5GIN,5ZWO


Conserved Protein Domain Family
Nop

?
pfam01798: Nop 
snoRNA binding domain, fibrillarin
This family consists of various Pre RNA processing ribonucleoproteins. The function of the aligned region is unknown however it may be a common RNA or snoRNA or Nop1p binding domain. Nop5p (Nop58p) from yeast is the protein component of a ribonucleoprotein required for pre-18s rRNA processing and is suggested to function with Nop1p in a snoRNA complex. Nop56p and Nop5p interact with Nop1p and are required for ribosome biogenesis. Prp31p is required for pre-mRNA splicing in S. cerevisiae. Fibrillarin, or Nop, is the catalytic subunit responsible for the methyl transfer reaction of the site-specific 2'-O-methylation of ribosomal and spliceosomal RNA.
Statistics
?
PSSM-Id: 460335
Aligned: 304 rows
Threshold Bit Score: 174.952
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
?
Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
5GIN_B       147 MDDIDKTINLFSERLREWYSIHFPELDKLIEDHEEYATIV-SRFG-------DRGFLTIDslk------elgFNEQ---- 208 Saccharolobus s...
XP_001327582  34 llkLRKQ---LHSILTNTFHERFADLASVVTDYKPYAILAkHLATh------NEIESEDIrk-----------------f 87 
Q5CQM4       110 VGIIDSKVSEKYECVKALYKDHFGELASIIINKIDYLEVVkRIIThenfedvKLNDI----------------------- 166 Cryptosporidium...
EEA06551      73 LGNIDKIIEILHKNVINLYRPKFGELSSIIINPIQYLEVVkRCIHvsditqvQFNDI----------------------- 129
CBX92866     108 STQIDGEIATVHKYIRDNYSVVFPYLEELVKNPVDYAKTV-AILQn------GPLD--DIktiaqrtdnivgTALKn--i 176
Q0UMN0       114 STQIDGEIQAVHKFIRDRYSARFPYLEELVKNPVDYAATV-AVLGn------RSLK--EIktiaqspdnvvgIALNt--i 182 Parastagonospor...
XP_008030573 106 STQIDGEIAAVHKFIRDHYSAFFPHLEDLIKNPVVYARAC-LVIGg------GPLK--DIkt--------itPQLKaieg 168
CCH42402     121 SVEITNEIFLVHDFIKAHYRRRFPELESLIPNSFEYSKIV-KTLGnnldis---------------qdelsfISKEk--v 182
Q6CER2       111 SVEIDNAVAELHNFIATRYSQRYPELRSLIANPLQHAQVV-AILGn------DPAAVAKSds----------phLKq--v 171 Yarrowia lipoly...
XP_007874097 125 AVEIDNEIITINKFIRDNYSQRFPELESLVVNPLDYAKTV-RIIGn------Q-MDITQVn-------------Ls---h 180
5GIN_B       209 RINRILDAAKK----SIGADISEDDLSAMRMIANTILDLYNIRRNLNNYLEGVMKEVAPNVTALVGPALGARLLSIAGSL 284 Saccharolobus s...
XP_001327582  88 LTSQQIVACTLslqqQLGPEI---ESKDFQEACDLQIAASDVSTQLSEICTKCVEMFAPNMCALVGPEISAILITHAGGL 164
Q5CQM4       167 LPNSTIMTITIssstSKRNIPTLEKKESILKCIDFVNQINESKSKILEFLQFQIEAITPNLSALIGPEIAANLLCVSGGL 246 Cryptosporidium...
EEA06551     130 LPNSIAMTISIaastNTNANISNDTCINIENLIDDAFSLFKKKNELLKFVELEMDKIAPNLSSLVNPNLAAMLICSTNGL 209
CBX92866     177 LDGPSLMVITVeatrAQGRKLKEAELEAVVGACKLLLDLDKAKSTLTQFVQSRMRVFAPNLTTLLGSLAAAQLINHAGGL 256
Q0UMN0       183 LPAPTLMVISVeatrAEGRDLDENELEIVVDACKLLLQLNKTKDTFRDFVQSRMTIFAPNLTALVGSLTAAQLINHAGGI 262 Parastagonospor...
