Conserved Protein Domain Family
7tmA_OR14-like

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cd15227: 7tmA_OR14-like 
olfactory receptor family 14 and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor family 14 and related proteins in other mammals, sauropsids, and amphibians. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320355
Aligned: 135 rows
Threshold Bit Score: 364.082
Created: 4-Dec-2013
Updated: 17-Oct-2022
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q96R54        23 ILYGVLFLLIYLAALMSNLLIITLITLDVKLqtPMYFFLKNLSFLDVFLVSVPIPKFIVNNlthnNSISIlGCAFQLLLM 102 human
XP_007442426  23 ILYFTLFLVIYLAALIANLLIISAVSFHRHLhtPMYFFLVNLSVVDLGSISVTIPKAMMNSflntREISYaGCIAQVFSL 102 Burmese python
XP_007442269  23 IVHFVTFLAIYLVALMGNFLIITVISLNTHLhtPMYFFLVNLSIADLGAISVTIPKTMTHT----RTISYiGCAAQVFFL 98  Burmese python
XP_007444800  23 MVHILIFLIIYLMALIENLIIITVIVCSHQLhsPMYFFLANLSFQDLGSISVTVPKSMLNSlmntETISYpGCLSQVFFF 102 Burmese python
XP_003224624  23 ILSFFVFLAFYLTALIGNLLIITVVAVDSHLhtPMYYLLFNLAMLDIGSISVMVPKAMAMSlkndRSITYaGCVAQVFFY 102 green anole
XP_007442424  18 TFYFLVFFVIYTASVIGNLLIIIIVILNIHLhtPMYFFLLNLSVIDLGYISVIIPKVMANSlrrtRIILFsHCAAQMFSS 97  Burmese python
XP_007442283  23 ILYFLALSIIYLTSLTGNFLVIVAVALNNTLhtPMYFFLANLSTIDLGYISVTIPKAIANLlmatWQISYpECVAQVFFF 102 Burmese python
XP_003224576  24 PFHFLAFLFIYLMAVIENLFIITVIIKSHHLhkPMYFFMANLAFQDLGSISVTVPKSMENSlkkiNTISYsGCICQVFFL 103 green anole
XP_007442284  23 ILYFVILFLIYLAAMVGNLLIIIVVVLDHHLqaPMYFFLVNLSVTDLGYISVTILKAMVNSlkktTRISYrGCVAQTFFL 102 Burmese python
XP_007444108  23 ILTFGGFLLIYLAALIGNLLMITVVTLNPHLqtPMYFFLVNLNIVDLSFISVTVPKAMANSvmntKRISYyGCMAQVFFF 102 Burmese python
Feature 1        #  #                                            # #####                         
Q96R54       103 TSFSAGEIFILTAMSYDRYVAICCPLNYEVIMnTGVCVLMASVSWAIGGLFGTAYTAgtFSMPFCGSSVIPQFFCDVPSL 182 human
XP_007442426 103 FFFLISDLFLLTAMAYDRYIAICDPLHYETIMdMNACLQLAAIAWITGLLYSALHTCs-TFAVTFCSNVLNQFFCEIPQL 181 Burmese python
XP_007442269  99 IFFMAVDVSLLTVMAYDRFVAICDPLHYVIVMsRASCVQMAVIVWVSGLLYGSVHVGg-TFSITFCSNVVNQFFCEIPQL 177 Burmese python
XP_007444800 103 VFFVMSHFFLLVVMAYDRYVAICNPLHYEMIMnKKTCIQMVTSAWMAGLFYTTLYTGn-LFMVKFCSRIINQFFCEIPQL 181 Burmese python
XP_003224624 103 IFFGASGYSVLTIMAHDRYVAICHPLHYERIMhKGACLQMVATGLIASLIYAILHTGc-TFANTFCSNIVNQFFCEIPQL 181 green anole
XP_007442424  98 VVFAASEILLLTVMAYDRFVAICHPLQYETIMdRSRCIQLASYAWMMGIVIATLHTSa-TFASPFCSNVIHQLFCEIPQL 176 Burmese python
