6M6F,6M6E


Conserved Protein Domain Family
beta-trefoil_FGF21
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cd23332: beta-trefoil_FGF21 
FGF domain, beta-trefoil fold, found in fibroblast growth factor 21 (FGF21) and similar proteins
FGF21 stimulates glucose uptake in differentiated adipocytes via the induction of glucose transporter SLC2A1/GLUT1 expression (but not SLC2A4/GLUT4 expression). Its activity requires the presence of beta-Klotho (KLB). It interacts (via C-terminus) with KLB and fibroblast growth factor receptor FGFR4. FGF21 contains a FGF domain with beta-trefoil fold, which is characterized by 12 beta strands folded into three similar trefoil subdomains (alpha, beta, and gamma) associated to give an overall structure with pseudo-3-fold symmetry.
Links
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Statistics
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PSSM-Id: 467018
Aligned: 7 rows
Threshold Bit Score: 211.571
Created: 6-Apr-2021
Updated: 27-Apr-2023
Structure
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Program:
Drawing:
Aligned Rows:
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PubMed ReferencesClick to see Conserved Features Help
Sequence Alignment
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Format: Row Display: Color Bits: Type Selection: 
6M6F_A         2 QVRQRYLYTSGphglSSCHLEIReDGTVGCAAdQSPESLLQLKALKPGVIQILGVKTSRFLCQRpDGALYGSLHFdpEAC 81  human
6M6E_A         2 QVRQRYLYTDDaq-qTEAHLEIReDGTVGGAAdQSPESLLQLKALKPGVIQILGVKTSRFLCQRpDGALYGSLHFdpEAC 80  human
Q9NSA1        43 QVRQRYLYTDDaq-qTEAHLEIReDGTVGGAAdQSPESLLQLKALKPGVIQILGVKTSRFLCQRpDGALYGSLHFdpEAC 121 human
XP_014352523  79 SIRLRHLYTASe--sRHLHLQINsDGQVGGTTkQSPYSLLEMKAVKTGFVVIRGKKSARYLCMErSGRLYGSLQYteKDC 156 coelacanth
XP_014383459  46 QVRLRHLYTANe--hTQLHLEILpDGRVRGVPqQSPYSLMEIKAVKPGVVQIQAAKSLQFLCMDvRGRLYGAGSYstEAC 123 Chinese alligator
XP_029440306  49 LVRLRHLYTEDe--qIHLHLQITeDGDVTGTReQNIYSLLEIKAVKPSILVIRGKKSLRYLCMDaTGRLFGSKVYsvTDC 126 two-lined caeci...
XP_030053699  49 LVRLRHLYTADe--nIQLHLQITeNGEVTGAKeQNIYSLLEMKAVKPSVLVIQGKKTLRYLCMDsMGRLFGSEVYseTDC 126 Microcaecilia u...

6M6F_A        82 SFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRdp--apRGPARFLPLP 128 human
6M6E_A        81 SFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRdp--apRGPARFLPLP 127 human
Q9NSA1       122 SFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRdp--apRGPARFLPLP 168 human
XP_014352523 157 TFKEVVLADGYNLYVSEEHQATVTLSPMRARIAqgk-kiPPFSHFLPMV 204 coelacanth
XP_014383459 124 NFREKVLSDGYNLYISEHHNRPLSLTPSGALPGtgr-psPPLIQWLPLA 171 Chinese alligator
XP_029440306 127 HFREVPLQDGYNLYFSEKHHAPLTLSSARTRAPwsgralPPLSHFLPLV 175 two-lined caecilian
XP_030053699 127 HFREVPLSDGYNLYFSEKHRMPLTLSDVRTGGIgtgralPPLCHFLPLV 175 Microcaecilia unicolor
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