XP_008030573 169 LEPAQVMIVEIeatrVEGRLLDEAELSLISNACHLLLELNAAKSKILGFVESRTEVFCPNLTALIGSLTAAHLISYAGGI 248
CCH42402     183 L----VLTMSViqakDNTQELSPSDLQKVIAACDLLLELDSSRREITEYVASRLSVFAPNLAAIVGSYTASQFMSVLGGL 258
Q6CER2       172 VHKSVMMTITMtv-dQGGRRLSDVEMATINEACKLLIALDAAKRQITNYVSSKLNLVAPNTAILIGAHCAAQILGFVGGL 250 Yarrowia lipoly...
XP_007874097 181 LPSATVMVITVtnstSEGTLLQQNKLDMVFEACDLTLELESAKKKILEYVQSRMNLIAPNLLAIVGSTTAAKLISVAGGL 260
5GIN_B       285 DELAKMPASTIQVLGAEKalFrALRsGG--R--PPKHG--------------IIFQYPAIHtS-PRWQRGKIARALAAKL 345 Saccharolobus s...
XP_001327582 165 KQLSQIPSCNIKTFGSNK----SALlGFssRniGNHQG--------------IIYTSELVQ-QtDPEYRDSIFRNLADKV 225
Q5CQM4       247 KNLAEMPSQNIMVLGSLKn--------------NKKNGhfstgpvrlellqsIISQSDIVR-NiQDKYKKKAIRLVSLKC 311 Cryptosporidium...
EEA06551     210 RNLAEMPSQNIMLLGSDRk--------------SRKYGlyttgvlrielqqsYLSKCDIVL-GvPELFKKKALRLLSSKC 274
CBX92866     257 QGLAKTPACNIAPLGSNK--AtG-L-GLatNigIRHQG--------------YIYHSPLLQ-TiREDLKKQALRIVSAKV 317
Q0UMN0       263 HGLAKTPACNIAPLGQNK--AsG-L-GLatNtgVRNQG--------------FLYHSPLLQ-TiRQDLKKQAMRILSGKV 323 Parastagonospor...
XP_008030573 249 SNLAKTPACNIAPLGSTK--VsGAT-VGlsNigLRHEG--------------YLYHSEIIQ-NqRPDLRKQALRIVSAKV 310
CCH42402     259 KGLSQTPSCNIPSLGNKR--AvG-I-GFgqSg-VRQQG--------------ILFYSDLIQ-SvDPDIRKQAMRIVSGKI 318
Q6CER2       251 NGLAKTPSCNIPSLGAKR----ETAvGFgqA--QRQQG--------------YLYYSDVVQ-QsPADIRKQAMRMLSAKL 309 Yarrowia lipoly...
XP_007874097 261 AGLVRMPGCNISALGAKR--Q-SQT-GFssTigIRHQG--------------FLFHSEILQ-KvPPDLRKQALRIISSKI 321
5GIN_B       346 AIAARVD---AFS-GRFIGD-QLNEQLKKRI 371 Saccharolobus solfataricus
XP_001327582 226 ALCCRVDa--SKGnPDGSFGeKSLFEIKEKL 254
Q5CQM4       312 GLCARIDf--SSTdKSPDHGvNYRNYILNIL 340 Cryptosporidium parvum
EEA06551     275 SLCARLDl--AKSnKDGKYGkNWRDYIIKIL 303
CBX92866     318 ILAARIDmvhQS--TDGSMGqQLKDECERRL 346
Q0UMN0       324 ILAARVDsvgQS--RNAETGnQLKDECEKRL 352 Parastagonospora nodorum SN15
XP_008030573 311 ILAARVDahsSS--RNADIGmDLRKECERRL 339
CCH42402     319 ILAARMDfasSV--PDGSRGqKWRREIDEKI 347
Q6CER2       310 VLAARLDa--SRAsTDGSFGsKMREEIEGKL 338 Yarrowia lipolytica
XP_007874097 322 ALASRVDrlhQS--PDGSIGaSLREYIEKRL 350
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap