Conserved Protein Domain Family
CYP306A1-like
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cd20652: CYP306A1-like 
cytochrome P450 306A1 and similar cytochrome P450s
This subfamily is composed of insect and crustacean cytochrome P450s including insect cytochrome P450 306A1 (CYP306A1 or Cyp306a1) and CYP18A1. CYP306A1 functions as a carbon 25-hydroxylase and has an essential role in ecdysteroid biosynthesis during insect development. CYP18A1 is a 26-hydroxylase and plays a key role in steroid hormone inactivation. The CYP306A1-like subfamily belongs to the large cytochrome P450 (P450, CYP) superfamily of heme-containing proteins that catalyze a variety of oxidative reactions of a large number of structurally different endogenous and exogenous compounds in organisms from all major domains of life. CYPs bind their diverse ligands in a buried, hydrophobic active site, which is accessed through a substrate access channel formed by two flexible helices and their connecting loop.
Links
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Statistics
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PSSM-Id: 410745
Aligned: 7 rows
Threshold Bit Score: 693.384
Created: 16-Jul-2019
Updated: 25-Oct-2021
Structure
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Aligned Rows:
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heme bindingputative
Feature 1:heme binding site [chemical binding site]
Evidence:
Scroll to Sequence Alignment Display
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1                                      #                      #   #                   
Q9VWR5     81 GGIFELKMGrvPTVVLSdAALVRDFFRRDvmTGRAPLYLTHGIMGgfgiicaqedIWRHARRETIDWLKALGMtrrpgel 160 fruit fly
BAH24005   72 GRVYSLKMGgvSVVVIAdPDLIRETFNQKitTGRAPLYLTHGIMKgyglicaegdLWRDHRKFVLGFMRHHGMkntgs-- 149 Marsupenaeus japon...
AAB69750   85 GSLFSTRLGsqLTVVMSdYKMIRECFRREefTGRPDTPFMQTLNGygiin-stgkLWKDQRRFLHDKLRQFGMtymgn-g 162 fruit fly
EDS27410   74 GPIFGLHMGqvYAVVLTdPSLIRDALKREelTGRAPLFITHGIMGgqgiicaegnLWRDQRRLSSEWLRKMGMtkfgp-a 152 southern house mos...
BAD34476   60 GAIYGLKMGsiYAVVLSdHKLVRDTFSKDsfSGRAPLYLTHGLMNgngiicaeggLWRDQRKLITSWLKSFGMskhsv-s 138 domestic silkworm
EEB14712   63 GKIYSIQMGniFTVVLSdVKLVRQALAMDifTGRAPLYLTHGIMKdngiicvqgeKWKEQRKFVVNNLRNFGMvkfatkk 142 human body louse
Q95078     85 GSLFSTRLGsqLTVVMSdYKMIRECFRREefTGRPDTPFMQTLNGygiin-stgkLWKDQRRFLHDKLRQFGMtymgn-g 162 fruit fly

Feature 1                                                                                     
Q9VWR5    161 rarlERRIARGVDECVRLFDteakkscasevnPLPALHHSLGNIINDLVFGitykrddPDWLYLQRLQEEGVKLIGVSGV 240 fruit fly
BAH24005  150 rgamEPRIHEVGAQLTKELAqese-----gvdISGKLMHHVGNTMNQLIFGftykeddGTWRWLRYLLEEGTKLVGIAGP 224 Marsupenaeus japon...
AAB69750  163 kqqmQKRIMTEVHEFIGHLHasdg----qpvdMSPVISVAVSNVICSLMMStrfsiddPKFRRFNFLIEEGMRLFGEIHT 238 fruit fly
EDS27410  153 ratlEARIVAGVNELVQDLKaesek--vfafdPAPFVHHILGNLLNDLVFGlrydrddETWRYLQHLQEEGVKHIGVSMA 230 southern house mos...
BAD34476  139 reklEKRIASGVYEILENIEktsd----aaldLPHMLTNSLGNVVNEIIFGfkfppedKTWQWFRQIQEEGCHEMGVAGV 214 domestic silkworm
EEB14712  143 rdkmEEGIRCGVEELIKKIKtreg----kplnVEHLLMHTLGNVVFNLVFGkvwnendETWKKLINLQEEGTKLIGVAGP 218 human body louse
Q95078    163 kqqmQKRIMTEVHEFIGHLHasdg----qpvdMSPVISVAVSNVICSLMMStrfsiddPKFRRFNFLIEEGMRLFGEIHT 238 fruit fly

Feature 1                                                                                     
Q9VWR5    241 VNFLPwlrhl---panvrNIRFLLEGKAKTHAIYDRIVEACGQRLKEKqkvfkelqeqkrlqrqlekeqlrqskeadpsq 317 fruit fly
BAH24005  225 LNFLPclryl---pqykhIFSFITDNQRKTHAEYQKIISAHEEDLLREaaaqaagdetssddeakdtpr----------- 290 Marsupenaeus japon...
AAB69750  239 VDYIPtmqcf---psistAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNnirdlvdfylceieka---------------- 299 fruit fly
EDS27410  231 VNFLPflralpedagdggDQEGKVNDPANGDCILTNFVQETRRREAAGrpel---------------------------- 282 southern house mos...
BAD34476  215 VNFLPfirhvs--pstrkTIEVLVRGQAQTHTLYASMIDRRRKMLGLEkpkgaeyaphenllklypnghikcikyskvsp 292 domestic silkworm
EEB14712  219 INFLPflrfl---pkykkVIKYLKTGIEYSHDIYQKILQEYKKNEKSMdddniepeidhflgaf---------------- 279 human body louse
Q95078    239 VDYIPtmqcf---psistAKNKIAQNRAEMQRFYQDVIDDHKRSFDPNnirdlvdfylceieka---------------- 299 fruit fly

