1T9F


Conserved Protein Domain Family
beta-trefoil_MIR_SDF2_meta

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cd23293: beta-trefoil_MIR_SDF2_meta 
MIR domain, beta-trefoil fold, found in family of metazoan stromal cell-derived factor 2 (SDF-2)
The metazoan SDF-2 family includes SDF-2 and SDF2-like protein 1 (SDF2L1). SDF-2 is a secretory protein involved in multiple endoplasmic reticulum (ER) functions, including the misfolded protein catabolic process, protein glycosylation, and ER protein quality control. SDF2L1, also called PWP1-interacting protein 8, is an endoplasmic reticulum (ER)-localized protein that plays a role in ER-associated degradation (ERAD) of misfolded proinsulin in pancreatic beta-cells. It is a component of the endoplasmic reticulum (ER) chaperone complex and interacts with alpha- and beta-defensins. SDF2L1 may also act as a tumor suppressor that play an important role in a variety of cancers, such as breast cancer and ovarian cancer. Members in this family contain a MIR (protein mannosyltransferase, IP3R and RyR) domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Statistics
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PSSM-Id: 467764
Aligned: 26 rows
Threshold Bit Score: 305.35
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1T9F_A         7 VTCYSVLKFINAnDGSRLHSHDVKYGsGSGQQSVTAVKnsDDINSHWQIFPAln-akCNRGDAIKCGDKIRLKHLTTGTF 85  Caenorhabditis ...
NP_649527     27 VTCGSILKLLNSdYAFRLHSHDVKYGsGSGQQSVTGVEqkEDVNSHWVIKAQtg-elCERGEPIACGSTVRLEHLSTKKN 105 fruit fly
ELU12245      30 VTCGSSLKLVNTrSNVRLHSHDVKYGsGSGQQSVTAVDstDDNNSYWQVQAPttgaeCPRGKPIECGQIIRLLHVTTKKN 109 Capitella teleta
XP_013091012  37 VTCGSALKILNTaHNARLHSHDVKYGsGSGQQSVTGVDssDDHNSYWQVMAKtg-alCTRGNPVKCGQTIRLMHVATKRN 115 Biomphalaria gl...
XP_023933407  69 VTCGSVLKLLNTrASVRLHSHDVKYGsGSGQQSVTAVDssDDHNSYWQVQPKmg-gqCTRGNPVKCGQTIRLQHVTTQKN 147 Lingula anatina
RWS30213      32 VTCGSVIKLVNNnYNARLHSHDVKYGsGSGQQSVTATEdkEDSNSYWSVLGKng-dhCTRGQPIKCGSVVRLRHLASNKN 110 Leptotrombidium...
PAA80675      30 VTCGSVVKLLNMdHSVRLHSHEVKYGsGSGQQSVTGVEssGDSNSYWRVRARtg-vdCTRGYPVKCGSTLRLTHVATGRN 108 Macrostomum lig...
SVE83918      27 VTCGSAIKLQNLaYKIRLHSHDVKYGsGSGQQSVTGTDttDDVNSHWAILGPln-ktCKRGEPIECGSTIRFHHLTTRKF 105 common water flea
XP_012798115  24 VTCGSVLKLVNTdFNVRLHSHQVQYGsGSKQQSVTAVSdeMDTNTSWQVVERngspqCNRGRVIKCGQKIRLMHLSTQKY 103
XP_004345090  43 VTCGSVVKLTHApTGAKLHSHEVKYGtGSTQQSVTGFPqaDDTNSYWTVRGPhd-eyCERGHPIKCGDVVRLTHLNTRRN 121
1T9F_A        86 LHSHHFTAPLsKQHQEVSAFGSEAESDtGDDWTVICNgd------eWLESEQFKLRHAVTGSYLSLSGQQ-FGRPIhGQR 158 Caenorhabditis ...
NP_649527    106 LHSHHFSSPL-SGEQEVSAYGTDGLGDtGDHWEVVCSne------nWMRSAHVRLRHIDTGMYLGMSGRS-YGRPIsGQM 177 fruit fly
ELU12245     110 LHSHHFSSPL-SRNLEVSAFGEEGVGDdGDHWSVVCSgk------yWQRDEKIRLKHVVTDHYLHVTGDS-FGRPIhGQR 181 Capitella teleta
XP_013091012 116 LHSHHFQSPL-SHNLEVSAFGENGEGDeGDNWVIVCNgk------yWSRNERVRFKHVTTEYYLHMSGDT-YGRPIhGQR 187 Biomphalaria gl...
XP_023933407 148 LHSHHFQSPL-SRNQEVSAFGDGGEGDeGDHWAVTCSgk------yWSRTEPVRLKHVVTEHYLHVSGDT-FGRPIhGQR 219 Lingula anatina
RWS30213     111 LHSHLFSSPL-SGNQEVSAFGKAGEGDtGDDWTVTCSee------hWERDVNVRFKHVDTEMWLSTSGRS-YGRPIsGQL 182 Leptotrombidium...
PAA80675     109 LHSHVYSSPI-TNLQEVSAYGENGEGDlGDDWKLLCDsgdsadgglWRRDGRVRLRHAVTEQYLHVAGQR-FGRPIaGQA 186 Macrostomum lig...
SVE83918     106 LHSHLFSSPL-SGSQEVSAFGENGVGDtGDFWKVVCDgd------fWERDDSVVFRHVDTNVYLASSGHA-YGRPInGQL 177 common water flea
XP_012798115 104 LHSHHFQSPL-SPNYEVSAFGENGVGDeGDDWQVICDga------yWKQSSNIRLKHISTEGYLHLSGKQ-YSRPIsGQY 175
XP_004345090 122 LHSHQFQSPL-SGLVEVSAFGEGGNGDaGDNWKAECTgs------hWMRNADVRLRHVTTGQYLHITGRHqFGRPIqGQH 194
1T9F_A       159 EVVGTDSitgGSAWKVAEGIYIKH 182 Caenorhabditis elegans
NP_649527    178 EIVGVHKpqhGTRWTTAEGLFIVP 201 fruit fly
ELU12245     182 EVSGYSApndLNYWKAAEGIFVKP 205 Capitella teleta
XP_013091012 188 EISAYSGisdLNSWQAAEGIYIKP 211 Biomphalaria glabrata
XP_023933407 220 EVSAYHSpsdANLWQAMEGIFVKP 243 Lingula anatina
RWS30213     183 EVVGVSRpdsSSYWQTAEGIYIKP 206 Leptotrombidium deliense
PAA80675     187 EVSAVASprpGSHWTVAEGIFVKP 210 Macrostomum lignano
SVE83918     178 EIVGLTRldsSCQWKTAEGLYIHT 201 common water flea
XP_012798115 176 EVSSTPKltnAITWIATEGVYIDP 199
XP_004345090 195 EVAAYARpsnENVWRAEEGIYIKY 218
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