6MZD,6MZL


Conserved Protein Domain Family
HFD_TAF13
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cd07978: HFD_TAF13 
histone-fold domain found in transcription initiation factor TFIID subunit 13 (TAF13) and similar proteins
TAF13, also called TATA Binding Protein (TBP) associated factor 13, transcription initiation factor TFIID 18 kDa subunit, TAF(II)18, TAFII-18, or TAFII18, is a component of the DNA-binding general RNA polymerase II transcription factor IID (TFIID) complex that is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs). TFIID is one of the general transcription factors required for accurate and regulated initiation by RNA polymerase II. It plays a central role in mediating promoter responses to various activators and repressors. TAF13 interacts with TBP, and more strongly with TAF10 and TAF11.
Links
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Statistics
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PSSM-Id: 467023
Aligned: 87 rows
Threshold Bit Score: 76.3451
Created: 1-Oct-2008
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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oligomer
Conserved site includes 30 residues -Click on image for an interactive view with Cn3D
Feature 1:oligomer interface [polypeptide binding site]
Evidence:
  • Structure:6MZD; Homo sapiens TAF13, a component of TFIID, interacts mainly with TAF11 within the complex; contacts at 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1         #  ## ########   ## ##  ## ############  #                                     
6MZD_S        31 LFSKELRCMMYGFGDdqnPYTESVDILEDLVIEFITEMTHKAMSIGrq-------------grVQVEDIVFLIRKDPRKF 97  human
ELQ75276      27 LYTNEIKAMLYSFGDsknPSLQTAQYLESVLKTQIQRFLSAANNIRicrr----------gklINLEDIGFVIRKDPFKL 96  Trachipleistoph...
XP_004365444  80 LFHHHIQQMMFAFGDakeTDKDAAYLIEEIVQREIQQIFVNAMNCAiqrq----------sryPTVQDVAIALSNDRSRM 149 Capsaspora owcz...
OAG31988      27 SYQSEIKSMMYACGDvrtPEKESSLYIEQIVYAQMKRLLEKSTEVSrlre----------skhTTIEDVVFVLRKHPCRV 96  Nematocida disp...
XP_018016608   2 SFISEIEQMLHGFGDcrrPLRETAALVETIVHQQITSLLHQAQEGSelrg----------sseVAVEDILFVMRHDHIKL 71  Hyalella azteca
XP_019858570   1 MFHSEISGMMHAFGDikqSNVESVQLVEEIIYQEITELISDSVKMVsrkn----------gksVLLSDILFIMRRDKQKL 70  Amphimedon quee...
OTF81793      86 SYMEEIRRMMHAFGDvrqPLIESARMIESIVRNQMTMLLLEAQRVAqmrysqslsmtnpprthISMEDFIFLLKHDRHRL 165 Euroglyphus maynei
RDD46790     108 SFTTEILAMMHAFGDvanPLYQSAILIEEIIRRQISNLLIKTSELTllrg----------akiMTVDDILLQFRKNKKKY 177 Trichoplax sp. H2
TBU03628       2 FYDTEIQSMMFTFGEvknTNHETIEYIESIIRSNIKSLLSKSRKVQilrk----------gkyLSVEDICFVLRRKVYMV 71  Hamiltosporidiu...
XP_013094664   7 WFTSEIQQMMYGLGDakkPLLETAVLVEEIVHQQMMAMIYQASEISisrg----------ekqISIEDILFLLRKDKAKL 76 

Feature 1               
6MZD_S        98 ARVKDLL 104 human
ELQ75276      97 RRLLNFI 103 Trachipleistophora hominis
XP_004365444 150 MRLHEYL 156 Capsaspora owczarzaki ATCC 30864
OAG31988      97 KKLSNYI 103 Nematocida displodere
XP_018016608  72 QRLLQYL 78  Hyalella azteca
XP_019858570  71 QAAVNYL 77  Amphimedon queenslandica
OTF81793     166 AKLIRYL 172 Euroglyphus maynei
RDD46790     178 KHILKIL 184 Trichoplax sp. H2
TBU03628      72 NRILQFL 78  Hamiltosporidium tvaerminnensis
XP_013094664  77 KRILKYY 83

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