Feature 1                                                         #  ##  ##  #                
Q9VWR5    318 eqse---adeddeesdeedtyepecilehflavrdtdsqlycDDQLRHLLADLFGAGVDTSLATLRWFLLYLAREqrCQR 394 fruit fly
BAH24005  291 ---------------------hivdayvkkrrqlgenvgsftYKQLHHVAADLFGAGSETTITTLKWHLLNMALFpdIQT 349 Marsupenaeus japon...
AAB69750  300 ---------------------------kaegtdaelfdgknhEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNpkEMR 352 fruit fly
EDS27410  283 --------------------------------------afcsDAQLRHLLADLFGAGVDTTFTSLRWLLLFVGLDrdVQQ 324 southern house mos...
BAD34476  293 ntehffdpntliptegdcildnflleqkkrfesgdptalymrDEQLHFLLADMFGAGLDTTSVTLAWFLLYMALFpeEQE 372 domestic silkworm
EEB14712  280 ---------------------------hwemekrkneksfytNYQFNYLMADLWGAGVDTTITTLRWFLFYVAHDdkIQK 332 human body louse
Q95078    300 ---------------------------kaegtdaelfdgknhEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNpkEMR 352 fruit fly

Feature 1                                        #    #   ## #                      #         
Q9VWR5    395 RLHELLLPlgpsptl----eeleplAYLRACISETMRIRSVvpLGIPHGCKENFVVgdYFIKGGSMIVCSEWAIHMDpva 470 fruit fly
BAH24005  350 RIQRELDErakgrdyv-tlgegedlPFTQAAIMESQRLRSVvpLGIPHGVSQELRVagYRVPRDTMILPLLWFVHHNpdt 428 Marsupenaeus japon...
AAB69750  353 RVQDELDQvvgrhrlp-tiedlqylPITESTILESMRRSSIvpLATTHSPTRDVELngYTIPAGSHVIPLINSVHMDpnl 431 fruit fly
EDS27410  325 RLRRELCAlqreptl----ndmdslPYLKACVAEAQRLRTVvpLGIPHGTVSDTNIagFKIPKGAMIMPVLWAVHMNpdl 400 southern house mos...
BAD34476  373 EIRKEILSvypyddd----vdssrlPLLMAAICETQRIRSIvpVGIPHGCIEDAYLgnYRIPKNAMVIPLQWAIHMDpnv 448 domestic silkworm
EEB14712  333 NIQNEIDEvlgdvktvitlddisslPYFQACISECQRIRSVtpLGIPHGSLEDAVLdgYHIPKGTMIIPLQWAIHMNssy 412 human body louse
Q95078    353 RVQDELDQvvgrhrlp-tiedlqylPITESTILESMRRSSIvpLATTHSPTRDVELngYTIPAGSHVIPLINSVHMDpnl 431 fruit fly

Feature 1                               ###   #####  ##   #                                   
Q9VWR5    471 fpePEEFRPERFLTADGayqappqFIPFSSGyRMCPGEEMARMILTLFTGRILRRFHlELPSGTEVDmag--esGITLTP 548 fruit fly
BAH24005  429 wpdPELYRPERFLDTEGrvlkhpaFMPFQTGrRRCIGDEFAMMIMFIFTTRILLKFRiKLEDELKGDpsqepvcGITLSP 508 Marsupenaeus japon...
AAB69750  432 wekPEEFRPSRFIDTEGkvrkpeyFIPFGVGrRMCLGDVLARMELFLFFASFMHCFDiALPEGQPLPslk-gnvGATITP 510 fruit fly
EDS27410  401 wsdPDRYNPEHFLDESGqyvapahFLPFQTGkRMCLGDELARMILYLYTARIFWHFElDVFDGKAVDltg--icGITLAP 478 southern house mos...
BAD34476  449 weePEKFKPRRFLAQDGsllkpqeFIPFQTGkRMCPGDELSRMLSCGLVSRLFRKQRiRLASKIPTAeemrgtvGVTLAP 528 domestic silkworm
EEB14712  413 ynePNVFDPTRFLDDDGkykkpeaFIPFQTGkRMCLGEEYAKMLLFLFAGAILNNFHlSLDYYEDFEge----pGITLTP 488 human body louse
Q95078    432 wekPEEFRPSRFIDTEGkvrkpeyFIPFGVGrRMCLGDVLARMELFLFFASFMHCFDiALPEGQPLPslk-gnvGATITP 510 fruit fly

Feature 1          
Q9VWR5    549 TPHML 553 fruit fly
BAH24005  509 RPFKL 513 Marsupenaeus japonicus
AAB69750  511 ESFKV 515 fruit fly
EDS27410  479 PAYEI 483 southern house mosquito
BAD34476  529 PPVKY 533 domestic silkworm
EEB14712  489 KKHLI 493 human body louse
Q95078    511 ESFKV 515 fruit fly

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