Conserved Protein Domain Family
Ndc1_Nup

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pfam09531: Ndc1_Nup 
Nucleoporin protein Ndc1-Nup
Ndc1 is a nucleoporin protein that is a component of the Nuclear Pore Complex, and, in fungi, also of the Spindle Pole Body. It consists of six transmembrane segments, three lumenal loops, both concentrated at the N-terminus and cytoplasmic domains largely at the C-terminus, all of which are well conserved.
Statistics
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PSSM-Id: 462824
Aligned: 117 rows
Threshold Bit Score: 172.9
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_015210884  13 KVICWRAAASiAWSVLLLPVITALFVFLsHLDLfhpvqwisdslsvlggsyvIFSVVL---------------------- 70 
XP_009268324  35 LVLRKRMIRLvLLTFLSTCTIFSVSTSNlNDRIsstislnr--------------------------------------- 75 
EIM21682      29 LVLRKRMSRVlVLSLVSKIAIFALSTSNvRDGFsiilspfgl------------------------------------qr 72 
XP_012188578  24 ALRPRQTRAFvLAAVAWHLFLTSALLSTlSLSLispltl----------------------------------------- 62 
XP_007397684  38 NVLRQRL----LSRTFLYSALFCWTLVI------------------------LTATAGrggvarlglvgalispffprtl 89 
EMD32361      45 AALRHRL----LYHIFAPSFLVSWLLVT------------------------IWSVWMqgglsglglggflsaplspwtl 96 
EPS94314      29 SVIGRRL----FYNILAPSLAYSWVLAN------------------------VWSKWSqggpsqlglwgsfvdcikpltl 80 
XP_003889770  24 VILRRRTYHF-----CLISYLLSNIV--------------------------LWFVMLdglpalwnglr--------itt 64 
EGG09745      18 VVLRRRACHF-----CVITFLTNLGL--------------------------LWVSMLdgspavwnflr--------vpf 58 
XP_775730     35 KFLAKRYMTLmSRVALWIAVLLSLFSAFvSGDI---------------------SKVPfavls----------------- 76  Cryptococcus ne...
XP_015210884  71 -------LCLvvLVVGFFDL----QYY-------TVVPSI----PCTK--IAL----IGKVLHPQQFIHSLAHCLMGLLv 122
XP_009268324  76 flfaavaFSLsvIPIIITRKla--------------------liTKPPpsPSSpsqrIKSFLLNNKTYSSTSVYALSAV- 134
EIM21682      73 ilfallaFILadIPVIITRKlallSSFfyvnnaySLTKQS----AKSQpaPVGpskhLKALLLDQKTYNLAVTYAFSAI- 147
XP_012188578  63 -aasllsFGLgvLPLLAKRK----RSL-------SQITTPparlPSSK--AQQ----LSAALSDPTLVTLIFQHVVAFV- 123
XP_007397684  90 glafiiwISGv-VPVLVLRK----VYL-------TASPAS----ASSP--SGV----FRDALNKSSTFRSLAVYLTSAS- 146
EMD32361      97 sfaavfwCLGv-VPVVVVRK----NYL-------TVTPTA----SLSP--STV----FQSTLTKTSTPPALLAYLCSST- 153
EPS94314      81 lhavaiwMLGv-VPALVLRN----RFL-------TATPTS----ASSP--SKM----FSAALVKRSTTCALVTYLASGV- 137
XP_003889770  65 wimgganWASatIPLMTLRR----LQL-------TASSLY----APNR--YAK----FWAVLKSTEFITSTLFCSISGS- 122
EGG09745      59 wimggavWASvtIPMMMLRR----SQR-------QKRPSS----CLTR--YQS----IVAVLGSAQHLAACVLLSISSL- 116
XP_775730     77 --sfpvfLSL--AFLLRVRK----SFI-------TQPYRPs--pRSSL--IGL----IVSSFWNQRVITLLFSYAVFSI- 132 Cryptococcus ne...
