu...
XP_005850415     222 AAAPYHSLGLQLwvpqgaplanasaSASSasARSQGGQqewLELRQVLTAVlpaad------------------------ 277
O94380           211 FDTDWHSFSIDV-------------YPS---ENQSLAS---VKMGIIIQAVvdverngrrkgkttfqpps-eychdedmd 270 Schizosacch...
XP_013021264     209 FDTDWYSLSIDI-------------APN---HPDDLSS---MKLIVKIQTVidvertnrrklgtkfppppefcnddiand 269
XP_006681170     211 FDGNFQSIGVHI-------------QPKCmtPDCVTMG---VEYRQTFAVVldpi------------------------- 249
1_pfamImport     205 YNTVYHSLGIHF-------------RPVCmdPSCTRTG---VELVQSVSLVydlv------------------------- 243
Q949U5           209 YRGFYHSQRLHL-------------STVEsgQEGLGSG---IVLEQTLTVVlqpett----------------------- 249 thale cress
XP_004247080     209 YRGFYHSQRLHL-------------ISNEfdLAAASSG---MVLEQTLTVVlqpvtlgsg-------------------- 252
KRH65825         253 YRSFYHSQRLHL-------------TMSTdpSDGSRSG---IILEQTLTVVvqpseqkag-------------------- 296
jgi:MICPUN_58571 210 FGAEYVSFTARV-----------------------RVRgdaLELTQSATLVvdan------------------------- 241
Q5KE79           214 FSWGFQSEGIEV-------------IMPNddHPEGKWT---GWWEGVVDLMppg-------------------------- 251 Cryptococcu...
XP_005850415     278 ----qqeqqQEQQGRglLEALFGSSPPA------ACPA--------------ADSSTLYLpggrsaAAAHYMakavaasr 333
O94380           271 slhclmsgySTEHHT--VDDLFHKVPKE------RCLLs-------------STFSDVFV-------------------- 309 Schizosacch...
XP_013021264     270 plrcltatyTSSSHT--LEDLFHKLPET------QCPLs-------------PSKDDILV-------------------- 308
XP_006681170     250 ------rtnSQKDWS--LESLFDRTFPK------ACPFslsttvhldilniqPDTVVILPdphidqSTSTA--------- 306
1_pfamImport     244 -----iigrDETHWS--IQRQFGQGLGL------TCPL--------------ATTSSVIVditsnaTGNTFKlypstydr 296
Q949U5           250 ----svesnMQPSWS--LSSLFGRQVVG------RCVL--------------AKSSNVYLqlegllGYESKNvdteieah 303 thale cress
XP_004247080     253 -mtssvgsiQQPSWS--LSTLFGRKVSG------RCVL--------------SNASNVYVqlepdlVSELKTtsetqqqs 309
KRH65825         297 -mnhvsetkIQPSWS--MSSIFGRKISG------RCVL--------------AKLSNVYLhaerglVSQLENlqkntakf 353
jgi:MICPUN_58571 242 ------kiaREPEGGhrLTSLLGVDRGGgangirACAA--------------ATSTAVHVqtkggtAFAFGGrkvhtava 301
Q5KE79           252 ------agvKNVKREtgLEKLFKKRLPP------SCPEtessv----irlilPENEKVNVepqgrvVGEWR--------- 306 Cryptococcu...
XP_005850415     334 gACRQh--------------------------DTPAgplLACDIaqqvqQAQQpEQQQAQISGqqqQQHlhppasllqag 387
O94380           310 --------------------------------SNGDk-iDTFSL-----DEAA---NIQIPIQ---STSd---------- 335 Schizosacch...
