Conserved Protein Domain Family
RING-HC_RNF182
?
cd16555: RING-HC_RNF182 
RING finger, HC subclass, found in RING finger protein 182 (RNF182) and similar proteins
RNF182 is a brain-enriched E3 ubiquitin-protein ligase that stimulates E2-dependent polyubiquitination in vitro. It is upregulated in Alzheimer"s disease (AD) brains and neuronal cells exposed to injurious insults. It interacts with ATP6V0C and promotes its degradation by the ubiquitin-proteosome pathway, suggesting a very specific role in controlling the turnover of an essential component of the neurotransmitter release machinery. RNF182 contains an N-terminal C3HC4-type RING-HC finger, and a C-terminal transmembrane domain.
Links
?
Statistics
?
PSSM-Id: 438217
Aligned: 8 rows
Threshold Bit Score: 85.9511
Created: 26-Jul-2013
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
Download Cn3D
 
Zn binding site
Feature 1: Zn binding site [ion binding site], 8 residue positions
Conserved feature residue pattern:C C C H C C C CClick to see conserved feature residue pattern help
Evidence:
  • Comment:based on the structures of other RING-HC fingers with bound zinc
  • Comment:C3HC4-type RING-HC finger consensus motif: C-X2-C-X(9-39)-C-X(1-3)-H-X(2-3)-C-X2-C-X(4-48)-C-X2-C, where X is any amino acid and the number of X residues varies in different fingers
  • Comment:A RING finger typically binds two zinc atoms, with its Cys and/or His side chains in a unique "cross-brace" arrangement.
Scroll to Sequence Alignment Display
Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection: 
Feature 1           #  #               # #  #  #                 #  #    
Q8N6D2        17 ELECKICYNRYNLKqRKPKVLECCHRVCAKCLYKIIDFGDSpq-gVIVCPFCRFET 71  human
Q6INB3        19 ELECKICYNRYNLRqRKPKVLGCCHRVCAKCLYKLVDCGESpq-cVIVCPFCRFET 73  African clawed frog
EMP28285      20 ELECKICYNRYDARaRKPKLLSCCHRVCAKCLRKMVAVGESsp-hLLSCPFCRQET 74  green seaturtle
XP_007900860  19 ELECKICYSPYNLRnRRPKVLECLHRVCGKCLYKIVDLGDSss-sIICCPFCRYET 73  elephant shark
NP_001038816  17 ELECKICYCAYSLSsRRPKVLKCCHCLCAKCLAKIHDLGESsp-nAVICPFCRYIT 71  zebrafish
XP_006013653  19 ELECKICYNRYNLRhRRPKVLECCHRVCSKCLCKIIDSGDSpq-sVIVCPFCRFET 73  coelacanth
XP_018093339  17 ELECKICYNGFDAKqHRPKVLGCDHRLCARCLRKMAHTWGPgpptSLCCPFCRQET 72  African clawed frog
XP_015152061  65 EPECQICYSRYDARtRRPAELLCGHRLCARCLSRMVALGDAsp-rRLRCPFCRRRS 119 chicken

| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap