3FUB,3FUB


Conserved Protein Domain Family
GDNF

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smart00907: GDNF 
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GDNF/GAS1 domain
This cysteine rich domain is found in multiple copies in GNDF and GAS1 proteins. GDNF and neurturin (NTN) receptors are potent survival factors for sympathetic, sensory and central nervous system neurons.. GDNF and neurturin promote neuronal survival by signaling through similar multicomponent receptors that consist of a common receptor tyrosine kinase and a member of a GPI-linked family of receptors that determines ligand specificity.
Statistics
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PSSM-Id: 197975
Aligned: 97 rows
Threshold Bit Score: 31.843
Created: 12-Jul-2011
Updated: 2-Oct-2020
Structure
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Program:
Drawing:
Aligned Rows:
PubMed ReferencesClick to see Conserved Features Help

Sequence Alignment
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Format: Row Display: Color Bits: Type Selection:
3FUB_A         99 CLSLQDSCKTNYICRSRLADFFTNCQPESRSVsnCLK-ENYADCLLAYsglI--------GTVMTPNYV--D--SSslS- 164  Norway rat
XP_001157000  220 CLSVIRSCQNDELCRRHYRTFQSKCWQRVtRK--CHE-D--ENCISAL---SkqdltcsgSDDCKAAYI--DilGT--V- 286  chimpanzee
NP_995316     220 CLSVIHTCRNDELCRTHYRTFQTECWPHITGK--CHEdE---TCISML---GkqdltcsgSESCRAAFL--G--TF--Gt 285  house mouse
XP_001505459  293 CLNVIRSCRDDELCRQRFETFQSKCWQd-mDK--CSDdE---TCIVTL---NkenitcsrNEECREAYI--G--TL--Gt 357  platypus
XP_001371512  222 CLDVIRNCRVDEICRSRYETFQAKCWQRVTEK--CYYdE---TCINTF---SkedltcsaDDKCKAAYIdtV--GT--I- 288  gray short-ta...
XP_419904     361 CLSVIHMCEENELCRKIFKTFWDKCWRHVTKE--CYDdE---ACLETL---IkddmpcsaNADCKAAYIsnW--GT--M- 427  chicken
XP_002934908  141 CVDVIHRCLKDELCRQGYETYLSKCWCg-----------NNENCLRYT---SieelscsgDDNCKAAYI--S--TL--Gt 200  western clawe...
NP_500240      57 CLHYRSICLRNDTCNQHLKRFQTTCGYd-lNV--CSGt-SPSDCVYYL---Hr-------IREIFPTKS----------- 111  nematode
NP_001014642  284 CHTALDTCREDPSCSSSLQPMLTHCEL--------------HRCNRNA---C--------MSSLQAFYKgpH--ED--Ln 334  fruit fly
NP_500240     495 CPDAIRRCESVDECRWHLGELRVRCASTAS-------------CQREE---C--------AQSLQRFVTyvP--FA--Li 546  nematode
3FUB_A        165 -VAPWCDCsnS--G--NDLED--CLKFLNFFKDNTC 193  Norway rat
XP_001157000  287 -LQVQCTC--Rt-I--TQSEEslCKIFQHMLHRKSC 316  chimpanzee
NP_995316     286 vLQVPCAC--Rg-VtqAEEHV--CMIFQHMLHSKSC 316  house mouse
XP_001505459  358 yLHVQCTC--St-LslTEEYL--CKIFHHILHSRSC 388  platypus
XP_001371512  289 -LHAQCTC--Gs-IpfTERPL--CEIFSHMLQSTSC 318  gray short-tailed opossum
XP_419904     428 -LHVECTC--Qn-SppAEQSL--CKLFHHMLHSTSC 457  chicken
XP_002934908  201 dLHMQCTC--SpaLgvEDQRL--CRIFYHMIHSKSC 232  western clawed frog
NP_500240     112 -----CTC--YeaIg--FSQE--CDFFRQIIWNHSC 136  nematode
NP_001014642  335 lDIAFCLC--K-------KTS--SQQNGNGNRHDMC 359  fruit fly
NP_500240     547 eSIMFCHC--A-----PEDEG--CLTQQNQFLAHIL 573  nematode
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