1FZG,1JFE,2FIB,1DEQ,1FZG,1JC9


Conserved Protein Domain Family
FReD
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cd00087: FReD 
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Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular arrangement called the disulfide knot. The C termini of fibrinogen chains end in globular domains, which are not completely equivalent. C terminal globular domains of the gamma chains (C-gamma) dimerize and bind to the GPR motif of the N-terminal domain of the alpha chain, while the GHR motif of N-terminal domain of the beta chain binds to the C terminal globular domains of another beta chain (C-beta), which leads to lattice formation.
Links
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Statistics
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PSSM-Id: 238040
Aligned: 57 rows
Threshold Bit Score: 200.93
Created: 30-May-2001
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 3 residues -Click on image for an interactive view with Cn3D
Feature 1:Ca2+ binding site [ion binding site]
Evidence:
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                                                                     
1FZG_F     61 ITGKDCQDiankgakqsGLYFIKPLkan----qqFLVYCEIdgsgnGWTVFQKRLDGSV---DFKK-NWIQYKEGFGHLS 132 human
NP_033771 292 PVFQDCAEikrsgvntsGVYTIYETnmt----kpLKVFCDMetdggGWTLIQHREDGSV---NFQR-TWEEYKEGFGNVA 363 house mouse
AAK83349  246 DFPADCSEvftrgqktsGIYPIKPNqs-----epFYVYCEItp-dgAATVIQRREDGSV---DFDQ-SWEKYEHGFGKLE 315 zebrafish
AAD45920  241 DLPADCSAvynrgehtsGVYTIKPRns-----qgFNVYCDTqs-gsPWTLIQHRKDGSQ---DFNE-TWENYEKGFGRLD 310 house mouse
NP_055310 241 GIPAECTTiynrgehtsGMYAIRPSns-----qvFHVYCDVis-gsPWTLIQHRIDGSQ---NFNE-TWENYKYGFGRLD 310 human
AAC97965  187 RPPRDCQElfqegerhsGLFQIQPLgs-----ppFLVNCEMts-dgGWTVIQRRLNGSV---DFNQ-SWEAYKDGFGDPQ 256 house mouse
P21520    512 KLPHDCSEvht---qtdGLHLIAPAgqr----hpLMTHCTAd----GWTTVQRRFDGSA---DFNR-SWADYAQGFGAPG 576 fruit fly
AAF55227  131 PAKSDCHEldeg-vrvdGVYRFLVPernevqrdlYERYCAFatdgpAWTVIQSRGGSFDpheNFNR-SWDEYRAGFGNLS 208 fruit fly
AAC64000   38 GLPADCSRltss--spsGVYVIQPAqs-----ppRVVWCDMdtegkGWTVVQRNTYSTEi--TWKE-SWTTYKYGFGDVQ 107 chicken
AAA81695  219 DASDNCLErlal-gspsGVYSIQSVe-------kFQAFCDMdtttgGWTVIQRRVDGDG---SFHRgTMKKFVEGFGNLQ 287 Caenorhabditis ele...

Feature 1                                                                                     
1FZG_F    133 ptgtTEFWLGNEKIHLISTqsaipYALRVELEDWn---------GRTSTADYAMFKVGpeADKYRLTYAYFaGGDAGDAF 203 human
NP_033771 364 ----REHWLGNEAVHRLTSrt--aYLLRVELHDWe---------GRQTSIQYENFQLGseRQRYSLSVNDS-SSSAGRKN 427 house mouse
AAK83349  316 ----KEFWLGLAKIHSIAQqg--eYILHIELEDWk---------EEKRFIEYTFTLEGp-ASDYALHLAPL-SGDLSDAM 378 zebrafish
AAD45920  311 ----GEFWLGLEKIYAIVQqs--nYILRLELQDWk---------DSKHYVEYSFHLGSh-ETNYTLHVAEI-AGNIPGAL 373 house mouse
NP_055310 311 ----GEFWLGLEKIYSIVKqs--nYVLRIELEDWk---------DNKHYIEYSFYLGNh-ETNYTLHLVAI-TGNVPNAI 373 human
AAC97965  257 ----GEFWLGLEKMHSITGnr--gSQLAVQLQDWd---------GNAKLLQFPIHLGGe-DTAYSLQLTEPtANELGATN 320 house mouse
P21520    577 ----GEFWIGNEQLHHLTLdn--cSRLQVQMQDIy---------DNVWVAEYKRFYISsrADGYRLHIAEY-SGNASDAL 640 fruit fly
AAF55227  209 ----RDFWFGNEFAHKILYrd--dHELRIELQEAg---------EPLDWAEYPLFWLDseSYNYQLSVAGEfRGSLPDAL 273 fruit fly
AAC64000  108 ----GDHWLGTEYLHLLTQqg--tYKVRFVVRDKa---------NVTHYAEYDIFRVEseSSGYPLRLGRL-LSSGKDYL 171 chicken
AAA81695  288 ----GSHWLGLEKLHNLAPigatpAILRIEIQGEtcdltcskrfANTWVGEWKVNFGKk-QDGYKIQITEEgVGNLTYNG 362 Caenorhabditis ele...

