Conserved Protein Domain Family
NT-C2

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pfam10358: NT-C2 
N-terminal C2 in EEIG1 and EHBP1 proteins
This version of the C2 domain was initally identified in the vertebrate estrogen early-induced gene 1 (EEIG1), and its Drosophila ortholog required for uptake of dsRNA via the endocytotic machinery to induce RNAi silencing. It is also in C.elegans ortholog Sym-3 (SYnthetic lethal with Mec-3) and the mammalian protein EHBP1 (EH domain Binding Protein-1) that regulates endocytotic recycling and two plant proteins, RPG that regulates Rhizobium-directed polar growth and PMI1 (Plastid Movement Impaired 1) that is essential for intracellular movement of chloroplasts in response to blue light.
Statistics
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PSSM-Id: 463058
Aligned: 55 rows
Threshold Bit Score: 57.33
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
XP_002552492   11 RRPKFLFNLKINELTNIPQ--SSGYCFVKW-HLKDGTgttshtiipeigspqsnvksssqsrGATPRVLVKSHRAHWNYS 87  
XP_001308543    4 PSYFIFYVQKIEYPRMIYS--QYTLTYITVeLQKVTLgikhs----------------sekvRSKTATLDNANCGVFECE 65  
XP_001324177    7 QSLKCYCILHIESIKFEKD--IKFPVFIRVaRVRKSGiferv----------------afnsETNYSMLDANLVAQFDCE 68  
XP_001326174    5 QVMNYIAFILVEKVQFPEK--YNKPLFIRVqRKKTAGgqtkl----------------afssETSYKNLDNNLIAHFDNE 66  
EAX99489        7 KSTPHHCFILIEKITFSKK--VDVPVFIRVaRKKSSGgvfkt----------------ayssETSFQLADQSNIVQFNNE 68  
XP_001308733    7 KSTPHFSFILIEKVAFTKK--VDVPVFVRVeRKKSSAgvmkk----------------afnsETKFQLADSNNIVQFNNE 68  
XP_654032       7 NIIKYTFTVEIKRVIGVKKy-QGHTLFIKW-WRGSKSk-----------------------sGVLKRSLVKEDEALWNSS 61  
Q54CQ9          8 DVLKVKVEILVKKVGNLKEl-NGGSVFVYW-RRGTSKq-----------------------sGETHHMIVRNGEAIFEEK 62   Dictyostelium...
XP_002871949   76 RRFNCCFSAQVHSIEGLPPifQDLSLTVHW-KRRDEs-------------------------LSTRPAKVSNGRAEFKDK 129 
Q9C8E6        137 QKLSCLLSVEVVAAQNLPAsmNGLRLGVCV-RKKETKdg----------------------aVQTMPCRVSQGSADFEET 193  thale cress
XP_002552492   88 LQKPVQVKLVt---DKNK----NLNSKEMVLEVYFEFleptnashgkfqhsrqlsdasstnssasssnsnvyTQKVsrkM 160 
XP_001308543   66 -----ACFN-----NPKQ----DNKQKLIHIVIGAVQd----------------------------------SEI----- 92  
XP_001324177   69 FIIPITLYQ-----KEGH----KLEKKILDIEIFSLDk---------------------------------nQGQN---- 102 
XP_001326174   67 FSLPFTTV------KKGD----KYVKKVVEIQLVSVSn---------------------------------kKKEE---V 100 
EAX99489       69 FQIPITIFT-----KKGE----EPQKKMLEVSCLAIMs---------------------------------kKEPE---H 103 
XP_001308733   69 FQIPVTIFT-----KKGE----KPQKKVVEITCLSVAs---------------------------------kKEPE---K 103 
XP_654032      62 FTFDTKLQPR----GNDG-----FKPKQLVLSIYVVk-----------------------------------TSSEi--- 94  
Q54CQ9         63 ISFESKFFID----AKSQ-----KPDEKKLSLQLKEe----------------------------------kKKSQg--K 97   Dictyostelium...
XP_002871949  130 LTHTCSVYGSrsgpHHSA----KYEAKHFLLYVAQVg-----------------------------------SPEI---- 166 
Q9C8E6        194 LFIKCHVYYSpa-nG--KgspaKFEARPFLFYLFAVd-----------------------------------AKEL---- 231  thale cress
XP_002552492  161 LLGVVEVNIAEYVNRE--------QHMVTSRFLLQKS--KVNSILSLGIQLELTRGSF 208 
XP_001308543   93 EIGSIDLDLEDIDK----------HKSKLAIKKIRFGk-HQKGKLYYRAIVLPITFFP 139 
XP_001324177  103 CISKVRMDIANLTDP---------RSTARQTSNFQTNk-FGTAQLNFRLCVLPIDEFP 150 
XP_001326174  101 EICKWRFDASNMPD----------PRDPSVHFSVASSd-FGNVNLYVRFCVIPAEEFS 147 
EAX99489      104 QVCTWKFDAANLLD----------PKDSSVQTSMTKCe-FGIATLYLRIVVLPESDFP 150 
XP_001308733  104 VVCTWKFDLANLAD----------PKDSSVQTSQTKCd-FGIATLYIRIVLIPETDYP 150 
XP_654032      95 LIGRVKLDLAQYIDMNd-------KIITFPFTEGECK--KGQVEACLFSAEKGSTISI 143 
Q54CQ9         98 VLGKIELDLTSYMNSKh------nQPITLSFTKGLKP--EPQIFCSFNTIPLKHNNKP 147  Dictyostelium discoideum AX4
XP_002871949  167 DLGKHRMDLTKLLPLTleel-qdeKSSGKWSTTFQLTgkANGATLSMSFGYTVVGDTR 223 
Q9C8E6        232 EFGRHVVDLSELIQESvekmnyegARVRQWDMNWGLSgkAKGGELALKLGFQIMEKdg 289  thale cress
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