XP_015210884 123 swCAAVMIGgrYhvfAKPchs---------eesHQMCLNEYHLFFLLAGAFMGYSY-----------SLLSVVKNMNYV- 181
XP_009268324 135 --IYAISFL--AcvsTHEedaqftp--ftthkrRGWQFNERFIFFILNAIVLAISY-----------SIYQLWTDRFITr 197
EIM21682     148 --AYGAVYI--SclsAYEdeagftp--ftshirRGWQFNERFIFLFLNAALLGAVY-----------ALRQLWNDRFVTr 210
XP_012188578 124 --VLALGYAalLtyrKGGwapqi-----wveshASFYLNERFLYLVGQSIVLGAVYafvsrslpspqAVASPSFDASTLt 196
XP_007397684 147 --LLTAIHVvtAlvfDVRagrdprlslfvksrkHPYYLNGRLLYLISSQISLAAFY-----------VLRNVMMDRLAVr 213
EMD32361     154 --LVTFMYIfmTyvyGSSssedrhlsffvkskkHPYYLNGRVLYLISSQMVISAAY-----------FFRNALLDRFVVh 220
EPS94314     138 --ALAVVHMflAniyEPSpsghprfslfvksrkHPYYLNGRVLYMLFSQAVLASAY-----------LLRTVLLDRFAVr 204
XP_003889770 123 --LLCLTYV--SaalALNenpelgl-fksvpgrGVTQISERPIFLLASCWYTALCY-----------SFSAIYHGKWHYr 186
EGG09745     117 --LLWTCYV--AaanALNeepdlkl-fktmpgrGASQINERPIYLAASALFCAFYY-----------SFLLTYEQRFPSk 180
XP_775730    133 --TITNVWF--T---LLGredmtl---fnstprHPWQLNESRFILTASNACLFLVA-----------AARDILNDNLKAd 191 Cryptococcus ne...
XP_015210884 182 ------SFQTIQQYKYLrFKGtLPVVIKHSA-VQSLYSV-RNYCITYLFLgyiPRAWICTt--------------mNLSR 239
XP_009268324 198 fpsnisQSISERVLTHL-KRN-LASGVKFSIiTVLTCLS-------SYFL---LKKPIYRtlatfsls-tfrphlfSLLR 264
EIM21682     211 fpsnlsSSISSRAQSHL-KRN-VPMAMKFALiVVLTVLS-------SYLL---TKKSIYRtvaslsla-tfrphlfTLLR 277
XP_012188578 197 t---dtPVTIKHRVVAA-FTArLPRAALVAAlTSSASIL-------VYSI---VRIRMWStillv-------lgtrGVMR 255
XP_007397684 214 w---tgSMSARAMNEIP-SFM-LARILTVTAsALLLTAMgTVAHIVLFGC---ARAIVIPfvfklpv---lshllrPFLA 282
EMD32361     221 w---teLSTTTNPVQAR-TVR-LAQLLTMLVtVGIFSGLcVAGHTLLFGL---ARSIALPvvfripi---vsrflrPFMA 289
EPS94314     205 w---tqVPSQPDAPERH-PFR-LARIVGTLItIGLSVSLtTVAYATLFGC---VRSLVLPtvyalpy---ipqflrPFTA 273
XP_003889770 187 p---fdVSEHLTIPQRI-WNS-LDSRIEFVRrSIIYCSAtFLP---IYLI---SRRYLIRaivf--------skytQLTK 247
EGG09745     181 r---adQPEGLMISQRI-LRT-LPTVFTRANrFSFLCSApFLP---FYLI---CRRYLIRaivf--------skyvQLTK 241
XP_775730    192 -----wPRERKPFAQAV-KIAlFDNVWGSSR-IGFTFLWsISTPFAYCWLg--LRSFIWQwvnwrlwgvavrpflgSFAR 262 Cryptococcus ne...