XP_013021264     309 --------------------------------KNSPslvVSYPL-----EMAR---DISVPVL---PEKr---------- 335
XP_006681170     307 ---------------------------------------VSYTY-----HLSTdPFQLNVRWN---DATv---------- 329
1_pfamImport     297 kVSNR---------------------------GGQRtvlAIYNLf---kQRTDaRYNIEVVYD----------------- 329
Q949U5           304 qlwkn--------------aefelslkperviRESCsflFIFDId---kSSDSePFDLGLTWKrpsKWSc---------- 356 thale cress
XP_004247080     310 dVGNLiseawsdmsfemsesavrvikeangflKESSl-lYEFSLe---nYSDSrPFDLEFRWKrpvTWSs---------- 375
KRH65825         354 aANDTgpedfrrnagfe---lsvtpervhaelEKSSsilYEYPIk---eYTDTeQFDLGLMWKhpiVWSs---------- 417
jgi:MICPUN_58571 302 dEGRRvdta-------------------vaadEASRpawLSWDV------SAAeDFDVAVRPGggdEGT----------- 345
Q5KE79           307 --------------------------------DGKWrqvMEWNAk----DREMvGKDLKVWWD----------------- 333 Cryptococcu...
XP_005850415     388 qgggAEGGPpqagalHLLPLQVVQHTIQRGPLSGTLVVGIRVPAAAAaraaa--eaagpQLLLHVMQLLPWQLRVDATSL 465
O94380           336 ---------------NHT-VTVDRSLSNDGNHWGSLSSTIYNPS-SS------------PRTIVYFEKFPWFVRVYLHTL 386 Schizosacch...
XP_013021264     336 ---------------PESPVFIERSLTNSGNHWVGIISIFTNPS-DE------------AYSIVYFERLPWYARVYLHTM 387
XP_006681170     330 ----NYRNP------KLAPIQTHRYLSGVGQEHGGVVIVFINDL-DV------------PMAATYMDSIPWIIKLFMHTF 386
1_pfamImport     330 -------KIrqnvanVPPVIYANRYITGYGQEFGGIKTKIFNRY-RQ------------PLKVLFLENIPWFVPIYFHTL 389
Q949U5           357 ----QQAP-----------LHSSRFLMGSGNERGAIAILLKATESQEklsgrdltngqcTIKANIFQIFPWYIKVYYHTL 421 thale cress
XP_004247080     376 ----QLAP-----------LQARRFLMGSGNERGAIAISLKSVGRSEyakssvneegrcLLRVDVFQVVPWYVKVYYHTL 440
KRH65825         418 ----PHGP-----------LYASRFLMGSGNERGAIAISLKSTPglvaan---nveercKLKVNVLQIVPWYVKVYYHTL 479
jgi:MICPUN_58571 346 ---------------VAPELYAERVVTGSGYHRGGISIELRRPEGSKsa---------sGTRARLFQTLPWYVRVFIHTL 401
Q5KE79           334 -----EERFeyprtiDPPAISVMKTVIDSQASDGTFQIKISNHENI-------------TREAIYSEIWPWWVKGWMSEM 395 Cryptococcu...
XP_005850415     466 QVLLDGQp-------lHPRSPQLVWQSLDVRP---DRT--ATLELLLRLPSTaAApagsdalqagrwheVRVQVGYRAAF 533
O94380           387 TITLNGT----------RINTKDFIEKLYYQPl-rDRKagTMMEIQFSIPPH-TN--------------LIVHFNVEKTP 440 Schizosacch...
XP_013021264     388 KITVNDK----------PISPLEFFQDQVYQPl-kDRKagTMIESRFEIPAH-SS--------------VVISYDIEKTT 441
XP_006681170     387 KVELENP----------SSNISDIIRQTYYQPa-iDRIrpNVLELDLVLGPK-SK--------------TTLTFDFDYTF 440
1_pfamImport     390 KVFSGDK------------ELQPLVKR--YFPg-kERVrpYYLELLIELPPR-SV--------------TSVSVEFDYAF 439
Q949U5           422 QIFVDQQ----------QKTDSEVLKKINVSPs-tDKVssGMMEMMLELPCEvKS--------------VAISIEYDKGF 476 thale cress
XP_004247080     441 KVFLDER----------LHSLADVVERTNVSPs-eDKVspGLMEIALRLPCDvHS--------------VILTLEFDKGF 495
KRH65825         480 QLVVDER----------PQALTDFVERMRVSPs-lDKVspGVMEMALQFPCEmKS--------------AVLSIEFDKGF 534
jgi:MICPUN_58571 402 AVEMDGVpvpvptsgaDVGANGGAVEALRWVPg-vDRRrpSTMELQVLMPASaSV--------------ARVSFKFEKAF 466
Q5KE79           396 AVCIEDE-----------GPRADLLKSISYNPsnpPDIppTTIHLSIQLPPR-ST--------------LVLTIPFTKLT 449 Cryptococcu...
