4ZR0


Conserved Protein Domain Family
FA_hydroxylase
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pfam04116: FA_hydroxylase 
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Fatty acid hydroxylase
This entry includes fatty acid and carotene hydroxylases and sterol desaturases. Beta-carotene hydroxylase is involved in zeaxanthin synthesis by hydroxylating beta-carotene, but the enzyme may be involved in other pathways. This family includes C-5 sterol desaturase and C-4 sterol methyl oxidase. Members of this family are involved in cholesterol biosynthesis and biosynthesis a plant cuticular wax. These enzymes contain two copies of a HXHH motif which coordinate two irons at the catalytic centre. Members of this family are ER integral membrane proteins that share a novel mushroom-shaped fold consisting of four transmembrane (TM1-TM4) helices that anchor them to the membrane capped by a cytosolic domain containing the unique histidine- coordinating di metal centre.
Links
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Statistics
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PSSM-Id: 397991
Aligned: 110 rows
Threshold Bit Score: 44.3434
Created: 22-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
4ZR0_A   229 FCVGVFVWTLIEYGLHRfLFHFdd----wLPesniAfaTHFlLHGC-HH-YLPMDK-YRLVMPPTLFVILCA--PFYKLV 299 Saccharomyces cerev...
Q06AR9   150 SVGAAVGMEFWARWAHRaLWH--------AS-------LWH-MHES-HHkPREGPF-ELNDVFAIINAVPAI--ALLNFG 209 Adonis aestivalis v...
Q6X3I7    47 AALGLVAWSLLEYLLHRfVLHG-------LS-------PFRqWHQS-HH--QRPGA-LIGLSTLSSAALFIG--LVYLPA 106 Pseudomonas aeruginosa
Q1DFV0    44 MLAASVAFPFGWYLVHKhILHSr-----fLYksplTaaTWKrIHFD-HH--QDPHD-LRVLFGALANVLPTVggVIAPIG 114 Myxococcus xanthus ...
Q5NMN7    19 IAVAILGFPLVWYVTHRwIMHGh-----wMFkvpfLsgLWKrIHYD-HHlDPDHLEvLFGALYTTLPSVALAtaLPGY-- 90  Zymomonas mobilis
Q0RCQ7    69 AMAAALAQPFVEWGVHRlLLHArp----aSRlgavGyqLAGyGHEQ-HHrDPAD---LDTMFLRPREVITGT--AAAALP 138 Frankia alni ACN14a
Q5Z3I7    53 PLVMVAVFPVFEWVVHVlVLHWrpkrlgrLT----LdsELArKHRE-HHiDPREIP-LIFIPTRSLVIVLVA--LLLIAA 124 Nocardia farcinica
EDM81439  63 VAAILAVHPFAEWIIHVfILHHrprtvtvLGkplrWdyDAArKHRL-HHrDPWDIR-HVLIPLPILAFGLSL--NGSVAL 138
ABL97308  43 FFIPIILAPFYEWYVHKyQLHRe------LTkkegW---YRrYQIIlHHgHHRDPD-NIKLQFAPWRYLIYTy-GQVYLL 111
Q6B3A6    39 MLAGLLVWSLLEYSLHRfLFHS----------------LYRrEHWT-HH--VDVLA-YIGVSSWKISSVYSG--LLLFAS 96  uncultured proteoba...

4ZR0_A   300 FALLP--LYWAYAGfaGGLFGYVCYDECHFFlHhSKLPPFm-------RKLKKYHLEHHY-KNYQLGFGVt-SWF-WDEV 367 Saccharomyces cerev...
Q06AR9   210 FFHKGliPGLCFGAglGITVFGMAYMFVHDGlVhRRFPVGpianvpyfRKVAAAHQIHHTdKFQGVPYGLflGPKeLEEV 289 Adonis aestivalis v...
Q6X3I7   107 LLALG--PWRGSSLalGIMSGYLAYILTHHAvHhFDHSGNaw-----lARRQLCHHLHHSaLWQAGHFGVt-SAF-WDRL 177 Pseudomonas aeruginosa
Q1DFV0   115 YLIGG--KAGAAAAlgWAMVITCFYEFCHCI-QhLNYTPKsq----flKDIKRLHLSHHF-HNEQGNYGIt-NYF-WDRL 184 Myxococcus xanthus ...
Q5NMN7    91 -LIGG--FGGACIGyaVGLLSTCFYEFCHCI-QhLGYKPKnk----rlALMKKRHLEHHF-HDEDGNFGIt-NFF-WDKL 159 Zymomonas mobilis
Q0RCQ7   139 A-LFG--PPSAATGalCAGVGVLAYDWTHFL-IhTRVPPRta----yyRRLWRGHRLHHY-RNERYWLGVt-SPL-GDLA 207 Frankia alni ACN14a
Q5Z3I7   125 FAFPR--PGLGLTFllTVTVLGLGYEWTHYL-IhTDYKPRra----lyRAVWRNHRHHHY-KNEHYWFTVtsSGT-ADRL 195 Nocardia farcinica
EDM81439 139 AVLPT--PGLAGTFaaTIAAIVLYYEWIHFL-VhTSYRPRga----lyRRQWRLHRLHHF-KNERYWLGVt-RHF-GDRA 208
ABL97308 112 YSLILwsFPAAMVPftGHLVYHLWYEWIHLAhHsKEYKPVsi----igKKLRDAHMSHHF-HNENYNWGI--TNMiGDYF 184
Q6B3A6    97 FAGLT--SAFAGLVlgYFTYISLHYV-MHRP-----RHWAyr----fiPRLVANHDLHHR-KGVEKNFGVs-SPL-WDHL 161 uncultured proteoba...

4ZR0_A   368 FGT 370 Saccharomyces cerevisiae S288C
Q06AR9   290 GGN 292 Adonis aestivalis var. palaestina
Q6X3I7   178 FAS 180 Pseudomonas aeruginosa
Q1DFV0   185 FGT 187 Myxococcus xanthus DK 1622
Q5NMN7   160 LGT 162 Zymomonas mobilis
Q0RCQ7   208 LRT 210 Frankia alni ACN14a
Q5Z3I7   196 FGT 198 Nocardia farcinica
EDM81439 209 LGT 211
ABL97308 185 FGT 187
Q6B3A6   162 FRT 164 uncultured proteobacterium QS1
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