XP_015210884 240 DSTLHALdTLAGllDFSLM--FHLWITGTFLLVMWYITWLLFRIYITEMYW---FPVQSTfSENASQCLPKVLTGqQPPI 314
XP_009268324 265 QNNL----------SFGLI--LRTMLFTISLTTTWEVANTLFDVYSVHP-----MLISKV-SPASNDCLLDGLGC-EDTY 325
EIM21682     278 QNNV----------TFGLV--LRTTVFALGLVSSWEVTNTLFDIYSVHP-----IIISKI-APNPTDCLISGMQS-TDFY 338
XP_012188578 256 RLLVPSFrVEFAffEVS----VRSVLFSIAATCAVETAYLLLDVYLSHPL----PPVSKY-AKFPNRLLLDGIEE-PVLF 325
XP_007397684 283 HFLRGPFaLTLLtrHTGLI--FRAFMLGFLTISTWDFAENLFDTFVAEP-----INVAQA-TADPAVTLVSGTTS-QDLY 353
EMD32361     290 HFLRGRFtLTLLarHWSLI--TRTFYLGITTLAGWEFAESAFDEAVS---------VSHH-TGAPTHILVSGTTT-ADAY 356
EPS94314     274 HFLRGPWtVTLLlrNWSLV--WRTFFLGVTTAACWELAESPLDEPVS---------VAHV-TADPDLTLVSGITS-TDGF 340
XP_003889770 248 HIKPHMVmLIKFdsVFTLTstIRLVMINVLLISMWEIVQALWDVYSTHP-----LDLSRF-DTEPNQCLLEGIRS-TDPR 320
EGG09745     242 FIKPHLVmMIKFnsIFTFTsnLRLVMLNWLMVSCWEVVQAFWEVYLTQP-----LAISHF-AEEPNRCLLEGLRS-VDMR 314
XP_775730    263 STSKTP-----G--PWALL--GPMLTLNMLTLLALQFPVKGLAAYTTQP-IhfdEFYKKS-PLSLEIYLITALKS-QDPY 330 Cryptococcus ne...
XP_015210884 315 LKFLALQDLALLSQNSP----SRRQEVFSLSQPGGhPhNWTAISGECLGLLSDLTRRLVayheavasngrvkqqsagsdk 390
XP_009268324 326 YRHLAYLEFVMVFSTDK----QRRLSVYGDINRNP-T-SWDKYLGLAVKEMSDGRNKVLsrgatsdaaidkpfhhlntps 399
EIM21682     339 YKYFAYLEFVKVFSSSQ----ERRQEVYKDIHRKP-S-SWDKILSVAVQELVEGRTKVLtkgvptnktptvvnstpdatt 412
XP_012188578 326 FSNHAFSELARLSAGDK----EMRGLIYRDVGGDV-T-AWMQIRDRCLGLLEESRLFVVrrgqvatkpqasmpstsqpqq 399
XP_007397684 354 YKHFAFAELAQFARDEThagsTRRVALFTDQKYNP-N-LWSAFAREALLTLGRDYQLLLrrgappaaapapappakklda 431
EMD32361     357 YKHFAYSELRELACDESpsgsARRTELFADQKYNP-S-LWATLAREALLILGRDYQLLLrkgqpeipapapppppaqakp 434
EPS94314     341 FKQFAYAELERCASDDSasarSRREALFADQKYNP-N-LWASLCRESLLTIGKDYQLFLrrgqpvsaaptpappkiatpl 418
XP_003889770 321 VQNYAIRELAHISWSDP----ARRSTIFKDIRASP-R-LLNLIIEECLNIIDTTRATIEsggqpiqkisaaqtsvgphrp 394
EGG09745     315 IQYHAIVELAQISWSDP----ARRVTIFQDIRTQR-K-IFNAIVEECLSVISATQRMVIsrgempppvesigtqamstpl 388
XP_775730    331 YLQFTLMELLRVVSIP-----RHRKIFFDDISKSP-S-LISQLCQELLLQFGKVHNVLVnrgvtiqpqntksspvaasgi 403 Cryptococcus ne...
