Conserved Protein Domain Family
GT29_ST8SIA2
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cd23987: GT29_ST8SIA2 
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2
ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).
Links
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Statistics
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PSSM-Id: 467715
Aligned: 6 rows
Threshold Bit Score: 576.505
Created: 28-Nov-2018
Updated: 27-Apr-2023
Structure
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Aligned Rows:
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putative active
Feature 1:putative active site [active site]
Evidence:
  • Comment:based on homology to other members of the family
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                ###     
Q92186        91 TLSLRIRKQILKFldaekdisvlkgtlkPGDIIHYIFdrdsTMNVSQnlyELLPRTSPLknk--hfGTCAIVGNSGVlln 168 human
XP_005994027  71 TLSLKIRKQILKFldaerdisvlkgtlkPGDVIHYVFdrdsTMNISQnlyKLLPRVSPLknr--hfQNCAIVGNSGIlln 148 coelacanth
CAG29223      97 TLSNLIRKNILKFldaerdisilkstfkPGDVIHYIFdrqsTTNISEnryHLLPTVSPMknqhyrxXKCAIVGNSGIlln 176 zebrafish
XP_041442801  91 TLALKIRKQILHFldaerdisvlkgtlkPGDIIHYVFdrdsTMNISKnlyELLPRTSPLknk--hfKTCAIVGNSGIlln 168
NP_001081189  91 TLALKIRKQILHFldaerdisvlkgtlkPGDIIHYVFdrdsTMNISKnlyELLPRTSPLknk--hfKTCAIVGNSGIlln 168 African clawed ...
NP_001001604  91 TLSLKIRKQILKFldaekdisvlkgtlkPGDVIHYVFdrdsTMNVSQnlyELLPRTSPLkgk--qfPSCAIVGNSGVllg 168 chicken

Feature 1                       ##                    #                                          
Q92186       169 sgCGQEIDAhSFVIRCNlAPVQEyarDVGlKTDLVTMNPsviqrafedlvnatWREKLLQRLHslngSILWIPAfmarGG 248 human
XP_005994027 149 snCGREIDDhQFVIRCNlAPVQEyasDVGtKTDFVTMNPsviqrafedlvnetWKEKFLQRLQslngSIFWIPAfmakGG 228 coelacanth
CAG29223     177 ssCGREIDShDFVIRCNlAPVEEyaaDVGlRTSLVTMNPsvvqrafqdlnseeWVQRFVQRLQslsgSVLWIPAfmakGG 256 zebrafish
XP_041442801 169 sgCGKEIDShDFVIRCNlAPVEEyakDVGtKTNLVTMNPsvvqrafedlvndtWKDKFLQRLKslneSILWIPAfmakGG 248
NP_001081189 169 sgCGKEIDShDFVIRCNlAPVEEyakDVGtKTNLVTMNPsvvqrafedlvndtWKDKFLQRLKslneSILWIPAfmakGG 248 African clawed ...
NP_001001604 169 sgCGPEIDThSFVIRCNlAPVQEysqDVGtKTDLVTMNPsviqrafedlmnetWREKLLQRLHslngSILWIPAfmakGG 248 chicken

Feature 1                                                     ###                 ##            #
Q92186       249 KERVEWVNELILkhhvnVRTAYPslRLLHAVRGYWltnkvhikrpTTGLLMYTLATRfCKQIYLYGFWPFpldqnqnpVK 328 human
XP_005994027 229 EERVEWVNDLIIksginVQTAYPslRLLHAVRGYWltnkvlikrpSTGLLMYTLATRfCSEIHLYGFWPFprdhserpVK 308 coelacanth
CAG29223     257 EERVEWAIRLILlhtvnVRTAFPslRLLHAVRGYWltnhvqikrpTTGLLMYTMATRfCDEIHLYGFWPFahdpdgkpVK 336 zebrafish
XP_041442801 249 EERVEWVNDLIIkhhinVHTAYPslRLLHAVRGYWltnkvhikrpTTGILMYTLATRfCNRIYLYGFWPFprdlhqnpVK 328
NP_001081189 249 EERVEWVNDLIIkhhinVHTAYPslRLLHAVRGYWltnkvhikrpTTGILMYTLATRfCNRIYLYGFWPFprdlhqnpVK 328 African clawed ...
NP_001001604 249 KERVEWVNELILkhrinVRTAYPslRLLHAVRGYWltnkvhikrpTTGLLMYTLATRfCNRIHLYGFWPFpldqnqqpVK 328 chicken

Feature 1        ##               #                      
Q92186       329 YHYYDSLkygytsqaspHTMPLEFKALKSLHeqGALKLTV 368 human
XP_005994027 309 YHYYDSLtyeytsqaspHTMPLEFRTLYGLHqqGALKLTV 348 coelacanth
CAG29223     337 YHYYDTLtyhytssaspHTMPLEFRTLSALHrqGALRLHT 376 zebrafish
XP_041442801 329 YHYYDSLkygytsqagpHAMPLEFKALKNLHlqGALKLNV 368
NP_001081189 329 YHYYDSLkygytsqagpHAMPLEFKALKNLHlqGALKLNV 368 African clawed frog
NP_001001604 329 YHYYDSLkygytsqaspHTMPLEFKALKTLHqqGALKLTV 368 chicken

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