1REQ


Conserved Protein Domain Family
mmCoA_mut_beta

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TIGR00642: mmCoA_mut_beta 
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methylmalonyl-CoA mutase, heterodimeric type, beta chain
The adenosylcobalamin-binding, catalytic chain of methylmalonyl-CoA mutase may form homodimers, as in mitochondrion and E. coli, or heterodimers with a shorter, homologous chain that does not bind adenosylcobalamin. This model describes this non-catalytic beta chain, as found in the enzyme from Propionibacterium freudenreichii, for which the 3-dimensional structure has been solved. [Central intermediary metabolism, Other]
Statistics
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PSSM-Id: 273191
Aligned: 4 rows
Threshold Bit Score: 840.367
Created: 7-Oct-2014
Updated: 25-Oct-2021
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
1REQ_B    20 LSLAGDFpKATEEQWEREVEKVLNRGRPPEKQLTFAECLKRLTVHTVDGIDIVPMYRPK---DAPKKLGYPGVAPFTRGT 96  Propionibacterium f...
P71773     5 VPERADL-EQVRGRWRNAVAGVLSKSNRTDSAQLGDHPERLLDTQTADGFAIRALYTAF---DELPEPPLPGQWPFVRGG 80  Mycobacterium tuber...
AAB51083   6 eKLFSEFpPVSREAWIDKITADLK----------GVPFEKKLVWRTNEGFNVNPFYRREdieDLKTTTSLPDEYPYVR-- 73  Porphyromonas gingi...
CAA33089  21 LSLAGDFpKATEEQWEREVEKVLNRGRPPEKQLTFAECLKRLTVHTVDGIDIVPMYRPK---DAPKKLGYPGVAPFTRGT 97  Propionibacterium f...
1REQ_B    97 TVRNGDMDAWDVRALH-EDPDEKFTRKAILEGLERGVTSLLLRVDPDAIAPEHLDEVLSDVLLEMTKVEVFSRYDQGAAA 175 Propionibacterium f...
P71773    81 DPLRDVHSGWKVAEAFpANGATADTNAAVLAALGEGVSALLIRVGESGVAPDRLTALLSGVYLNLAPVILDAGADYRPAC 160 Mycobacterium tuber...
AAB51083  74 STR--MHNEWLVRQDIvVGDNVAEANEKALDLLNKGVDSLGFYLKKVHINVDTLAALLKDIELTAVELNFNCCITRAADL 151 Porphyromonas gingi...
CAA33089  98 TVRNGDMDAWDVRALH-EDPDEKFTRKAILEGLERGVTSLLLRVDPDAIAPEHLDEVLSDVLLEMTKVEVFSRYDQGAAA 176 Propionibacterium f...
1REQ_B   176 EALVSVYERSD-KPAKDLALNLGLDPIGFAALQG-TEPDLTVLGDWVRRLAKFspDSRAVTIDANIYHNAGAGDVAELAW 253 Propionibacterium f...
P71773   161 DVMLALVAQLDpGQRDTLSIDLGADPLTASLRDRpAPPIEEVVAVASRAAGER--GLRAITVDGPAFHNLGATAATELAA 238 Mycobacterium tuber...
AAB51083 152 LSAFSAYVKKVgADPNKCHGSVSYDPFKKQLVRGvSNPDWVKMTLPVMDAARElpAFRVLNVNAVNLSDAGAFITQELGY 231 Porphyromonas gingi...
CAA33089 177 EALVSVYERSD-KPAKDLALNLGLDPIAFAALQG-TEPDLTVLGDWVRRLAKFspDSRAVTIDANIYHNAGAGDVAELAW 254 Propionibacterium f...
1REQ_B   254 ALATGAEYVRALVEQGFTATEAFDTINFRVTATHDQFLTIARLRALREAWARIGEVFGVd--EDKRGARQNAITSWRELT 331 Propionibacterium f...
P71773   239 TVAAAVAYLRVLTESGLVVSDALRQISFRLAADDDQFMTLAKMRALRQLWARVAEVVGD---PGGGAAVVHAETSLPMMT 315 Mycobacterium tuber...
AAB51083 232 ALAWGAELLDKLTDAGYKPEEIASRIKFNFGIGSNYFMEIAKFRAARWLWAQIVGSYGDqykNETAKIHQHATTSMWNKT 311 Porphyromonas gingi...
