2DGS,1CVJ,1CVJ,1FJE,1FJE,1FXL,1FXL,1H2T,1HD0,1JMT,1O0P,1OWX,1UFW,1UP1,1UW4,1WEY,1WF2,1WG4,1WHW,1WHX,1WHY,1WI8,1WTB,1WWH,1X4A,1X4E,1X4F,1X4G,1X4H,1X5O,1X5S,1X5T,1X5U,1YTY,2AD9,2ADB,2ADC,2ADC,2BZ2,2CJK,2CPF,2CPH,2CPI,2CPZ,2CQ0,2CQ2,2CQ4,2CQD,2CQG,2CQH,2CQI,2D9O,2D9P,2DGQ,2DGX,2DH9,2DHG,2DHX,2DIS,2DIT,2DIU,2DIV,2DK2,2DNG,2DNL,2DNQ,2DO0,2DO4,2E44,2E5G,2E5H,2E5J,2ERR,2FC8,2FC9,2G4B,2G4B,2GHP,2GO9,2HGM,2I2Y,2J8A,2JRS,2K3K,2KH9,2KI2,2KM8,2KRB,2KT5,2L9W,2LA6,2LEA,2LXI,2MKI,2MKS,2MSS,2MTG,2MZJ,2MZR,2MZS,2MZT,2N6D,2N6D,2OSQ,2QFJ,2QFJ,2RRA,2RT3,2U1A,2WBR,2XNR,2XS5,2YTC,2YWK,3B4D,3BS9,3D2W,3D45,3DXB,3EGN,3EX7,3H2V,3LPY,3LQV,3MD1,3MOJ,3N9U,3PGW,3S6E,3S8S,3SDE,3SDE,3SMZ,3SMZ,3TO8,3TYT,3U1L,4A8X,4C7Q,4E8U,4ERD,4P6Q,4P6Q,4P6Q,4WKR,5DET,5LJ3,5O1W,5OSG,5OSG,5T9P,5UZ5,5X8R,5X8R,5ZOJ,6ES4,6EXX,6EZ7,6FF4,6G6S,6G90,6GD2,1U6F


Conserved Protein Domain Family
RRM_SF
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cd00590: RRM_SF 
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RNA recognition motif (RRM) superfamily
RRM, also known as RBD (RNA binding domain) or RNP (ribonucleoprotein domain), is a highly abundant domain in eukaryotes found in proteins involved in post-transcriptional gene expression processes including mRNA and rRNA processing, RNA export, and RNA stability. This domain is 90 amino acids in length and consists of a four-stranded beta-sheet packed against two alpha-helices. RRM usually interacts with ssRNA, but is also known to interact with ssDNA as well as proteins. RRM binds a variable number of nucleotides, ranging from two to eight. The active site includes three aromatic side-chains located within the conserved RNP1 and RNP2 motifs of the domain. The RRM domain is found in a variety heterogeneous nuclear ribonucleoproteins (hnRNPs), proteins implicated in regulation of alternative splicing, and protein components of small nuclear ribonucleoproteins (snRNPs).
Links
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Statistics
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PSSM-Id: 409669
Aligned: 451 rows
Threshold Bit Score: 27.6324
Created: 6-Mar-2002
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
2DGS_A        13 IFVGGIphn------cgETELREYFkkfgvvtEVVMIydaek------------qrprGFGFITFEde--------qSVD 66  human
2J8A_A         5 IVVYPAqdstt--tniqDISIKNYFkkygeisHFEAFndpns------------alplHVYLIKYAssdgkindaakAAF 70  baker's yeast
2KRB_A         4 IVVDNVpqvgpdrleklKNVIHKIFskfgkitNDFYPeedg--------------ktkGYIFLEYAsp--------aHAV 61  human
2QFJ_A        31 VYVGSIyye------lgEDTIRQAFapfgpikSIDMSwdsvt------------mkhkGFAFVEYEvp--------eAAQ 84  human
2QFJ_A       128 IYVASVhqd------lsDDDIKSVFeafgkikSATLArdptt------------gkhkGYGFIEYEka--------qSSQ 181 human
17380398     260 VVVGLIgpn------itKDDLKTFFekvapveAVTISsnr----------------lmPRAFVRLAsv--------dDIP 309 fruit fly
19173032     173 IYVSNIpye------cdKRDLKKYFegmgevvGMSLPydrdn------------nrlkGYGFVDFGnk--------eDYE 226 Encephalitozoon...
Q9W123       217 LYVGNIpfn------mtTSAIKAYFana-mrvDIGVLkre---------------kraRYAFVRYAsp--------dQTM 266 fruit fly
XP_004340643 253 IYVGSLnfe------lsEEDIKTAFspfgpvkSVSLTkdplt------------qrskGFAFVEYAyp--------dAAT 306 Acanthamoeba ca...
Q9P6M8        19 IYVGNIdsr------lsDEEIIKHFskygqveSIFRRlldsfypkekakpfkppkngvQYGFVKFVna--------eSIE 84  fission yeast

2DGS_A        67 QAVNmhfhd---imgkKVEVK 84  human
2J8A_A        71 SAVRkhessgcfimgfKFEVI 91  baker's yeast
2KRB_A        62 DAVKnadgyk-ldkqhTFRVN 81  human
2QFJ_A        85 LALEqmnsv--mlggrNIKVG 103 human
2QFJ_A       182 DAVSsmnlf--dlggqYLRVG 200 human
17380398     310 KALKlhste---lfsrFITVR 327 fruit fly
19173032     227 RVLKkklv----fedsTMYHR 243 Encephalitozoon cuniculi
Q9W123       267 EAFKelvds--plnsrTLTVR 285 fruit fly
XP_004340643 307 AALKhmngf--mlagrQLKVG 325 Acanthamoeba castellanii str. Neff
Q9P6M8        85 EVLKdakgm--tlgqrKLTIK 103 fission yeast
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