XP_007442283 103 TLFGNSEFFLLTIMAYDRYVAICNPLQYESLLnKKACIQMVTSMWAVSLFYAVLHSSc-TFAITFCSNLINQFFCEIPSL 181 Burmese python
XP_003224576 104 LFFTISHFYLLGIMAYDRYIAICNPLKYETIMnKKACIHMAMSTWICGFGLSSLYTGs-LFTVSFCSNDVNQFFCEIPQL 182 green anole
XP_007442284 103 LLFGGSELFLLTMMAYDRYVAICNPLNYVKEMnRGMCVKMATSAWIFGLLDAVLNTAc-TFTITFCSNNINQFFCEIPQL 181 Burmese python
XP_007444108 103 FWAGTSEFLLLALMAYDRYVAICNPLNYVKEMnREACLKMATSAWIFGFFDASLNTAc-TFTVTFCFNKINQFFCEIPQL 181 Burmese python
Feature 1                   #  ### ### ##                                            #  ## ##  # 
Q96R54       183 LRISCset-lmVIYAGIGVGACLSISCFICIVISYIYIFSTVLKIPttKGQSKAFSTCFPHLTVFTVFIITAYFVYLKPp 261 human
XP_007442426 182 LKVSCdns-ylIEVGVILLSACIVFACFGFIIVSYVQIFKSVLRIPssQGRNKAFSTCFPHLLVVSLFISTGSIAYLKPt 260 Burmese python
XP_007442269 178 LRLSCsnl-ylMEVGILVLGACLVFSCFVFITISYVQIFRAVMKIPsmKGRQKAFSTCLPHLIVVSLFICICAFAYLKPi 256 Burmese python
XP_007444800 182 LKISCsds-yfVEVWALIFGSCLAFIQFALIAFSYVQIFRAVFKIPstQGKQKAFSTCLPHLIVICLFVVSGTLAYLCPt 260 Burmese python
XP_003224624 182 IKLSCsgl-slMETGVLILSFSIALGCLIFIIRSYVQVFVVVLRIPssQGQKKALSTCVPHLTVVTMFVASGVLAYARSi 260 green anole
XP_007442424 177 LRLSCsdt-yhIEIGAIALTTVLYVACFVFIVISYTQIFKAVVRIPseQGRQKAFSTCLPHLIVLSMLYFFGMFAYLRPi 255 Burmese python
XP_007442283 182 LQLSCsds-yiLEDRMMSLAMLFVVGCFSFIIISYLKIFKAVLKIPsaKARKKATSTCFPHLFVLFLFFFTGGIAYLGPs 260 Burmese python
XP_003224576 183 LKISCsdt-ylIAFYVICAGSSISFIYISLIISSYIEIFRAVLKITstQRKPKAFSTCLPHLIVIVLYIISGSLVYLRPm 261 green anole
XP_007442284 182 LKLSClnssylAEIGALIFTVLICLSCFCFTVMSYVQIFRAVFTIPsvQGQKKAFATCLPHLLVLSLFYFTGMYTYLSSg 261 Burmese python
XP_007444108 182 LKLSCssssylVELGALVFTVLICVCCFSCTVVSYVYIFRAVFIIPsaQGKKKAVSTCLPHLAVLCLFYFTGVYACLGTt 261 Burmese python
Feature 1            ## ###  #  ##              
Q96R54       262 snsPSVIDRLLSVIYTVMPPVFNPVTYSLRN 292 human
XP_007442426 261 sdsPSDVDVVITVLYSVIPPLMNPIIYTMRN 291 Burmese python
XP_007442269 257 srpPSDFDLVAAVIYCSVPFMMNPIIYSIRN 287 Burmese python
XP_007444800 261 stsSSALDPFLSIFYCVIPPLMNPLIYSMRN 291 Burmese python
XP_003224624 261 a-dSSNLDTVLAMIYTIIPPMSNPFIYSVRN 290 green anole
XP_007442424 256 nriPSQMDLVATIGYCIVPPFMNPVIYSMRN 286 Burmese python
XP_007442283 261 stiSGKMGLVLSVMYSVIPPFMNPIIYSIRN 291 Burmese python
XP_003224576 262 srsLSTMDLVLSVFYCMLPPLMNPLIYSIRN 292 green anole
XP_007442284 262 fkfSSGLNVPLAMMYSVVPPFTNPIIYSMRN 292 Burmese python
XP_007444108 262 fraSSGLDLLLAVLYSMVPPFMNPIIYSMRN 292 Burmese python

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