CAA33089 255 ALATGAEYVRALVEQGFTATEAFDTINFRVTATHDQFLTIARLRALREAWARIGEVFGVd--EDKRGARQNAITSWRDVT 332 Propionibacterium f...
1REQ_B   332 REDPYVNILRGSIATFSASVGGAESITTLPFTQAL--GLP--EDDFPLRIARNTGIVLAEEVNIGRVNDPAGGSYYVESL 407 Propionibacterium f...
P71773   316 QRDPWVNMLRCTLAAFGAGVGGADTVLVHPFDVAIpgGFPgtAAGFARRIARNTQLLLLEESHVGRVLDPAGGSWFVEEL 395 Mycobacterium tuber...
AAB51083 312 VFDAHVNLLRTQTETMSAAIRGVDSITVLPFDVTYq--QS---DDFSERIARNQQLLLKEECHFDKVIDPSAGSYYIETL 386 Porphyromonas gingi...
CAA33089 333 REDPYVNILRGSIATFSASVGGAESITTLPFTQAL--GLP--EDDFPLRIARNTGIVLAEEVNIGRVNDPAGGSYYVESL 408 Propionibacterium f...
1REQ_B   408 TRSLADAAWKEFQEVEKLGGMSKAVMteHVTKVLDACNAERAKRLANRKQPITAVSEFPMIGars------ietKpfPAA 481 Propionibacterium f...
P71773   396 TDRLARRAWQRFQAIEARGGFVEAHD--FLAGQIAECAARRADDIAHRRLAITGVNEYPNLG------------E--PAL 459 Mycobacterium tuber...
AAB51083 387 TNSIGEEAWKLFLSVEDAGGFTQAAEtaSIQKAVNASNIKR-PVGATRREIFLGTNQFPNFTevagdkitlaqgEhdCNC 465 Porphyromonas gingi...
CAA33089 409 TRSLADAAWKEFQEVEKLGGMSKAVMteHVTKVLDACNAERAKRLANRKQPITAVSEFPMIGars------ietKpfPAA 482 Propionibacterium f...
1REQ_B   482 PARKGLAWHRDSEV-FEQLMDRS----TSVSERPKVFLACLGTRRDFGGREGFSSPVWHIAGIDTPqVEGGTTAEIV-EA 555 Propionibacterium f...
P71773   460 PPGDPTSPVRRYAAgFEALRDRSdhhlARTGARPRVLLLPLGPLAEHNIRTTFATNLLASGGIEAI-DPGTVDAGTVgNA 538 Mycobacterium tuber...
AAB51083 466 VKSIEPLNFSRGASeFEALRLAT----EKSGKTPVVFMLTIGNLAMRLARSQFSSNFFGCAGYKLIdNLGFKSVEEGvDA 541 Porphyromonas gingi...
CAA33089 483 PARKGLAWHRDSEV-FEQLMDRS----TSVSERPKVFLACLGTRRDFGGREGFSSPVWHIAGIDTPqVEGGTTAEIV-EA 556 Propionibacterium f...
1REQ_B   556 FKKSG-AQVADLCSSAKVYAQQGLEVAKALKAAGAKALYLSGAFKEFGDDAAEaeklIDGRLFMGMDVVDTLSSTLDILG 634 Propionibacterium f...
P71773   539 VADAGsPSVAVICGTDARYRDEVADIVQAARAAGVSRVYLAGPEKALGDAAHR----PDEFLTAKINVVQALSNLLTRLG 614 Mycobacterium tuber...
AAB51083 542 ALAAK-ADIVVLCSSDDEYAEYAP--AAFDYLAGRAEFVVAGAPACMADLEAKg---IRNYVHVKSNVLETLRAFNDKFG 615 Porphyromonas gingi...
CAA33089 557 FKKSG-AQVADLCSSAKVYAQQGLEVAKALKAAGAKALYLSGAFKEFGDDAAEaeklIDGRLFMGMDVVDTLSSTLDILG 635 Propionibacterium f...
1REQ_B   635 V 635 Propionibacterium freudenreichii subsp. shermanii
P71773   615 A 615 Mycobacterium tuberculosis
AAB51083 616 I 616 Porphyromonas gingivalis
CAA33089 636 V 636 Propionibacterium freudenreichii subsp. shermanii
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