Conserved Protein Domain Family
7tmA_OR52A-like

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cd15955: 7tmA_OR52A-like 
olfactory receptor subfamily 52A and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors
This group includes human olfactory receptor subfamily 52A and related proteins in other mammals and sauropsids. Olfactory receptors (ORs) play a central role in olfaction, the sense of smell. ORs belong to the class A rhodopsin-like family of G protein-coupled receptors and constitute the largest multigene family in mammals of approximately 1,000 genes. More than 60% of human ORs are non-functional pseudogenes compared to only about 20% in mouse. Each OR can recognize structurally similar odorants, and a single odorant can be detected by several ORs. Binding of an odorant to the olfactory receptor induces a conformational change that leads to the activation of the olfactory-specific G protein (Golf). The G protein (Golf and/or Gs) in turn stimulates adenylate cyclase to make cAMP. The cAMP opens cyclic nucleotide-gated ion channels, which allow the influx of calcium and sodium ions, resulting in depolarization of the olfactory receptor neuron and triggering an action potential which transmits this information to the brain. A consensus nomenclature system based on evolutionary divergence is used here to classify the olfactory receptor family. The nomenclature begins with the root name OR, followed by an integer representing a family, a letter denoting a subfamily, and an integer representing the individual gene within the subfamily.
Statistics
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PSSM-Id: 320621
Aligned: 6 rows
Threshold Bit Score: 397.987
Created: 17-Dec-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
  next features
Feature 1:putative ligand binding pocket [chemical binding site]
Evidence:

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
Feature 1                                                                #  ##           ###### #
Q9H2C5        27 CWIGIPFSAMYLIGVIGNSLILVIIKYENSLHiPMYIFLAMLAATDIALNTCILPKMLGIFWfhlPEISfdaCLFQMWLI 106 human
XP_006885749  27 HWIGIPFFISFILAVFGNGLLITVIRTERSLHePMYIFLSVLAATDLGLTLCITPKMLAIFWlqsREIHfdsCLIQMYFT 106 Cape elephant s...
NP_001000745  28 FWIGFPFFTVCLVAVLGNVVLLIIIPAERSLHqPMYIFLAVLAATDIGLCAAIAPKMLAIFWfqaYSMVfdaCLAQLFFI 107 Norway rat
XP_001507086  27 HWIGIPFCGMFTVAVLGNCTVLIVIKRNPELHqPMYLLLAMLALNDLGICPTIVPKTLGIFWfnlREIQfnsCLAQMFFV 106 platypus
XP_001375786  30 HWIGIPFCIMILLALMGNCTILSVIWRDPSLHqPMYLLLAMLAINDLGIFPVLFPKTLAILWfdiKEIEfnvCLTQMFFV 109 gray short-tail...
XP_006036767  28 VWIAIPFCVMYILAVTGNCTLLAIIKTERSLHePMYIFLAMLAGTDLVLSTCILPKMLGIFWfgsRDISfnaCLVQMFFI 107 Chinese alligator
Feature 1        #  #                                            # #####                         
Q9H2C5       107 HSFQaIESGILLAMALDRYVAICIPLrHATIFsQQFLTHIGLGVTLRAAILIIPSLGlik-ccLKHYRTtVISHSYCEHM 185 human
XP_006885749 107 HTFQcMESGILLAMAFDRYVAICEPLrHSAILtKKVLISIIMVVTIRASVIIIMCPLlik-lrLKHFRTtIISHSYCEHM 185 Cape elephant s...
NP_001000745 108 HTLQcMESGILLAMAFDRYIAICDPLrHTSILtPSILGRMIVVVVVRAVVLVGLLPLli--krLHHFQSiHIAHSYCEHM 185 Norway rat
XP_001507086 107 HVLAaFETGILVAMALDRYVAICHPLrYSSILtPNVLLGMGLLVVLRGVFMILPFLLlikarvNSFRST-VVPHTYCEHM 185 platypus
XP_001375786 110 HVLAgFETGILVAMALDRYVAICRPLrYTAILtPHVLLGIAVMVVVRAVLLISFCPIlik-lrLTSFHStVVAHSYCEHM 188 gray short-tail...
XP_006036767 108 HTFQaVESGVLLAMAFDRYVAICNPLrHSSIFtTQVLFRIGILLVMRPTALIIPSICli--krLHFYKStAISHAYCEHM 185 Chinese alligator
Feature 1                    #  ### ### ##                                            #  ## ##  #
Q9H2C5       186 AIVKLATEDirvNKIYGLFVAFAILGFDIIFITLSYVQIFITVfqlpqkEARFKAFNTCIAHICVFLQFYLLAFFSFFTH 265 human
XP_006885749 186 AVVKLAAENvkvNKAYGLFVAFSVLGFDVIFIFLSYAFIFRAVfklpqkEARFKAFNTCTAHIFVFLQFYILTFFTSFIH 265 Cape elephant s...
NP_001000745 186 AVVKLAADDvriNKICGLFVGFSILGFDMVFILISYALIFQAVfrlqqkEARLKAFNTCTAHIFVFLEFYILAFFSFFSH 265 Norway rat
XP_001507086 186 AVLKLATDDtrvNRIYGLAVVFIIFWFDSSFITTSYTLIFKAVfrlpgkEARLKAFNTCTAHIIIIMLTYTLALFSFLGH 265 platypus
XP_001375786 189 AVVKLAAGDtrvNKFYGLAVVMTFCWCDICFISTSYILIFRAVmrlpgkEARVKAANTCTAHITIIVLSYSLALFSFLAH 268 gray short-tail...
XP_006036767 186 AVVKLAAVDvrvNKAYGLFVAFTILGVDIIFITVSYILILRAVfrlpqkEAHLKAFHTCTAHICVFLEFYTLGFFSFFAH 265 Chinese alligator
Feature 1               ## ###  #  ##                 
Q9H2C5       266 RFGshiPPYIHILLSNLYLLVPPFLNPIVYGVKTKQI 302 human
XP_006885749 266 RFGfnvAPYVHILLSNLYLLVPPLLNPIVYGVKTKQI 302 Cape elephant shrew
NP_001000745 266 RLGh-vVPSTHILLSTIYLLLPPALNPIVYGVKNMVI 301 Norway rat
XP_001507086 266 RYGhhlTPYVHILLANFYLLVPTVVNPIIYGAKTKEI 302 platypus
XP_001375786 269 RYGhrvAPYVHILLANIYLLVPPVVNPIVYGVKTKEI 305 gray short-tailed opossum
XP_006036767 266 RFGhhvAPYIHILLSSLYLLVPPLLTPIVYGVNTKQI 302 Chinese alligator

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