Conserved Protein Domain Family
MAGE

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pfam01454: MAGE 
MAGE homology domain
The MAGE (melanoma antigen-encoding gene) family are expressed in a wide variety of tumours but not in normal cells, with the exception of the male germ cells, placenta, and, possibly, cells of the developing embryo. The cellular function of this family is unknown. This family also contains the yeast protein, Nse3. The Nse3 protein is part of the Smc5-6 complex. Nse3 has been demonstrated to be important for meiosis.
Statistics
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PSSM-Id: 426270
Aligned: 98 rows
Threshold Bit Score: 81.9335
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
ESK91814      68 LVRLA-LFNENRRGPLRRDDISKkVMGGn--------ARIFNRVFEQANATLKKTFGMELVELPSKasleeeatgtvedA 138
CCK70997      22 VVRFLlSNAEASNGIVTKSRLQV-VVRTvseqlnndrKIPMRVIIEHVNGILWDVYGFRLLGIPPR-------------G 87 
Q6FSE8        24 LVGFIlSSTEQGNSVLGRAKLQK-AIKQyasn-envvRCPMSDVLLKVNQILDDTYGFELIGVSTN-------------K 88  [Candida] glabrata
XP_002619647  49 LLRMV-MTRSARNQKIRREHFTA-ILHKhn------vKGNTKAIISQVDAELKEVFGLKLDQS----------------- 103
XP_007372871  44 VIRLV-LTRESKGQLIRREHINQ-IINDr-------kNRSYDVVLKEVTVALEEAYGLTLVETPII-------------K 101
XP_002545705  63 VVRLA-LAKELNGKKLRTDHIAK-AIKHnf-----grKVTGNVLIKEANKILQEVYGLSLEDVSSS-------------T 122
EMG48242      60 VVRLF-LTRELLGKPSKPDVIRK-FVKHnl-----grKFTTDMLIQQADVVLKDVYGLAIQETPNL-------------N 119
CCE41206      84 IVKLI-LTKDARGQNFQKQHINQyLTNK---------RFKSDSLLDDAIAILENVYGLTLVDAPTA-------------K 140
Q6BHM0        43 VIRYV-MSRELKSQIIRREHITQ-LYSNr--------RINYDALITRVKLTLKEVYGLTLVVVPPK-------------R 99  Debaryomyces ha...
XP_001384110  11 VVRLI-LGRELKSQFIRREKISSeVNTK---------RHGLDLIIKRVNAELEKVYGLTLVETPPE-------------K 67 
ESK91814     139 ELEEARKAVGGKKKa---tTVG-----------------SKQYIIRSILDPGLLdyaslmhesilNQEAEDLPSDDdddd 198
CCK70997      88 ESSTAQPALADps-------------------------kADHFLLVNKLPWrk----------hfDEFKLSQVSSTydkl 132
Q6FSE8        89 TTSQADQSGRStpiaiads------------tksikssdINYFVLRNKLKPit----------avENFKIELAKEAyetf 146 [Candida] glabrata
XP_002619647 104 ---------------------------------------TNDIVLVSNLQKDTKlllqklvengdGSEFKGNPYdtfyfm 144
XP_007372871 102 KKGDTSKAKKVLK--------P-----------------KQPYAVVNCLTPEARnllgdiwekslGT-FTKNDDLGqskf 155
XP_002545705 123 DKQKTKPESDQPATkm-rkTSG-----------------KGPYVMVSTLSVQSRnilgelwnkdlRI-SFKKPDLTskgf 183
EMG48242     120 NAKKQDQQQQQPQQtqeqqPKKprka----------ageRNAFIVVSDLSPQARnvlgelwqrdlAR-VTKKTDINtskf 188
CCE41206     141 QEKKFNASHGDQRNvidtsNANggvnggngdkitkktppRNRFFLVSNLSQPAQqvlgdlwmttvNS-SLDKTKIGdtrf 219
Q6BHM0       100 GDKKNKSSHSNG---------------------------KQQLMLTNCLSPEGRivlqeiwltdsEAGIPNNRNSGdnqy 152 Debaryomyces ha...
XP_001384110  68 KSRVTKTTNVKV---------------------------KQPFAIVSCLEPKSKkvlgelwqtstNVNPEADAHgskyfv 120
ESK91814     199 sgirsygs--------------------ifswstcdqleAYGVLTVILSLILVSGKVMSDADLRNALKHLHLNNSSqirf 258
CCK70997     133 ivdgeyvggemsl---------sdataagtklgvdedlvCKGLTAVALSIILFSRNNIVQRELLHHLSEFGIPIDGt--- 200
Q6FSE8       147 lskelgenedynsdgeniipqsqinatlssdyeikdnlvLKGILSVMLCIILFSKNNLLERDLYEELKKFGISENN---- 222 [Candida] glabrata
XP_002619647 145 nkekr-----------------------nettvsmsdsiFGGIIMLLIGLVIVNENRIRESDLLDGLSQFGFSENLn--- 198
XP_007372871 156 yvprysk---------------------sklptsnyelvKNGILLVIVSLIILSENHISESELFRNLRKFGISTNLn--- 211
XP_002545705 184 flplyek---------------------tpapgshydlvKTGIMLLIISMIILNENHIQETILLTKLKKFGISDNLn--- 239
EMG48242     189 flpkynk---------------------scipgshhqlvKDGIMLVIISIIILNENHIQEDALLKSLRKVGLPPSLn--- 244
CCE41206     220 flpkfkq---------------------silpksnsdlvKTGIMMLVTTLVILSENHIMESQLIRSLRKFGISDNNa--- 275
Q6BHM0       153 flpkynk---------------------tsslgsntdmvKTGVTLLIMSLLIISENHMSEYELVNGLKRFGLSDHPn--- 208 Debaryomyces ha...
XP_001384110 121 pkykk-----------------------tegplsnielvRTGIMLYIVSMLILAENYLSEDDLERGMERMGISKDSn--- 174
ESK91814     259 taLSTTRTMPLDRFLDSLMRQGYIDQQIVgeakkkggpgkrarqaDDDTGVQYEWRWGPRAH 320
CCK70997     201 --rIPILEWSIDEFLRWLERREYVVRAQDk---------------TDLEGSSTLYRTGRRTQ 245
Q6FSE8       223 --PIPLLDMSIDSVLRIFVNQQYIDKRDQn---------------TETGNVITTYHIGRRTK 267 [Candida] glabrata
XP_002619647 199 -iVVPNLNKTTQEVLTEATKKEYLQKLVAq--------------aHGGEPAIVSYALGKRTL 245
XP_007372871 212 -vKNSSLNMNIQELLNDLIRREYLNKNITk--------------gRIESENVVEYTLGRRSL 258
XP_002545705 240 -qKNSNINMNSKDLLNDLTDKEYLSRKKLk--------------gRTESEDIHDYSLGKRSL 286
EMG48242     245 -vKNSNLNMNTVELIKELKDHDYLSENVIk--------------gSSESENIIDYSLGKRSL 291
CCE41206     276 -mKNSNINMNWEDVLKELVSREYLTKLQLa---------------DSEKDKIYAISLGRRSL 321
Q6BHM0       209 -fKNSSFNASLPDLINELVKKEYLDKEVQk---------------DSNNVENVDYKLGRRSL 254 Debaryomyces hansenii
XP_001384110 175 -kRNSNLGMNLQELVSDLIKKDYINKEVSk--------------gTVESENRVIYSLGRRSL 221
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