Conserved Protein Domain Family
purH

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PRK00881: purH 
bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional
Statistics
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PSSM-Id: 234854
Aligned: 761 rows
Threshold Bit Score: 677.579
Created: 9-Dec-2010
Updated: 25-Oct-2021
Structure
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Aligned Rows:
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
86610272   12 QDSVPLALLSVSDKTGLIPLAQSLVQeHGFQLLSSGGTAKALSEAGIPVTPVSAHTGAPEILGGRVKTLHPRIHGGILAR 91 
58038903    5 RLPVRRALLSVSDKTGLIELGRALAA-HGAELLSTGGSAKALREAGLTVKDVSEHTGFPEILDGRVKTLVPQVHGGILGR 83 
148259048   4 RVNIRRALISVSDKAGLVELGRALAA-AGVEILSTGGSARALREAGIAVVEVADYTGVPEMLDGRVKTLVPKIHGGLLGR 82 
56550923    3 DIAIKTALLSVSDKTGLVELGQALAA-HDIKLISTGGTAKLLRDAGLAVTDISDFTGFPEMMDGRVKTLHPKVHGGLLAV 81 
260753383   3 DIAIKTALLSVSDKTGLVELGQALAA-HDIKLISTGGTAKLLRDAGLAVTDISDFTGFPEMMDGRVKTLHPKVHGGLLAV 81 
148553371  11 KVAIKRALLSVSDKSGLVELGRALAG-WGVELVSTGGTAKALRDAGLDVKDISDITGFPEMMDGRVKTLHPMVHGGLLSV 89 
294010286   3 DVTIKRALLSVSDKSGLIELGQALGR-HGVELVSTGGTAKALREAGLAVKDISDLTGFPEMMDGRVKTLHPKVHGGLLAV 81 
85375335    3 DVVIKRALLSVSDKTGLVELGQALAD-HGVELVSTGGTAKALREAGLQVKDISDLTGFPEMMDGRVKTLHPKVHGGLLAV 81 
87198132    3 EVTIKRALLSVSDKSGLVDLGKALAA-RGVELLSTGGTAKALRDAGLAVKDVSEHTGFPEMMDGRVKTLHPTIHGGLLAV 81 
114328311  19 TAPIRRALISVSDKTGLIPFAKALAV-GGVEILSTGGSAAALREVGVAVKDVSAHTGFPEILDGRVKTLVPQIHGGILGR 97 
86610272   92 LECSEDRADLEALGIPPIQLVVVNFYPFEQTVAQaGVSLEEAFEQIDIGGPTLARAAAKNYPYVTVLTDPSQYPRYLQLL 171
58038903   84 RDLPAHVAQMAEHGIAPIDLVCVNLYPFAATVAS-GAGDEDCIENIDIGGPAMIRAAAKNFDHVTILTDPRQYAAVIASL 162
148259048  83 RDLPEHLAQMQRHDIPPIDLLAVNLYPFEETVAK-GSDFETCVENIDIGGPALIRAAAKNHDSVAVLTSPAQYDDLIAAL 161
56550923   82 RNNPEHVAAMKAHDISAIDLVVVNLYPFRETVAK-GAGRQEVIENIDIGGPSMVRSAAKNHDHVTIVTDPKDYPSLISEL 160
260753383  82 RNNPEHVAAMKAHDISAIDLVVVNLYPFRETVAK-GAGRQEVIENIDIGGPSMVRSAAKNHDHVTIVTDPKDYPSLISEL 160
148553371  90 RDDPEHAKAMTDHGIGAIDLVVVNLYPFAQTVAK-GAGRDEIIENIDIGGPSMVRSAAKNHAYVTIATDPADYAEIIASg 168
294010286  82 RGNAEHVAAMQAHDIGAIDLVVVNLYPFAATVAK-GADREEIIENIDIGGPSMVRSAAKNHESVAIVTDPADYARLVAEM 160
85375335   82 RDNAEHAAAMEEHDIGAIDLVVVNLYPFEATVMR-GAERDEIIENIDIGGPSMVRSSAKNHAYVTIVTDPADYETLLGEM 160
87198132   82 RDNPEHAAAMAEHAIGAIDLVVVNLYPFEATVAK-GAEREEVIENIDIGGPSMVRSAAKNHEYVTILTDAADYAAFLGEL 160
114328311  98 RDLPEHVAQMNEHDIAPIDLVCVNLYPFEATVAS-GADFETCVENIDIGGPALTRAAAKNHDHVTIVTDPAQYDAVLEQF 176
86610272  172 SGAyGETErLAFRFQCARRAFEQVLAYDRAIVTYLarlelagpsqssAAA------AEDRFQLQGILWQRLRYGENPHQA 245
58038903  163 EQG--GTV-LAERRDYAASAYAHTAAYDSMISRWF------------AKQag--etLPPVLTLSGTRDDLLRYGENPHQK 225
