3K9V,3N9Y,4DVQ,4ZGX


Conserved Protein Domain Family
CYP24A1-like

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cd11054: CYP24A1-like 
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cytochrome P450 family 24 subfamily A, polypeptide 1 and similar cytochrome P450s
This family is composed of vertebrate cytochrome P450 24A1 (CYP24A1) and similar proteins including several Drosophila proteins such as CYP315A1 (also called protein shadow) and CYP314A1 (also called ecdysone 20-monooxygenase), and vertebrate CYP11 and CYP27 subfamilies. Both CYP314A1 and CYP315A1, which has ecdysteroid C2-hydroxylase activity, are involved in the metabolism of insect hormones. CYP24A1 and CYP27B1 have roles in calcium homeostasis and metabolism, and the regulation of vitamin D. CYP24A1 catabolizes calcitriol (1,25(OH)2D), the physiologically active vitamin D hormone, by catalyzing its hydroxylation, while CYP27B1 is a calcidiol 1-monooxygenase that coverts 25-hydroxyvitamin D3 to calcitriol. The CYP24A1-like family belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Statistics
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PSSM-Id: 410677
Aligned: 148 rows
Threshold Bit Score: 342.969
Created: 3-Apr-2007
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
 
heme bindingchemical
Conserved site includes 26 residues -Click on image for an interactive view with Cn3D
Feature 1:heme binding site [chemical binding site]
Evidence:
  • Structure:4DVQ: Human CYP11B2 binds heme; contacts at 4A
  • Structure:3K9V: Rattus norvegicus CYP24A1 binds heme; contacts at 4A
  • Structure:3N9Y: Human CYP11A1 binds heme; contacts at 4A