Feature 1                                # # #                                                
1FZG_F    204 DgfdfgddpsdkfftSHNGMQFSTWDNDNDKFeg---nCa-eQDGSGWWMN-KCHaGHLNGVYyqggtysk-astpngyd 277 human
NP_033771 428 Sl-------------APQGTKFSTKDMDNDNCmc---kCa-qMLSGGWWFD-ACGlSNLNGIYysvhq-------hlhki 482 house mouse
AAK83349  379 S--------------NHTGMKFSTKDRDNDNHde--snCa-rNYTGGWWFD-ACGdTNLNGRYaw-------------mr 427 zebrafish
AAD45920  374 P--------------EHTDLMFSTWNHRAKGQl----yCp-eSYSGGWWWNdICGeNNLNGKYnkprtk-----srperr 429 house mouse
NP_055310 374 P--------------ENKDLVFSTWDHKAKGHf----nCp-eGYSGGWWWHdECGeNNLNGKYnkprak-----skperr 429 human
AAC97965  321 Vs------------pNGLSLPFSTWDQDHDLRgd--lnCa-kSLSGGWWFG-TCShSNLNGQYfhsipr-----qrqerk 379 house mouse
P21520    641 N--------------YQQGMQFSAIDDDRDISqt---hCa-aNYEGGWWFS-HCQhANLNGRYn---------------- 685 fruit fly
AAF55227  274 E--------------QHNRMDFSTYDRRRNHAksadstCg-eDYGGGWWFD-RCTqCNLNGEHgvhq----------ras 327 fruit fly
AAC64000  172 Tsyys------syggIHDNMKFSTVDKDQDQHsg---nCa--SSYGGWWYD-RCQnVLLNGKKyilwpei---cprvtac 236 chicken
AAA81695  363 Vdp----------ffGANGRRFSTNDNDQDENtf--mnCaqfRMVGPWWHPkSCSdVGLNGYFqttsekydvkdrnqnak 430 Caenorhabditis ele...

Feature 1                                    
1FZG_F    278 NGIIWATWKTr------wYSMKKTTMKIIPF 302 human
NP_033771 483 NGIRWHYFRGp------sYSLHGTRMMLRPM 507 house mouse
AAK83349  428 SKARHQRRKGs------sYTLKSTKITIRPS 452 zebrafish
AAD45920  430 RGIYWRPQSRk------lYAIKSSKMMLQPT 454 house mouse
NP_055310 430 RGLSWKSQNGr------lYSIKSTKMLIHPT 454 human
AAC97965  380 KGIFWKTWKGr------yYPLQATTLLIQPM 404 house mouse
P21520    686 LGLTWFDAARne-----wIAVKSSRMLVKRL 711 fruit fly
AAF55227  328 PAIIWMNWRTg------tDKPKSSRMMIRPV 352 fruit fly
AAC64000  237 RPSSWSNPPMca-----dCARRWGSATIPSR 262 chicken
AAA81695  431 RYFVWAFDKQiyngypytIHVRKSTMLLKTG 461 Caenorhabditis elegans

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