Conserved Protein Domain Family
CCDC85

?
pfam10226: CCDC85 
CCDC85 family
This entry includes human CCDC85A/B/C and C. elegans Picc-1 protein. Picc-1 serves as a linker protein which helps to recruit the Rho GTPase-activating protein, pac-1, to adherens junctions. Human CCDC85B suppresses the beta-catenin activity in a p53-dependent manner.
Statistics
?
PSSM-Id: 463009
Aligned: 13 rows
Threshold Bit Score: 227.747
Created: 23-Mar-2022
Updated: 17-Oct-2022
Structure
?
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
?
Format: Row Display: Color Bits: Type Selection:
XP_023183633  28 AEDVAKIPDEELLKWSKQELVRRLRQTETEKRAVIVEHGNLMREVNRRLQQHLTEIRSLKDVNQKLQ-------EDNQEL 100
1_pfamImport   1 AEDSSNMSDEELLTRGKEELVRWLRRAEAGKRSAIMDHGDRMREVNRRLQQHLNEIRSLKDVNQKLQ-------EDNQEL 73 
XP_011601483  15 TEELSKISDEELLKWSKEELVRRLRRAEMEKRGVIVEHGNLMREVNRRLQQHLNEIRSLKDVNQKLQ-------EDNQEL 87 
Q15834         5 AGGLEELTDEEMAALGKEELVRRLRREEAARLAALVQRGRLMQEVNRQLQGHLGEIRELKQLNRRLQ-------AENREL 77  human
XP_015194332  10 QRELGRLSDEDLLRSSKEELVARLRREEADKIAALLQRGRLIAEVNRQLQGHLLEVRELKAVNQRLQ-------QDNREL 82 
A2CEM9         9 NRELSKLSDEDLLACTKEELVNRLRKEESDKMSALIQRGRLIKEVNKQLQGHLLEIRELKVINQRLQ-------EENQEL 81  zebrafish
XP_022528990  10 RDDLSKISDEELFRLSKDELVRRLRKVDSEKMSLMVEHGNMIKDVNRRLQVHLHEIRGLKEVNQKLQ-------DDNQEL 82 
XP_001374725  11 KEDLSKVPDEELLRWSKEELARRLRRAEGEKMGLMVEHGNLMKDVNRRLQLHLHEIRGLKEVNQKLQ-------DDNHEL 83 
XP_012663047   9 SKDLSQVPDEELLRWSKVELARRLRYAQGEKVGLMLEHRGLLRHVNRRLHQHLLEIRSLKDVNQRLQ-------DDNQEL 81 
XP_011477970  23 AEDISGITDEDLLKWTKEDLVRRLRRSEADKMSVILDHGNLIREVNRSLQLHLNEIRGLKDINQKLQ-------EDNREL 95 
NP_001307120  21 SEDLSKLTDEELLKWSKEELVRRLRRAEAEKMSVIVDHSNLIREVNRRLQQHLNEIRGLKEVNQKLQ-------EDNQEL 93 
XP_026696207  26 GCLRS-PTDIELRHEGLDHVIQRLRFAENENKKLLVERSRAMKDVNRKLQVHLLEVRGVREVNQKLMlekdallKEKEEL 104 vase tunicate
XP_027428658  12 SEELSQVPDEELLRWSKEELARRLRRAEGEKVGLMLEHGGLMRDVNRRLQQHLLEIRGLKDVNQRLQ-------DDNQEL 84  California sea ...