XP_015210884 391 ksssssssssssepsglgelagwpvqtpragaglrtpgsvlarsslgglrspltapFTPDLGSpfgSPAIQrfartldpa 470
XP_009268324 400 tatstatsssgkhlrvlqdekiyqrpprntfestvdqsqspkstpssllkdapkplAKGTQd------------------ 461
EIM21682     413 sssklrvvdnqeif------------------------------------------------------------------ 426
XP_012188578 400 qktsakppq------------------tiwdqlaagqtapkdstppstsspatapsTSTTVSTppqQQPAPllsiqslsk 461
XP_007397684 432 ppqipktpfik---------------------------epvlkqksasplhsaletiasdgsvtaalasTAeagas---- 480
EMD32361     435 plpaqpiqiir---------------------------gpvlkaspssplrnaldtiasdgalpaavssTAeaah----- 482
EPS94314     419 pakptqlirg-----------------------------pilkgtpasplraaldtlasdgplstavgtTAdgaas---- 465
XP_003889770 395 spgthsav-------------------ktdlpqlfntsshpnsmkqvflrkllsseSGQEPTApgsTTFQPsatslkkek 455
EGG09745     389 ntktsdhgrp---------------alvkdlpqlfnaqpqsdslkktllsklltspAETGSETtstPSIPTvqptsng-- 451
XP_775730    404 stahderkis----------------irqadifrplakpkstfnlksildgpiqatA---------PSPVVklg------ 452 Cryptococcus ne...
XP_015210884 471 spwygsvqsphvmRRGPKLWTSSTDTLANgsp-----avSPAPEPRV--------------------------------- 512
XP_009268324     --------------------------------------------------------------------------------    
EIM21682         --------------------------------------------------------------------------------    
XP_012188578 462 tslnlitlawkllPSDAKHVLFGARRQQT--------------------------------------------------- 490
XP_007397684 481 --------qipelFRSVLPSQTKAV--------------AETAGAAVetvkkgeqeimqlaalpgkwkgrlqqelva-qs 537
EMD32361     483 ---------lpelFRSVLHT-------------------DTAAQTAVatlrkkeedvkglvqrthnrwrdalaafaedgl 534
EPS94314     466 --------hipelFRS-----------------------VRPAAKAVeavqkgeervvglieqtrskwrqrfdgvvrsra 514
XP_003889770 456 tesdyqipdiflrDQSRKLASKSTSDLSTgdnlkpspspQSSTKALQsstpqkrekivpkiwki---------------- 519
EGG09745     452 -------yqmpeifQSPRKLDRSIADTKS----------KSSSLALPpstpkke-------------------------- 488
XP_775730    453 ----------qagTLAIKHVESVQDRVVGriegnpvggaIVSEAKGArkgv----------------------------- 493 Cryptococcus ne...
XP_015210884 513 ---------------------------SPaehkpsffslwlqnrreqvktflakrvlVMYLFNKLPEASSQALF-----A 560
XP_009268324 462 ---------------------------------------------------------AVIGFDKLLPKDLLRMLrkilnG 484
EIM21682     427 -----------------------krnpkstvdnfiadvqvdkkasmfskqtenvpadQGIGFDKILSPEIVKTLknsiyG 483
XP_012188578 491 ------------------------------------------------------------LLGESPSSLASSVI-----A 505
XP_007397684 538 psavrraaarlerwwhrervhkvveaaLP-------------------------------------NRKLDGLA------ 574
EMD32361     535 pkgvleavtevrgwwsrervhkrveasLP-------------------------------------NRQLDVLV------ 571
EPS94314     515 peaafaavrevrewwtrerlnrkvemcLP-------------------------------------NRRLDALV------ 551
XP_003889770 520 -----------------------------------------flhspllksseagsrlEDWLFSPSMTDELEKCL-----S 553
EGG09745     489 ---------------------mikaesFSrtqkiipkgwemvrkirgvgsserirslENWLFLPSVRMELRRTL-----D 542
XP_775730    494 ------------------------newAG---------------------------------KEWGRRSVRSVL-----G 511 Cryptococcus ne...
