Conserved Protein Domain Family
PAC4

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pfam16093: PAC4 
Proteasome assembly chaperone 4
PAC4 or proteasome assembly chaperone 4 protein promotes assembly of the 20S proteasome. It interacts with PSMG3. It associates with alpha subunits of the 20S proteasome. At the very C-terminal is a crucial HbYX or hydrophobic-tyrosine-X sequence motif that, in proteasome activators, opens the 20S proteasome entry pore.
Statistics
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PSSM-Id: 465017
Aligned: 109 rows
Threshold Bit Score: 32.1539
Created: 26-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
EEC44288             50 ITFSkkAATIwFGWGSLQSSKTsgpggnagygatpvgakslcvgtapnlsmGPLVVAMPRPRYkgsLSISaepsTSKLIG 129
WGS:AATM:SJAG_04197  33 VVFLypSDAV-FIWASNKASAPf----------------------------GSMSLAMPSLNParrGEIV----SSTLTG 79 
Q9P7J0               23 VIKLnpSSSI-FVWGSNVSTCPa----------------------------GDLALSMPGk-----SDVV----TTKLTG 64  Schizosa...
WP_013255933         15 FTLFqiGEDLlLVIAGGQTPHI-----------------------------GAVTLSLPRKSL---TDDGstssSTSVLA 62  Sedimini...
jgi:Nmar_1598        23 IQKF--DNGY-FISVAEGSNKI-----------------------------GSMVASIATGPTp---------iTTTIIP 61 
XP_002017705         51 ALKM--NGST-MLIVNSKENEVf----------------------------DELAVGMPARDSt-kSDAL----SSTLMG 94 
EDW47645             35 ALKM--QGST-MLIINPKGSEVf----------------------------EELAVAMPSRNPa-sSQSV----SSTILG 78 
WGS:AANI:GJ21227-PB  51 VLKM--NGST-MLFLSGKDAERl----------------------------DEFAIAMPARPPs--QQIV----STTFMG 93 
EDW01723             44 VLKM--NGST-MIFLSGKESERl----------------------------DEFAVAMPARPPc--KQIV----ATTFMG 86 
XP_002004510         54 VLKM--NGST-LIFLGTTDAERv----------------------------DEFAMAMPSRPPs--KQIV----STTFLG 96 
EEC44288            130 YDDEGDemVARQMSSRLSQRLGIAIFVSCSF 160
WGS:AATM:SJAG_04197  80 IGSVDE--SSNRLSRILSARFRRQVFATTEL 108
Q9P7J0               65 AGSIDD--LSTQMSRILSKKFQAQVYTSINL 93  Schizosaccharomyces pombe 972h-
WP_013255933         63 VPAHKDdeIARSVSAHISSRLNRNVVVACGI 93  Sediminispirochaeta smaragdinae
jgi:Nmar_1598        62 SR--TEslFLKLVSERISTRM-RGIALVSAF 89 
XP_002017705         95 GY-GQT--ESSVLAAKLSKRYGRQFFVSLNI 122
EDW47645             79 GH-GQT--DSSVLAAKLSKRYCRQFYVSLNL 106
WGS:AANI:GJ21227-PB  94 ES-GQS--DSVVLATKLSMRHRRQFYVSMNL 121
EDW01723             87 SS-GHS--DSLVLATKLSTRYGRQFYVSFNL 114
XP_002004510         97 ES-GQS--DSLVLANKLAMRYGRQFYVSFNL 124
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