XP_005850415     534 VSVFDHAPDASRGVDIPPALATLapdha----------------ctspsSPSSSSGDgssgpaappllrrlqagcaprqq 597
O94380           441 LRLDEYPPDANRGYNLPPAIISV--------------------------FDENNTKL----------------------- 471 Schizosacch...
XP_013021264     442 LRLQEYPPDANRGYDLPPSIVSV--------------------------FGKDDVEI----------------------- 472
XP_006681170     441 LKYTEHHPDANHGFELGFGVLTL--------------------------FPDSGLTFdkhhs--------------qsdq 480
1_pfamImport     440 LKWQEYPPDANHGFYMGAASVTA--------------------------LLPLARNYtapprdrslli-dsinasrngyp 492
Q949U5           477 LHIDEYPPDANQGFDIPSALISFpdhhasldfqe-----elsnspllssLKEKSL------------------------- 526 thale cress
XP_004247080     496 LHIDEYPPDANQGFDIPSALIRFpgiktkmdlfed---ksackspilskLQEESP------------------------- 547
KRH65825         535 LHIDEYPPDANQGFDIPSAIISFpdfhaglqfsd----ksqskspllskLQEKSP------------------------- 585
jgi:MICPUN_58571 467 LRISEFPPDANRGFDLPAALLSLppvsprdghefgesrlldlvegvaseVGDTHS------------------------- 521
Q5KE79           450 LKYTDHRPDAERGQEIPAGVLTLldlv------------------gergVPEAESEAspsswtspq------inalrsnr 505 Cryptococcu...
XP_005850415     598 YSGSGGGGLAPLPLPDLSMPFNVICFTSTLLAILLGGVANVVLRSPaeLAGQAASEGGAPAWRRK-L 663
O94380           472 CSLRTAALLMFIPTPDFSMPYNVIIFTSTVIALTFGGIFNLLTRRF--VPQQSKFQNRQPSMLQR-L 535 Schizosaccharomyces pomb...
XP_013021264     473 CQLRTSALLMFIPTPDFSMPYNVIILTSTVMALTFGGSFNFLTRRI--VPISELPKSQKPSLLQR-L 536
XP_006681170     481 RRIYTESLLVRLPTPDFSMPYNVITLTCTLFALFFGSVFNALTREFrpVEVTGGKVSPLQRIKTM-L 546
1_pfamImport     493 VRITTEVLIISLPTPDFSMPYNVICLACTVVALAFGPLHNITTKKFvlTSAEK------KSFIKK-T 552
Q949U5           527 VRSYTEVLLVPLTTPDFSMPYNVITITCTIFALYFGSLLNVLRRR---IGEEERFLKSQAGKKTGgL 590 thale cress
XP_004247080     548 VLWYTEVLLVPLTTPDFSMPYNVITITCTVFALYFGSLLNALRRR---VDEEERLLKNKAAKPSGpI 611
KRH65825         586 VLSYTEVLLVPLTTPDFSMPYNVITITCTVFALYFGSLLNVLQRR---VGEEERLLKDKVANKAVfL 649
jgi:MICPUN_58571 522 EGVYMQGALLTLPTPDFSMPFNVTTMVCTLMSLLAGALLTTLTRRPgwEGFGKLKAEQRKRLKslek 588
Q5KE79           506 ARVYTQRILLDIPTPDFSMPYNVIIMSSTVMAVFFGLMHGGLTRRWgwVEVPEDPEEPKEGVRMGek 572 Cryptococcus neoformans
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