XP_023183633 101 RDLCCFLDDDRQKGKRVSREWQRLGRFSAGLMRKEVAVYLQKLKELEQRQMEVVQENLELKEVCFMLEEERAAataggg- 179
1_pfamImport  74 RDLCCFLDDDRQKGKRVSREWQRLGRYSAGLMRKEVSIYLQKLKELEQRQVEVVRENLELKEVCLMLDEERAAvggh--- 150
XP_011601483  88 RDLCCFLDDDRQKGKRVSREWQRLGRYSASLMRKEVAIYLQKLKELEQRQVEVIRENLELKEVCLMLEEERVMtaag--- 164
Q15834        78 RDLCCFLDSERQRGRRAARQWQLFGTQASRAVREDLGGCWQKLAELEGRQEELLRENLALKELCLALGEEWGP------- 150 human
XP_015194332  83 RDLCCFLDDDRLKAKRLAREWQLFGQHAARVLRDDLGGYLQKLAELERLQGALLRENLDLKELCLVLEEECVG------- 155
A2CEM9        82 RDLCCFLDDDRLKVKKLAREWQLFGHHAAKVMREDLGGYLKKLADLERMQDGLVKENLDLKELCLVLEEECVS------- 154 zebrafish
XP_022528990  83 RELCCFLDDDRQKGKKLSREWQRFGRYTASVMWKEVGVYQQKLKELEANQDTIMRENMELKEIILMLEEERSG------- 155
XP_001374725  84 RELCCFLDDDRQKGKKLSREWQRFGRHTAGVLWKEVALSQQKLRELEARQEALLRENLELKEIVLMLDEERSg------- 156
XP_012663047  82 RELCCFLEDDRQKGRKLAREWQNFGRHAADAVWHEVARSQQKLRELEARQEALLCENLELKELVLLLDEERTSlaaagga 161
XP_011477970  96 RDLCCFLDDDRQKGKRVSREWQRLGRYSASIMRKEVTLYLQKLKELELRQEEVIRENLELKELCLLLDEEKGGsfvggnl 175
NP_001307120  94 RDLCCFLDDDRQKGKKVSREWQRLGRYSAGIMRKEVTLYLQKLKELEQRQEEVVRENLELRELCLMLDEEKGSggtsgs- 172
XP_026696207 105 AGICCFLDDDREKAKKVAREWQMFGRYATGVLQKELATCHQKIKDLELKQTTLVQENKTLKEICLMLDQENAG------- 177 vase tunicate
XP_027428658  85 RELCCFLDDDRQKGRKLAREWQRFGRHAAGAVWHEVARSQQKLRELEARQEALLRENLELKELVLMLDEEraalaggggg 164 California sea ...
XP_023183633 180 -ahtqgdPGCRSSIDSQNSLSQ-LGGGGPTPGl-LRDVGDGSSTSSAGSTDSPDK 231
1_pfamImport 151 ---avggPGRRSSIDSQSSLSQ-LGGTLPAPGl-LRDVGDGSSTSSGGSTDSPDN 200
XP_011601483 165 ---ggggLGRRSSVDSQSS-SQ-LCGSGPAPGl-LRDVGDGSSTSSAGSTDSPDN 213
Q15834       151 ----------RGGPSGAGGSGAgPAPELALPPcgPRDLGDGSS--STGSVGSPDQ 193 human
XP_015194332 156 ----------RAEGSPAGS------SELSLPCl-ARDLGDGSS--STGSVGSPDQ 191
A2CEM9       155 ----------RSDSSPGGS------TDLNIPCmvARDVGDGSS--STGSVGSPDQ 191 zebrafish
XP_022528990 156 -------AGSRSSIDSQSSLTN-LNGGSSN----MRDVGDGSSTSSTGSAGSPDH 198
XP_001374725 157 -------AGSRSSIDSQASLTN-LAGGSGGAG--PRDVGDGSSTSSTGSGGSPDH 201
XP_012663047 162 -gsggggAGALISIHSQASLSGpLVGGAAGAR--ARDVGDGSSTLSTGSGGSPDH 213
XP_011477970 176 sggntgmGGCRNSIDSQNSLLL-VPGQGLL----MRDVGDGSSTSSAGSADSSDH 225
NP_001307120 173 -vgtggpAGCRNSIDSQSSLSH---ASGPGPGl-LRDVGDGSSTSSAGSTDSPDH 222
XP_026696207 178 ---------NRSSVDSQSSFPPpPN-LLHTPE--TRDSGDGSSNGSTASNYSPDH 220 vase tunicate
XP_027428658 165 agggsgggggggggagsrssidsqaslsgplaggaagagardvgdgsstssagsg 219 California sea lion
| Disclaimer | Privacy statement | Accessibility |
NCBI Home NCBI Search NCBI SiteMap