2POP,1M4M,5YUD,3M0A


Conserved Protein Domain Family
BIR
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pfam00653: BIR 
Inhibitor of Apoptosis domain
BIR stands for 'Baculovirus Inhibitor of apoptosis protein Repeat'. It is found repeated in inhibitor of apoptosis proteins (IAPs), and in fact it is also known as IAP repeat. These domains characteriztically have a number of invariant residues, including 3 conserved cysteines and one conserved histidine that coordinate a zinc ion. They are usually made up of 4-5 alpha helices and a three-stranded beta-sheet. BIR is also found in other proteins known as BIR-domain-containing proteins (BIRPs), such as Survivin.
Links
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Statistics
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PSSM-Id: 459891
Aligned: 74 rows
Threshold Bit Score: 49.5803
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2POP_B     24 RLKTF-ANFPsGSpvsAS--TLARAGFLYTGEGDTVRCFSCHAAVDRWQYGDSAVGRHRKVSPNCRFIN 89  human
Q8UVF8    267 RIQTF-LAWIyPVn--KE--HLAEAGFYSTGNGDHVVCFHCGGGLQEWKENEDPWDQHAKWFPGCKFLR 330 chicken
Q7QHS1     26 RIRSF-ESWRfGHmqnPT--RLAVAGFYYTGTDDEVRCFQCDAGLRDWLVTDDPWQEHARCFAECTFLR 91  Anopheles gambiae str. PEST
Q91EW1     84 RLKTFkK-WPvg--lgQSkeEMVEAGLCYSGRGDQVECFCCGESICDWRVGDDPWRRHIEANMGCQFVV 149 Cydia pomonella granulovirus
Q8B9M2    134 RMDTFvNFWPgALr--DMitNIAEAGFFYTGRGDETVCFFCDCCVRDWHTNEDAWQRHVTENPQCYFVl 200 Rachiplusia ou MNPV
Q6JPG0    162 RQSSF-EEWPiSLkslKT--QLAYTGFFYTQKGDVTICFHCGLVLKDWYIHDTPINEHAKWFDKCKYLT 227 Neodiprion lecontei nucleopol...
Q6R7D0     13 RVNSF-GGWSkQLrpnKD--TLAPAGFFYTGMGDKVKCFACGLEVIDWDPTDNPWTEHGKFSGDCLYLK 78  Ostreid herpesvirus 1 (isolat...
P41436    111 RVKSF-HNWPrCMkqrPE--QMADAGFFYTGYGDNTKCFYCDGGLKDWEPEDVPWEQHVRWFDRCAYVQ 176 Cydia pomonella granulosis vi...
Q9EN27    110 RLKTY-KEWPiSMpisTE--KLAEAGFFYTGKSDKVKCFYCDGGLNKWETDDDPWIQHARWFDKCDYVK 175 Amsacta moorei entomopoxvirus
XP_308529 175 RLATF-KEWPkSMpqtPE--RMADAGFFYTGKSDVVACFYCGGNLRDWLAEDDPWVEHVRNFSECPYVK 240 Anopheles gambiae str. PEST
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