Conserved Protein Domain Family
FH_FOXQ2-like
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cd20035: FH_FOXQ2-like 
Forkhead (FH) domain found in Forkhead box protein Q2 (FOXQ2) and similar proteins
FOXQ2 is the neurogenic ectoderm specification transcription factor that controls aboral development in cnidarians and anterior identity in bilaterians. It plays essential roles in epidermal development and central brain patterning. The foxQ2 gene is absent in placental mammals. The FH domain is a winged helix DNA-binding domain. FOX transcription factors recognize the core sequence 5'-(A/C)AA(C/T)A-3'.
Links
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Statistics
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PSSM-Id: 410809
Aligned: 32 rows
Threshold Bit Score: 139.683
Created: 18-Dec-2018
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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putative DNA
Feature 1:putative DNA binding site [nucleic acid binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1              #                 ##  #                    ## ##  #      #        ### #    
NP_001098411   87 KPAQSYIALISMAILDSdeKKLLLCDIYQWIMDHYPYFKs--KDKNWRNSVRHNLSLNECFIKAGRs-dNGKGHFWAIHP 163  zebrafish
XP_002165467   77 RNTPSYTAIIAHAILSSkeKKLPLGDVYEYIAENFPEFLk--KGQGWRNCVRHNLSLSECFVKAGRa-rNGRGNYWGIHP 153  Hydra vulgaris
XP_002166935   65 EKIASYTEMIAKAIFSGkgNMSTLQDIYEFLIENFPILKs--RGKSWKNSVRHTLSLNEWFVKIPRt-dNGKSCYWSIHP 141  Hydra vulgaris
ELT88538        1 KPDEPYMTLIVKAIMSTadHRMVLADIYLWLMDYSPYYRl--TKSSWKNSVRHNLSVNECFVKSERa-rNGRGFFWTVHP 77   Capitella teleta
ELT94607      156 PPSESYVTMIGKAMMSFpeREMVLGDLYTYLTETYPYLRt--AKSSWKSTVRHNLSVCPCFVRGRKa-rQGRGYLWGVHP 232  Capitella teleta
XP_004207988   29 DNNLSYTAMIAQAIMVSscKRLTLSEIYEYMANTFEILKk--RGTGWRNCVRHTLSLNECFLKLHRp-eNGRSCNWTVHP 105  Hydra vulgaris
PFX27449       88 RFSMTYVALIASAILRSpeKRLTLAQIYQVIEKMFPEFTv--SRAGWKNTVRHNLSLHECFVKGDVa-aNGKSCYWHIHP 164  Stylophora pi...
ELT99224      167 KPKMTYVEMIAKVMLTApdYQMVIADIYAGLELAYSYFK---NSTSWKGTARHCLSAYDCFVRTNKr--LDKSSYWTIHP 241  Capitella teleta
KII73047        7 QRYPSYLIMVIKAILNSpeKRLLLQDIYKYIKHNYPHVIs--NHVSWQNSVRHNLSTHGCFYRTRNi--NRGASFWGIFD 82   Thelohanellus...
NP_001071789  214 RPPHTYPALIASAILDSpgHLITLRGIYDYIMNHFPYYKychDKSAWQNSIRHNLSLNQCFVKVPRyenAAKSNYWTMTR 293  vase tunicate

Feature 1                           
NP_001098411  164 anfqDFSNGDYHRRRARR 181  zebrafish
XP_002165467  154 ryikNFSLGDYRKRRASH 171  Hydra vulgaris
XP_002166935  142 iylnRFRKGDFQKQRKSG 159  Hydra vulgaris
ELT88538       78 acvqLFQDGDYSRRSARA 95   Capitella teleta
ELT94607      233 aymqNFEKGLFTIRAAKR 250  Capitella teleta
XP_004207988  106 ayfeAFSKGDYRKRRANR 123  Hydra vulgaris
PFX27449      165 aymaRFSKGDFRKRPSRE 182  Stylophora pistillata
ELT99224      242 dcvqLFKEGKFKKSDFQA 259  Capitella teleta
KII73047       83 hfipYFEKNDFSRRWATG 100  Thelohanellus kitauei
NP_001071789  294 egfeEFGNENSFKRRRRR 311  vase tunicate

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