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                #                      ##         #   #  
3K9V_A         58 HKKYGQIFRMKlg-sfDSVHLGsPSLLEALYRtESAHPQRle-iKPWKAYRDHRNea---yGLMILEGQE---WQRVRSA 129  Norway rat
4DVQ_A         46 FQELGPIFRYNlg-gpRMVCVMlPEDVEKLQQvDSLHPCRmi-lEPWVAYRQHRGhk---cGVFLLNGPE---WRFNRLR 117  human
Q9VUF8         97 NRQYGDIVLEVmpsnvPIVHLYnRDDLEKVLKyPSKYPFRpp-tEIIVMYRQSRPdryasvGIVNEQGPM---WQRLRSS 172  fruit fly
EEB18195      163 FKKYGPIVKLQgplgaDIVIINkPEHVGKVYDqEGKHPVRft-lDSVEKCRAVFRkn--sgGPFSLYGVE---WEEMRKA 236  human body louse
EEB20140     2125 FNKYGPIVNLQgplsgNIILLHkPEHLSAVFE-QDSLPFIrsvlDSLELSRQEAEek---iSIALPTDWNtpeWNHLRKL 2200 human body louse
EFX77008       93 YRKYGPVVKEHflwnfPIIHLYdKHDIESVLKyPSKYPIRpg-lEAQIFYRKSRPdryksaGMVNVQGFE---WQHLRSK 168  common water ...
BAV93930       55 YFRYGKICKEEfvwgrPLIQVFdPDDIEKVLRnQGKFPLRpq-nEAAVMFRKSRPelyssvGLVNSAGEE---WHRLRSG 130  Chamberlinius...
BAR80872       80 YCRYGDLMKEEyqwrsPVVHAFnPNDFETVFRhQGRCPVRpp-nAFVSKYRRERAdrydsvGLSNALGEE---WYKLRSA 155  Ornithodoros ...
AIL94172       82 YSTFGPVVREEvlfnfPLIHLFdKSDIQHVLRnESEYPMRpp-nEADVFYRRLRHdiylndGMVNLNGPQ---WHTLRSL 157  Tigriopus jap...
XP_003748577   64 LLKYGPICKEEyqyrrPVVHLFhAESFPALFRsQGSCPIRpp-nEFVCKYRREHPekysgvGLSNALGEE---WRSMRLA 139  western preda...
Feature 1                                                                                         
3K9V_A        130 FQKKLMKPVEIm--kLDKKINEVLADFLERMDELCDergr---ipdlYSELNKWSFESICLVLYEKRFGLlqke------ 198  Norway rat
4DVQ_A        118 LNPDVLSPKAVq--rFLPMVDAVARDFSQALKKKVLqnargsltldvQPSIFHYTIEASNLALFGERLGLvghs------ 189  human
Q9VUF8        173 LTSSITSPRVLq--nFLPALNAVCDDFIELLRARRDpdtlv--vpnfEELANLMGLEAVCTLMLGRRMGFlaidt----k 244  fruit fly
EEB18195      237 LNEPLAKGGER----YFGAIDEAGDMFVRRIGAIKNkqsev--ppdfLVEITKWSLECLCFVALGKSLGFhnpdanstse 310  human body louse
EEB20140     2201 TADSMILEYDK----FFEFVDLAGDSLISVIKHCKNgqntv--sddfMEEIKRWSLDGLSRVLFTKSLSLsesknwn-sn 2273 human body louse
EFX77008      169 LTTQLASTALGd--hTIAQLCIISDELIEKIQEERVeniv----dgfEKVIYRCGLEVIFAILFGRRLGAlnkns----- 237  common water ...
BAV93930      131 LVGFIVKPGVVt--dFAIHQNAICDDLIQLLVDSSHsdgi---vdnvMEAFHRMALESTTMFCLETRMGClkgdi----e 201  Chamberlinius...
BAR80872      156 LAPVLLQMKNVq--tLCSQQERISEHFAMYLKGLRNpedds--idniQDPLYRFTLESIFMLCLNSRLGClsen------ 225  Ornithodoros ...
AIL94172      158 LTPPLTNRNTLr--sYCTQMNTIANDLMEHIEAESDnedgi--ikdlKDLVYRTGLETVATVSLDRRMGFlqke------ 227  Tigriopus jap...
XP_003748577  140 LAPVLRQMSAIhtkdMLDIQTEICDDWVRHLQESAQdgvv----adiQELLYMLALESIFALCLEKRLGCfeg------- 208  western preda...
Feature 1                                                                                         
3K9V_A        199 teeeALTFITAIKTMMSTFGKmmvtpve--lhkrlntKVWQAHTLAWDTIFKSVKPCIDNRlqrys-------------- 262  Norway rat
4DVQ_A        190 pssaSLNFLHALEVMFKSTVQlmfmprs--lsrwispKVWKEHFEAWDCIFQYGDNCIQKIyqelaf------------- 254  human
Q9VUF8        245 qpqkISQLAAAVKQLFISQRDsyyglgl---wkyfptKTYRDFARAEDLIYDVISEIIDHEleelkksaa---------- 311  fruit fly
EEB18195      311 plrlLKSLIDATHNICKCESGfqlwr-------fmntPASVGLTQSCEIIDSFISKYVRLAqvnltrnktdi-------i 376  human body louse
EEB20140     2274 tlyePDKLFNAVQEASNYLTKcekgfqp---wrimvtPSLVGLGQAYRTLSTILSKQLYQAemslkhkndvliksggqts 2350 human body louse
EFX77008      238 ippiAERLMFATENLFEVSHEtmyglpw---wklfptKSYKKLAECEDTIYDVFTDLVNEAlsnde-------------- 300  common water ...
BAV93930      202 egseAKKMIDASLDLFQAYQSlyygppl---wkyfttSAYKKMSDSETTLYQIVTKYIAEAksreqd------------- 265  Chamberlinius...
BAR80872      226 gtkdAATVIAAAKSLFGAYQRlyyglpl---wkyfntPAFREYQETEDTLYDVTLRYLEECgqqtsp------------- 289  Ornithodoros ...
AIL94172      228 mnaeTLLILQSIKGYQTSSNEamyglpwwkyvptrfsGVLTNLVFHKDNLFSVVGKIVDEVltdernng----------- 296  Tigriopus jap...
XP_003748577  209 -nprAREMVQATKDLFECYQKlyygspl---wkkvptKPYLDFCKAEETVYRITEDFLREAsat---------------- 268  western preda...