148259048 162 AAG--GTT-LEQRRRLAAAAYARTAAYDAAISAWF------------AQQtg--emFPAHLALAGARQQMLRYGENPHQS 224
56550923  161 ADNgGATT-LDSRRRFAAKAYAATAQYDAAISAWF------------A-Adlk-edLPELLTVPLKKASALRYGENPHQK 225
260753383 161 ADNgGATT-LDSRRRFAAKAYAATAQYDAAISAWF------------AADlk--edLPELLTVPLKKASALRYGENPHQK 225
148553371 169 ----GTTD-FALRKRFAAKAFAATATYDAMISSWF------------AHAdqg-qfFPEALSIPVRKAEELRYGENPHQQ 230
294010286 161 EEKgGATS-YDFRRMLAAKAYAATAAYDSMIASWF------------AFAdqg-aqFPESLSVSSRLGSTLRYGENPHQS 226
85375335  161 KDG-GATS-LDFRKAMAAKAFAATASYDSMISQWFafa-------dqGQL------FPDMLAINGKAPTPLRYGENPHQM 225
87198132  161 DQTgGATT-LAFRRKMAAKAYAATAAYDAAISQWF------------ATVdqq-ehFPPVLAAAHTRVTTLRYGENPHQD 226
114328311 177 TAH-GGTD-ATLRRRLAAAAFSRTAAYDSAIATWF------------ATQgtvqeeFPRHFSIGGSLRQGLRYGENPHQS 242
86610272  246 ATWYVTDPAa-------PGWHRAKQLQGKELSYNNLLDLEAARALAAELtlllrnADatrptdgkgsVssgsarreflqp 318
58038903  226 AAFYRDGSQr-------PGVASARQVQGKALSYNNINDTDAAFEAVAEF------DE----------P------------ 270
148259048 225 AAFYRTGNR--------PGVATARQLQGKELSYNNINDTDAAFECVAEFd----------------rP------------ 268
56550923  226 AALYIPTLPnlpewpivNGIAQAEQIQGKALSYNNYGDADAALDLISEFc----dAa----------P------------ 279
260753383 226 AALYIPTLPnlpewpivNGIAQAEQIQGKALSYNNYGDADAALDLISEFrd--------------aaP------------ 279
148553371 231 AALYLPVGPs------aRGIAQATQVQGKELSYNNYNDADAALELVSEFr----dGp----------P------------ 278
294010286 227 AALYLPVGPs------aNGIAQARQVQGKELSYNNYNDADAALELVSEFr----dGp----------P------------ 274
85375335  226 AALYTPVGPh------tQGIAQAKQVQGKELSYNNYNDADAALELCAEFke--------------gdP------------ 273
87198132  227 AALYVPRNPa------vTGLPQATQVQGKELSYNNYNDANAALELVAEFag--------------akP------------ 274
114328311 243 AAFYALGAR--------PGVATARQLQGKELSYNNINDTDAAFECVAEF------EQ----------P------------ 286
86610272  319 eqaVAVVVKHNNPCGVAIRPSPAAALEAALAADPVSAFGGIVALNQPLDAETARRLVEPFLECVVAPDCTPEAAELLSVK 398
58038903  271 ---TVVIVKHANPCGVASATTLEQAWIAALRCDPVSAFGGIVAVNRTLNGATAQRISKIFTEVIVAPDADAEAIEVLSRK 347
148259048 269 ---AVVIVKHANPCGVALGADLAEAWDRALDCDPVSAFGGIIAVNRPLDVAAAEKMASIFSEVIIAPDAAPDAVELLARK 345
56550923  280 ---TVVILKHANPCGVASGDSLIEAYKAALACDSVSAFGGIIAVNRPLDGATAEAITSIFTEVVVAPAADEAAKAIFAKK 356
260753383 280 ---TVVILKHANPCGVASGDSLIEAYKAALACDSVSAFGGIIAVNRPLDGATAEAITSIFTEVVVAPAADEAAKAIFAKK 356
148553371 279 ---TVVIVKHANPCGVASADTLIEAYEAALACDSVSAFGGIIAVNRPLDGKTAEAISGIFTEVVAAPDADDDAKAVFAKK 355
294010286 275 ---TVVIVKHANPCGVATGATLIEAYEAALACDSVSAFGGIIAVNRPLDGPTAEAISGIFTEVVAAPDADEDAKAIFAKK 351
85375335  274 ---AVVIVKHANPCGVAQAGSLLEAWEQALACDSVSAFGGIVAVNRTLDGPTAEAIAKIFTEVVVAPDADEAAREAFAKK 350
87198132  275 ---TVVIVKHANPCGVATAETLLEAWKDALECDSVSAFGGIVATNVPLDGPTANAICEIFTEVVVAPGADDAAKEAFARK 351
