6O55,3OOW,3LP6,5C5D,3TRH


Conserved Protein Domain Family
AIRC
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pfam00731: AIRC 
AIR carboxylase
Members of this family catalyze the decarboxylation of 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR). This family catalyze the sixth step of de novo purine biosynthesis. Some members of this family contain two copies of this domain.
Links
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Statistics
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PSSM-Id: 459917
Aligned: 595 rows
Threshold Bit Score: 88.9641
Created: 21-Mar-2022
Updated: 17-Oct-2022
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6O55_A         14 IGLIMGSQSDWQTLIHAAHTLDA---LNIGY-EAEIVSAHRTPDKLFRYAEQAEARG-LEVIIAGAGGAAHLPGMVAAKT 88  Legionella pne...
XP_001951651  270 VVVVMGSSSDESFGKKIAEYTKNv--MGINT-EIRIGSAHKSTEFVLKMIDKYEGLRiPVVIVAVAGRSNGLGPVIAGYT 346
XP_011674663  270 VVVLMGSASDIPHGEKIKNECSS---FGLHC-DLRVTSAHKGTDETLRILKYYESLGiPAVFIAVAGRSNGLGPVLSGNA 345
XP_001622041  265 VVVFMGSASDIDHCKKIEAALKS---FNVPC-DLRVSSAHKGSEDTLKVLRVYEGQGvPIVIIAVAGRSNGLGPVLSGNT 340
XP_011434632  266 aVVFMGSASDMPHCEKIRTSCQQ---LGVPC-ELRVSSAHKGTEETMKILAEYEGEGiPTVFIAVAGRSNGLGPVLSGNA 341
XP_002407164  196 VAVVMGSPSDKEHCEKIKKACEK---LGVPC-ELRVASAHKNTDQSLDLIAEYEGEGiPTVFVSVAGRSNGLGPVTSGNS 271
XP_015783892  288 VGIILGSMSDMEHAQKIKKALSEk--YGINDvEIHVCSAHKSTEATLTVLASLMQWPtCQVIIACAGRSNGLGPVSAGNT 365
jgi:Mmah_0804 122 VAIISAGTADINVAEEARMTAAEmgcETVKIyDVGVAGLHRLLNEVKNLESDRPD-----AVVVAAGREGTLPTVVSSLF 196
XP_027826817  268 VIVLMGSTSDLSHCEKIKKACGT---FGIPC-ELRVTSAHKGPDETLRIKAEYEGDGiPTVFVAVAGRSNGLGPVLSGNT 343 sheep
XP_014346374  683 VVVLMGSTSDLGHCEKIKKACAN---YGIPC-DLRVTSAHKGPDETLRIKAEYEGDGvPTVFVAVAGRSNGLGPVMAGNT 758 coelacanth

6O55_A         89 SLPVLGVPVMSqtl---ngvDSLLSIVQMPAGIPVGTLSIGkaGAINSALFAAAILANKYPDIRAALKHYREQQ 159 Legionella pneumophi...
XP_001951651  347 NLPVINCPPLNatn----inMDIWSSLNVPSGLGCVTVR----EEEGAALAASRIIGLTDPLVWCKLKTQQLEk 412
XP_011674663  346 TFPVINCPPVKadw----gaQDIWSSLRLPSGLGCTTTL----SPEGAAWQAAQIFGLTNHVVWGRVRARQLNt 411
XP_001622041  341 SFPVINCPPVSsgw----gaEDVWSSLRLPSGLGCTTAL----NPDGAAAAAAQILGLHDHIIWGSLRAKRLNM 406
XP_011434632  342 TWPVINCPPLSgdw----gsHDIWSSMRLPSGLGCATVM----FPEAAALCAAQILALNDHVIWGNVRAKQLNt 407
XP_002407164  272 AFPVINCPPLSgew----gpHDIWSSLRVPSGLGCTTVL----FPEAAALAAAQILGLSDHVIWAKLRASQLNt 337
XP_015783892  366 TVPVINCPPISdsa---tlsNDIWSSMRLPSGVGCTTIL----GADNAALAAAHIIANLSPFTWARIRSQQtyt 432
jgi:Mmah_0804 197 DVPVIGLPVSTgygigakgeAALYSMLQSCSVLSVVNIDAGfvAGAFAGRIANTVAAARE-QTNSTVTENQKsq 269
XP_027826817  344 AYPVISCPPLTpdw----gaQDVWSSLRLPSGLGCSTIL----SPEGSAQFAAQIFGLNNHLIWARLRASvlnt 409 sheep
XP_014346374  759 IYPVINCPPLTadw----gaQDIWSSLRMPSGLGCTTVL----SPEAAAQFAAQIFGLNNHVVWAKLRTNMLnt 824 coelacanth
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