Feature 1                                           #  ##  ##  #                                  
3K9V_A        263 -----qqpgADFLCDIYQQDhl-sKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQAQRRLLqevqsvlpdnq-tpr 335  Norway rat
4DVQ_A        255 ---nrpqhyTGIVAELLLKAel-sLEAIKANSMELTAGSVDTTAFPLLMTLFELARNPDVQQILRqeslaaaasis-ehp 329  human
Q9VUF8        312 ceddeaaglRSIFLNILELKdl-dIRDKKSAIIDFIAAGIETLANTLLFVLSSVTGDPGAMPRILsefceyrdtn---il 387  fruit fly
EEB18195      377 mnrektetnLSFIENLLLNEcl-sPDEVLTCIVDLLLLGVNTTSSALAFFLYHLAQNQRSQRTLFkeikeflpekhsrle 455  human body louse
EEB20140     2351 nsnnnnnseLTLIENMLLFDgm-tSEEITCNLIDILILGSGVASSALGFLLYHLAQNVKAQQKLSkegkeilpekttkln 2429 human body louse
EFX77008      301 ----nteiqSPVLNQILTAEgv-dIRDKIVALIDLVAAGIETTGNATLFLLHNIVSNPEVKARVYeeldrvlysshvtit 375  common water ...
BAV93930      266 ----fdpeaSTSMSQLLINAkdidPRDIKAGIVDLITAGIDTTANALVFALNQLSLNPKVQDKLFqeidgligkr--eat 339  Chamberlinius...
BAR80872      290 ---qaddgeKTLLQALLAAPgl-sKKDRHLTIMDFIAGGVFTATNALCILLHHLACNPSTQEKLYtelkavd-------- 357  Ornithodoros ...
AIL94172      297 --ssygdneNSILKQLLTNPql-dIKDVKVSLVDYITAGVDTIGNSIIFAISLIAKHPKVQARLQqeldeylrpge-dlt 372  Tigriopus jap...
XP_003748577  269 ------esqSRVLRALTTLPnf-dWKDVQLTAMDFIVGGVFTITQSMAFLIHQIAINKRVQDKLVrtlrna--------- 332  western preda...
Feature 1                          #    ##  # #                                                   
3K9V_A        336 aedlrnmPYLKACLKESMRLTPSVPFTTRTLDKPTVLG-EYALPKGTVLTLNTQVLGSSEDNFEDSHKFRPERWLQkek- 413  Norway rat
4DVQ_A        330 qkattelPLLRAALKETLRLYPVGLFLERVVSSDLVLQ-NYHIPAGTLVQVFLYSLGRNAALFPRPERYNPQRWLDirg- 407  human
Q9VUF8        388 qdaltnaTYTKACIQESYRLRPTAFCLARILEEDMELS-GYSLNAGTVVLCQNMIACHKDSNFQGAKQFTPERWIDpate 466  fruit fly
EEB18195      456 yktlnnfKYLDACLKESLRLKLPMPTLTRVLPTDIALS-NFRIPKGTYMVMDIQSACLKEQNFEKSDKFIPERWFEptn- 533  human body louse
EEB20140     2430 iqklhsmKYMQACIKESMRLNTPYPLFFRLLQNDIFIS-NYIVPKGTYVVMDSRVFGMREQFFEEPDKFIPERWLNddkw 2508 human body louse
EFX77008      376 pqlllelKYLKACVTESLRLTPVAPNVARILEKSFTFQ-GYNVPVGAMVICETWVSSLQDENYPDAKRFIPERWLDadkv 454  common water ...
BAV93930      340 aadlsslPYLKACVKESFRISPTIPNIVRILTDDLVLS-GYLIPKGTVIICQTMVSSMLNDFVDKADEFLPERWLPgypk 418  Chamberlinius...
BAR80872      358 -wkamqcSYLRACIKESFRLSPTVPGVMRILPEAVTLS-GYNVPAGVPIFANFLVPCSLEKYFPAPSVFRPERWLGperm 435  Ornithodoros ...
AIL94172      373 aekinslKYLKACVTESFRMYPTASQIARILPQDTEVTgGYVLPKHSVVLCHQRLASWQDENFTEAQKFAPERWIEnael 452  Tigriopus jap...
XP_003748577  333 -pipatdPYLKACMKETFRISPTVPGVMRVLPEDTVLC-DYHVPAGTAVFANSLIACRNEETFHRASEFIPERWLDgrp- 409  western preda...
Feature 1                      ####  #####   #                                                    
3K9V_A        414 ---kinPFAH--LPFGIGKRMCIGRRLAELQLHLALCWIIQKYDIva-----tDNEPVEMLh-------lGILVPSRELP 476  Norway rat
4DVQ_A        408 ---sgrNFHH--VPFGFGMRQCLGRRLAEAEMLLLLHHVLKHFLVet-----lTQEDIKMVy-------sFILRPGTSPL 470  human
Q9VUF8        467 nftvnvDNASivVPFGVGRRSCPGKRFVEMEVVLLLAKMVLAFDVs-------FVKPLETEf-------eFLLAPKTPLS 532  fruit fly
EEB18195      534 ----iqSFSF--IPFGYGIRSCVGKHLAEVQLKSCIAKIIRNYQIe------yNYGEIHGTk-------tVISFPDVPLK 594  human body louse
EEB20140     2509 m-qnahAFSS--FPLCHGPKSDLIKRIIEMQLCACVAKARYQLKMsvkkktiiRNFEIEYHfgeivgtenFISFPEKPLK 2585 human body louse
EFX77008      455 ---nhhPFLA--VPFGVGRRMCPGKRIAEHEMLIITAKLLQTFDMs-------FQKPLEQVy-------kFLISPKGPIR 515  common water ...
BAV93930      419 ---rcsNYTV--QPFGCGPRMCPGRRFAEQEIYLMLIKLIQKFRIe-------YVKELERQy-------lFIITPKSPVT 479  Chamberlinius...
BAR80872      436 ---aihPFIM--LPFGHGARMCAGRRFAELELMTATAKVVEHFVLep----vtKVLELNYI---------FVMAPSHPVG 497  Ornithodoros ...
AIL94172      453 dfpvceRGLV--IPFGIGKRICPGKRLAEQEVHVIVAKMFQKFSVs-------LVDEFDVEf-------nFLLTPSGSVP 516  Tigriopus jap...
XP_003748577  410 ----qfPFAL--LPFGFGARMCPGRHFAELEMCSAVASLLKKFEIs------sPMEQIPVKc-------iFVIAPEGEVP 470  western preda...

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