Conserved Protein Domain Family
Pmev_kin_ERG8
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TIGR01219: Pmev_kin_ERG8 
phosphomevalonate kinase, ERG8-type, eukaryotic branch.
This enzyme is part of the mevalonate pathway, one of two alternative pathways for the biosynthesis of IPP. In an example of nonorthologous gene displacement, two different types of phosphomevalonate kinase are found - the animal type and this ERG8 type. This model represents plant and fungal forms of the ERG8 type of phosphomevalonate kinase. [Central intermediary metabolism, Other]
Links
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Statistics
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PSSM-Id: 273509
Aligned: 3 rows
Threshold Bit Score: 697.852
Created: 8-Oct-2014
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
AAG31307   4 VASAPGKVLMTGGYLVLEKPNAGLVLSTNARFYAIVKPINEEVKpeswAWKWtDVKLTSPQLS-RESMYKLSLNhltl-- 80  thale cress
P24521     6 AFSAPGKALLAGGYLVLDTKYEAFVVGLSARMHAVAHPYGSLQG----SDKF-EVRVKSKQFKdGEWLYHISPKs----- 75  Saccharomyces cerev...
CAB52264   4 TCSAPGKVLIAGGYIVLDPQYSGLVIGLTAKGYASTTTLDDKCG---------TVRVKSPQFInAEWLYNIDWTvspirv 74  fission yeast

AAG31307  81 qsvSASDSRNPFVEHAIQYAIAAAHLatEKDKESLHKLLLQGLDITILGSNDFYSYrnqiesaglpltPESLGTLAPFAS 160 thale cress
P24521    76 --gFIPVSIGGSKNPFIEKVIANVFS--YFKPNMDDYCNRNLFVIDIFSDDAYHSQ------------EDSVTEHRGNRR 139 Saccharomyces cerev...
CAB52264  75 hqiYENCELEKNPNPFVQLALFYVIN--YFFSTGRQPLCWQDLQVTLQVDNAYYHQ------------PQLKPDQTSYPK 140 fission yeast

AAG31307 161 ITFNAAEsngansKPEVAKTGLGSSAAMTTAVVAALLHYLGVVDLSDPCKegkfgcsDLDVIHMIAQTSHCLAQGKVGSG 240 thale cress
P24521   140 LSFHSHR------IEEVPKTGLGSSAGLVTVLTTALASFFVSDLENNVDK-------YREVIHNLAQVAHCQAQGKIGSG 206 Saccharomyces cerev...
CAB52264 141 FNFLNCT------LGQVHKTGLGSSAAMITSLIGSLFLSLRRLTDDTGDKslkiddsTKVIVHNLAQIAHCSAQGKVGSG 214 fission yeast

AAG31307 241 FDVSCAVYGSQRYVRFSPEVLSFAQv----AVTGLPLNEVIGTILKGKWDN-KRTEFSLPPLMNLFLGEPGsGGSSTPSM 315 thale cress
P24521   207 FDVAAAAYGSIRYRRFPPALISNLP-----DIGSATYGSKLAHLVDEEDWNiTIKSNHLPSGLTLWMGDIK-NGSETVKL 280 Saccharomyces cerev...
CAB52264 215 FDVGAATWGSCIYRRFDPKLIEQLLvpydeQIKNINFSTELRKIVSKKWS--DVVPFQLPATYCLLMGDVA-GGSSTPGM 291 fission yeast

AAG31307 316 VGAVKKWQMSDPEKARENWQNLSDANLELETKLNDLSKLAKDHWDVYLRVIKscsVLTSEKWVLHATEpineaiikELLE 395 thale cress
P24521   281 VQKVKNWYDSHMPESLKIYTELDHANSRFMDGLSKLDRLHETHDDYSDQIFE---SLERNDCTCQKYP--------EITE 349 Saccharomyces cerev...
CAB52264 292 VKKVQQWQKENPEESKNCFDDLYSR------------------------------VLSIKNCFLSSES--------LDSE 333 fission yeast

AAG31307 396 AREAMLRIRILMRQMGEAASVPIEPESQTQLLDSTMSAEGVLLAGVPGAGGFDAIFAITLG--DSGTKLTQAWSSHNVLA 473 thale cress
P24521   350 VRDAVATIRRSFRKITKESGADIEPPVQTSLLDDCQTLKGVLTCLIPGAGGYDAIAVITKQdvDLRAQTANDKRFSKVQW 429 Saccharomyces cerev...
CAB52264 334 LQSQFRSIRRILQRITVEAKVDIEPLKQTNILDNIEQLPGVIGVGVPGAGGFDAQFCLAINhtEIIENVIKTWKDDGVVP 413 fission yeast

AAG31307 474 LLVREDPHGVCLESgDPRT 492 thale cress
P24521   430 LDVTQADWGVRKEK-DPET 447 Saccharomyces cerevisiae S288c
CAB52264 414 MDVSPAFDGLAVE------ 426 fission yeast
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