2DMW,2NUP,3EGD,1IFQ,4B93,3KYQ,3BW6,1H8M,1IOU


Conserved Protein Domain Family
Longin
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cd14824: Longin 
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longin domain
Longin-domain is N-terminal domain of a subgroup of R-SNARE proteins, including VAMP7, Ykt6, and Sec22. Longin is one of the approximately 26 components required for transporting proteins from the ER to the plasma membrane, via the Golgi apparatus. It is necessary for the steps of the transfer from the ER to the Golgi complex. Longins are the only R-SNAREs that are common to all eukaryotes, and they are characterized by a conserved N-terminal domain with a profilin-like fold called a longin domain.
Links
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Statistics
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PSSM-Id: 341428
Aligned: 285 rows
Threshold Bit Score: 49.9469
Created: 3-Dec-2013
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
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Conserved site includes 6 residues -Click on image for an interactive view with Cn3D
Feature 1:lipid binding site [chemical binding site]
Evidence:
  • Structure:3KYQ; Rattus norvegicus longin domain of Ykt6 with bound lipid, contacts 4A
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Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
Feature 1     #                                       #  #                      #   # #       
2DMW_A     11 LFAVVArg------ttILAKHAwcg-------------gnFLEVTEQILAKips----ennKLTYSHG-NYLFHYICqd- 65  human
3KYQ_A      5 YSLSVFykge--pkavLLKAAYdvssfsff--qrssvqefMTFTSQLIVERsak-----gsRASVKEQ-EYLCHVYVrsd 74  Norway rat
Q3SEQ4      4 IAVLIAaynpvekkviILTRYYelnsvgif--yrntvkdsMKFVCRESVIGldk-----gtRHSVMHE-DKYCHIQMgyg 75  Paramecium tetraur...
BAM79839   17 LYCAICrwe----drvVLARYAapragvalaetgastaafAETLRRILQSKkia----ehkRLTIEEKqLGMIHYDNdg- 87  Cyanidioschyzon me...
CDF38102    5 VYMGIArvp----dkqILVSCVatdsre------qskqqlDSILSRVLVSGrid----ehdRLTIADKdVGNIHYSAdp- 69  carragheen
CCA17529   44 KFIGVArat----dkaIICCYFhsakastnv-dlaecakwKEMYAKVLRAPtwktqvtpnaRHSLDCD-PNKFHFSMsnd 117 Albugo laibachii Nc14
CBN77436    6 TFLGVIrft----drvLVAGYSpse-------------adDSLIIKELMSNpdtfv-eprkRYSVEGR-MFSIHFVAdds 66  Ectocarpus silicul...
CDF32135    8 RYVAVArlt----drvPVAEYAaidsre------vptkllDEKLEKVLRSGrve----ehtRLTITDReVGSIHYDSdp- 72  carragheen
EQC38653    9 KFLAVArgs----dkaIIASYAhtkkdk------eespkyLDMLTKVLRAPtwkqqvapnsRHTLDCE-PNKFHFTMdnd 77  Saprolegnia diclin...
EEY58324   17 KFLAIArat----dkvIVASYMhpsggkparggeaematfREMLSKVIRAPtwktqvtpngRHSLECD-PNKFHFTMnnd 91  Phytophthora infes...

Feature 1                                                                     
2DMW_A     66 --riVYLCITDdDFERSRAFNFLNEIKKRFQTTYgsraqtap---pyamnseFSSVLAAQLKHH 124 human
3KYQ_A     75 --slAGVVIADsEYPSRVAFTLLEKVLDEFSKQVdridwpv-----gspatiHYTALDGHLSRY 131 Norway rat
Q3SEQ4     76 sdkvGAYAFCDqDYPKRIAFAFLNAVLQAFQKKVgddwkky-----kedesiEVPEIKQLFQEY 134 Paramecium tetraurelia
BAM79839   88 --tcMYVVFCRaSYPQRLAFQFLNELRSEFLRTVgsrpedvasatensltklCRPLMSELCTLY 149 Cyanidioschyzon merolae strain 10D
CDF38102   70 --alVYLVITAtNYPQRTAFKLLSEARAEFEQEFktelaggk---ndgvakvAKPFLKRMMDRY 128 carragheen
CCA17529  118 --elVFAVITVkSYPIRLAFQLIQTLQQEFVPKFatkalncr---ehgldkeCKSMMQTLANQY 176 Albugo laibachii Nc14
CBN77436   67 --nrIYSCVTDkEYPARIAFTLLEEAQTKFLTKVgdksltak---egglsrtMKSSFSDLCIKY 125 Ectocarpus siliculosus
CDF32135   73 --vcLYLVVCArEYQQRNAFKFLGEVRREFDASFgndvqtar---qsglsrpAKELLRSLCEKY 131 carragheen
EQC38653   78 --eiVYVAITAaDYPVRLAFKLLAAVQEEMTGKHaaklptvk---eggldkeCAKGLSVIATTY 136 Saprolegnia diclina VS20
EEY58324   92 --elVFAAITAkDYPIRLAFQMISAVQTDVVPKFgskaltcr---engldkdCAKALAGIATGY 150 Phytophthora infestans T30-4

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