XP_015210884 561 -DSQAHIWA---------------LEGLSNLVAASYTEDRFGVVQTTFPNILSTMLTLLEAVDKH------------F-- 610
XP_009268324 485 -NEQAVVNAkiklmapemklvslsALGLAYLGAASINEDQYGLIQHSIPHVIAQLTETLIVYERF--------------- 548
EIM21682     484 -NEESNVNAkirllapdiklvslcSLGLAYLGAASIQEDEFGLIQHNIPQVIHEVTSTLLTYEEL--------------- 547
XP_012188578 506 rDAHRTICA---------------ALTLKSLLCQSLTEDPYGTVSKDIKRILTAFVGLDSEIRTLgmq------leaQar 564
XP_007397684 575 ------------------------ADALCSLVCASLTEDRYGVVQRDIPRILEALLSFLGAVEDYqseii--tkypvPsp 628
EMD32361     572 ------------------------VDVLSAFVCASLAEDQYGVVQRDIPKILEALLSFLQAVEDYqaevn--amytpPsq 625
EPS94314     552 ------------------------IAVLCHLVCRSLTEDRYGVVQRDIPKILEALLSFLTAIEEYqsein--klhvpLtp 605
XP_003889770 554 -KRQLCMFS---------------VEAVTNFTCASLTEDQYGVLQDQIPRIMESLVDCFDALDRLrintcaefgvqpPp- 616
EGG09745     543 -NHRACALA---------------VEAVTNLMCASLTEDQYGVAQDQIPRVMECLIECLETVKAFslticdeygatsNhq 606
XP_775730    512 -EVLVAQRV---------------IEILVILSIASIEEDTYGNVQQVLPAILEAIVRFREAIFALevq------llaQtr 569 Cryptococcus ne...
XP_015210884 611 ----------KLPHASSKPVQSsgsledTtyktlRFALRASLKTAIYRITVTFGEHLNAVEVSAEHRKRLQ 671
XP_009268324 549 ----------------QSELLKstthihE-----FNTRMQELRNALSVILVAFKDYIATFNLDEQVSGRVD 598
EIM21682     548 -------------QIDLEKLTKnsnhlkE-----YSTRVQEIQNALSILLFAFKDYVKSFNLDEKTQKRVE 600
XP_012188578 565 eiddklerveADGDGQSKQGEGr----------------GEVQDELKRVWTAGGAGQLDLYLVAS-MREIL 618
XP_007397684 629 eemgqlnakeAAEMQELALDLAra--gdA-----LSEMTDPLKDSIVRIVRTFGDKLSAFKFPPRTARKLQ 692
EMD32361     626 eefanlspkeIVQKDILAMEVAra--seT-----LSEASDALKDGVVHIVRTFGDKLTAFKFPPRTARKLQ 689
EPS94314     606 ddiqqlpvkeLAQRERVALEVAra--geV-----LSEVNDAIKIGVGQIARTFGDKLAAFKFPPRIAYKLQ 669
XP_003889770 617 ---------vQATAPASSELDPvqihfhLtldehLHPLLTRLKAGIFGITDQFKPFLKEMSFSPKIDQWIQ 678
EGG09745     607 dqndddqtdnGAKRIRDAEl-------rEsmdefVTPLLTRLNDGSVGILNQFGPYLKEWSFSPKTDKWIQ 670
XP_775730    570 ---------lLGPAQSGAMDEVk----kD-----LYVAIGSCDKAVKRIADTFGQSLSSFRFPPSVAYGLG 622 Cryptococcus neoformans ...
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