114328311 287 ---SVVIVKHANPCGVASAASLAEAWDLALRCDPVSAFGGIVALNRTLDAEAAERITSIFSEVIVAPDADKAALEIVARK 363
86610272  399 KNLRVLILpd----lcVGP------AQ-TIRTLAGGFLVQDADSPvALQrcrdqeptqtdsPPSWQVVTQRQPTPEEWAD 467
58038903  348 KNLRLLLT--------DGVpdptaeGL-AFRSVAGGFLAQTRDAG-RVT------------EADLKVVTKRAPTAQEMKD 405
148259048 346 KNLRLLLT--------GGLpdpaepGL-AWRSVAGGFLAQTRDAG-RIG------------RDDLKVVTQRAPTNAEFAD 403
56550923  357 KNLRLLIT--------GALpdp-krNGlNLRSIAGGILLQSRDGS-LLD------------EQALQVVTEVKPSEQQMKD 414
260753383 357 KNLRLLIT--------GALpdp-krNGlNLRSIAGGILLQSRDGS-LLD------------EQALQVVTEVKPSEQQMKD 414
148553371 356 KNLRLLLT--------GELpdp-arAGmTMKSIAGGVLLQSRDNG-RIG------------LDDLKVVTKRAPTDQELKD 413
294010286 352 KNLRLLLT--------GDLpdp-arPGlQIKSIAGGLLVQGRDNG-RIT------------RDQLKVVTKRAPTEQELND 409
85375335  351 KNLRLLLTgdlpdprrGGL---------AVKPITGGLLVQSRDNG-ALT------------VDALKVVTEREPSEQELKD 408
87198132  352 KNLRLLLI--------DSLpdagrkGL-VTVPIAGGLLVQDRDAG-KID------------KSDLKVVTKRAPTERELED 409
114328311 364 KALRLLLT--------GGMpdpaeqGM-AVRSVAGGLLVQTRDNG-RIQ------------RQDLRVVTKRVPTDAEWRD 421
86610272  468 LEFAWIVCKHVKSNAIVVAKQRQTLGVGAGQMNRVGAAEIALQQAGSQA----------AGAVLASDGFFPFADSVEMAA 537
58038903  406 LLFAFRVAKHVKSNAVIYVRNEATVGIGAGQMSRVDSARIAARKSEDAAkeagerapltTGSVAASDAFFPFADGLESVV 485
148259048 404 LLFAFRVAKHVKSNAIIYAKAGATTGIGAGQMSRVDSSRIAAQKGGek----------iPGSVVASDAFFPFADGLVAAI 473
56550923  415 ALFAWTVAKHVKSNAIVYARDNATVGIGAGQMNRLESARIAAWKAEDAAkragwpesrtRGSAVASDAFFPFADGLVTAT 494
260753383 415 ALFAWTVAKHVKSNAIVYARDNATVGIGAGQMNRLESARIAAWKAEDAAkragwpesrtRGSAVASDAFFPFADGLVTAT 494
148553371 414 CLFAWTVAKHVKSNAIVYARGGSTAGVGAGQMNRLESARIAAWKAKDAAekagwatprtIGSAVASDAFFPFADGLLAAV 493
294010286 410 CLFAWTVAKHVKSNAIVYAKAGSTAGIGAGQMNRLESARIAAWKAKDAAekagwaeartLGSAVASDAFFPFADGLLAAV 489
85375335  409 CLFAWTVARHVKSNAIVYAKDGATAGIGAGQMNRRDSSRIAAMKAAEAAekydwpqprtVGSAVASDAFFPFADGLLAAA 488
87198132  410 ALFAWTVAKHVKSNAIVYAKDGVTAGIGAGQMNRRDSSRIAAAKAREAAethhfsevrtVGSAVASDAFFPFADGLMAAV 489
114328311 422 LLFAFRVCKHVKSNAIIYAKDLATTGIGAGQMSRVDSARIAAQKGGal----------iAGSVVASDAFFPFADGLEAAS 491
86610272  538 QAGIRAIIQPGGSIRDADSIAAANAAGIAMVCTGIRHFLH 577
58038903  486 AAGAVAVIQPGGSIRDQEVIDAADAAGIAMVFTGMRHFRH 525
148259048 474 EAGATAVIQPGGSIRDNEVIEAADAAGIAMVFTGMRHFRH 513
56550923  495 EAGATTVIQPGGSIRDQEVIDAANKAGIAMIFTGTRHFRH 534
260753383 495 EAGATTVIQPGGSIRDQEVIDAANKAGIAMIFTGTRHFRH 534
148553371 494 EAGATAVIQPGGSIRDAEVIAAADEAGLAMVFTGMRHFRH 533
294010286 490 EAGATAVIQPGGSIRDEEVIAAADEAGLAMVFTGMRHFRH 529
85375335  489 EAGATAVIQPGGSIRDDEVIEAANKAGLAMVFTGMRHFRH 528
87198132  490 EAGATCVIQPGGSIRDEDVIKAADEAGLAMVFTGMRHFRH 529
114328311 492 AAGATAVIQPGGSVRDDEVIAAADAAGLAMVFTGMRHFRH 531
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