Conserved Protein Domain Family
F-box_FBXO47

cd22112: F-box_FBXO47

F-box domain found in F-box only protein 47 (FBXO47) and similar proteins

FBXO47, also called FBX47, functions as the substrate-recognition component of an SCF (SKP1-cullin-F-box) protein ligase complex. It probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation. It has a potential role as a tumor-suppressor gene. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

Links

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Source:	cd09917
Taxonomy:	Eumetazoa
PubMed:	1 link

Protein:	Representatives
	Specific Protein
	Related Protein
	Related Structure
	Architectures
Superfamily:	cl45894

Statistics

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PSSM-Id:	438884
Aligned:	19 rows
Threshold Bit Score:	54.0868
Created:	12-Jan-2019
Updated:	17-Oct-2022

Structure

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Conserved Features/Sites?
PubMed References ?

putative Skp1

Feature 1:putative Skp1 binding site [polypeptide binding site]

Evidence:

Comment:based on the structure evidences that other F-box superfamily members interact with Skp1
Comment:F-box proteins participate in SCF (Skp1-Cul1-F-box protein) complexes that function as ubiquitin E3 ligases, where the role of the F-box protein is to recruit target substrates.
Citation:PMID 17389369
Citation:PMID 11961546
Citation:PMID 12820959
Citation:PMID 20581844
Citation:PMID 17410169
Citation:PMID 27479325

Scroll to Sequence Alignment Display

Sequence Alignment

include consensus sequence

Format: Row Display: Color Bits: Type Selection:

Feature 1           #   #  ##  ##      # ##   ### #        
Q5MNV8        44 FKALPLEIFQIILKYL---SVKDISMLSMVSKtVSQHIINYI 82  human
RUS89553      48 FDTIPLELRFNIFQFL---SLEDLSILTITSKkMRNLAEAYR 86  eastern emerald elysia
XP_002591039 214 FEILPVEMIYNILYEL---SIVDLSILTIVSKaVRGLVECFM 252 Florida lancelet
ELU05123      69 LELVPLELKFLIFSYL---PVEDLSQLTITSKcLRNLVELYR 107 Capitella teleta
XP_013389795  55 FEILPPELKTRIFQCV---TIEELSMLALSSKnMRNRVEQYR 93  Lingula anatina
KXJ14579      36 LSVLPKEMCFHIFARV---PLVDLGNLSLTSRsMRDLVLEYI 74  Exaiptasia pallida
EFX87278      80 FEQLPTELIYYLLQFLpldDVTSIGKLGQTSKdMRNILIRWI 121 common water flea
XP_028396924  52 FSSVPDELLFCIFCYM---PLYDLASMALTSRaLRDKLMTFH 90  Dendronephthya gigantea
XP_023223478  41 FDLLPMEIRFRIFSYL---PADDLSILSISSKaIRNQIEVYR 79  bark scorpion
XP_029830458  66 LQRLPPELLVQIFMRC---EACSLGVLSMCSKaLRDRVAEFV 104 black-legged tick

Citing CDD

Jiyao W et al.(2023). "The conserved domain database in 2023.", Nucleic Acids Res. 51(D1):D384-D388.

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